794 search results for “immunity infection and tolerance” in the Public website
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Staying Ahead of the Virus
In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Immune system plays dual role in breast cancer
The immune system plays a paradoxical role in the spread of breast cancer. Some immune cells contribute to metastasis, while other cells can be activated to strengthen the effect of chemotherapy. Kelly Kersten made this discovery in her PhD research. PhD defence 7 February.
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Translational Immuno-Pharmacology
The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…
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Development of cross-protective influenza A vaccines based on cellular responses
Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…
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Pleading for Diversity: The Church Caspar Coolhaes Wanted
Linda Stuckrath Gottschalk defended her thesis on 6 April 2016.
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.
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ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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In war crimes, commanders do not have legal immunity
In her capacity as a lawyer and expert in International Humanitarian Law and Human Rights, Professor Helen Duffy is filing a lawsuit against the Dutch State. Leiden University’s weekly newspaper Mare reports that through her role, Duffy is assisting a Palestinian Dutchman whose family was killed in…
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Better vaccines against malaria and tuberculosis
The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.
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Plant-microbe interactions
Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?
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Cytokine-mediated regulation of immunity during persistent viral infection
PhD defence
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Monitoring the immune responses to vaccination and infection
PhD defence
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Inflammafish: Cross-talk between inflammation and autophagy in tuberculosis
Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars
The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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A chemical connection that affects your immune system
A group of chemists, that includes Sander van Kasteren and Hermen Overkleeft, has discovered that azides, a certain type of chemical compound, can determine whether or not T cells respond to or ignore a vaccine. Their discovery is set to be published in Angewandte Chemie.
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Antiviral strategies against emerging coronaviruses
PhD defence
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Key publications
Key publications of the Biologics Formulation group
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mRNA boosters are the most effective upon receiving Janssen vaccination
A coronavirus booster shot provides a better immune response against COVID-19 than a single vaccine dose. mRNA boosters are the most effective upon receiving Janssen. These are the results of a collaborative study between several organisations, including the Leiden University Medical Center (LUMC).…
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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A vaccine against thickened artery walls
Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
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Grant: Dr. Amanda Foks receives a prestigious Junior Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Influenza T-cell epitope-loaded virosomes adjuvanted with CpG as a potential influenza vaccine
Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…
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Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…
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Bram Slütter
Science
b.a.slutter@lacdr.leidenuniv.nl | +31 71 527 6208
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Improving PTSD treatment for adults with childhood trauma (IMPACT-study)
The aim of this project is to investigate the (cost)effectiveness of two innovative forms of trauma-focused therapy for patients with childhood abuse related PTSD. The ultimate goal is to improve quality of care and contribute to treatment innovation for this severely ill target population.
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Invasive plant species, models for evolutionary change
Which traits did change due to the invasion process of plants and how do these traits contribute to the invasiveness of such species. What is the role of carbohydrate accumulation? What is the function of carbohydrate accumulation in plants? Is genetic variation depleted in invasive species under se…
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Why COVID-19 caused a pandemic (whereas other coronaviruses did not)
Epithelial cells play a crucial role in the lungs. PhD student Ying Wang researched the effects of cigarette smoke and viruses such as COVID-19 on these epithelial cells. ‘We hope to reduce the risk of pandemics in the future.’
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Ovalbumin coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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Noortje Dannenberg
Science
n.dannenberg@biology.leidenuniv.nl | +31 71 527 5075
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.