On 29 April 2016 Rick Honings' book 'De dichter als idool. Literaire roem in de negentiende eeuw' (The poet as pop star) was presented.

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The Wadi al Jizzi Archaeological Project is a systematic and long term archaeological surface survey project, investigating the rich archaeological heritage of the Wadi al Jizzi region (Oman) from the Paleolithic until the early Modern period.

The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…

Estudio arqueológico de la primera ciudad española en la Tierra Firme de América: Santa María de la Antigua del Darién

About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.

Zijn sociale aspecten van anxiety-like gedrag bij zeer jonge zebravissen al aanwezig? Zijn deze afhankelijk van de coping style (persoonlijkheid) van het individu? Zijn deze gedragingen endocrien te moduleren, bv door oxytocine?

Nadine Raaphorst wrote an chapter for The Oxford Handbook of Administrative Justice about how two notions of fairness are studied in street-level bureaucracy literature and about the factors that influence how bureaucrats behave in this regard.

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

The aim of this project is to investigate the (cost)effectiveness of two innovative forms of trauma-focused therapy for patients with childhood abuse related PTSD. The ultimate goal is to improve quality of care and contribute to treatment innovation for this severely ill target population.

In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.

This volume sheds light on the role played by progeny in maintaining dynasties in early modern royal courts as well as the horizontal and vertical interplay between the actors. It attempts to break through the narrative of older research that saw dynasties as a series of male rulers. Instead, these…

Can a newly developed, app-based, personalized maintenance program enhance the effectiveness of the exposure-based one-session-treatment for children with a specific phobia?

Governments in parliamentary democracies have limited time in office to fulfill their policy agendas. So, how do they optimise the timing of legislative bills to assure their passage and avoid lengthy parliamentary scrutiny? This question is especially puzzling under coalition governments, in which…

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Imagine how much time, money and discomfort it would save: a personalised treatment for each individual patient. Precision medicine like this is coming ever closer, thanks in part to Elise Dusseldorp’s algorithms. They retrieve a wealth of information from research data.

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

If a new method has been developed to recognize and treat a (neuro-)psychological disorder or related behavioral factors, it cannot yet be used directly in clinical practice. First, the method should be evaluated, preferably in randomized controlled trials.

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Monique Koemans werkt sinds 2,5 jaar op de Nederlandse ambassade in de Verenigde Staten. 'Leiden is een opvallende rode draad in mijn leven.'

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

PhD defence

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This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…