2,331 search results for “mexican drug violence” in the Public website
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Rebels and Conflict Escalation: Explaining the Rise and Decline in Violence
Violence during war often involves upswings and downturns that have, to date, been insufficiently explained. Why does violence at a particular point in time increase in intensity and why do actors in war decrease the level of violence at other points? Duyvesteyn discusses the potential explanatory variables…
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Of ticking bombs: Western security services against political violence and terrorism
How have British, Dutch, and German security services dealt with political violence and terrorism since the late 1960s; to what extent did they consider these new phenomena as a task and how have they developed activities in order to counter these security threats?
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Beyond the Pale: Dutch Extreme Violence in the Indonesian War of Independence, 1945-1949
On 17 August 1945, two days after the Japanese surrender that also brought an end to the Second World War in Asia, Indonesia declared its independence. The declaration was not recognized by the Netherlands, which resorted to force in its attempt to take control of the inevitable process of decolonization.…
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Archaeologist Omar Aguilar Sánchez receives Mexican youth prize
On October 21st, 2019, the President of Mexico, Andrés Manuel López Obrador, handed out the National Prize for the Youth in the academic achievement category to our PhD candidate Omar Aguilar Sánchez. He received this honour for his work on Mixtec pictorial manuscripts.
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Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
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Transnational Pentecostalism in the Age of #MeToo: Sexual Violence and Harassment from Lagos to Los Angeles
This initiative is intended to support generative research collaborations between and among scholars located in different geographical regions who wish to pursue focused, joint projects in any area of the study of religion.
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What sets extremists who use terrorist violence apart from those who do not?
This paper contributes on an increasing body of work on radicalisation. It specifically focuses on what distinguishes individuals whose behavioural radicalisation includes involvement in terrorist violence from those whose behavioural radicalisation does not.
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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The Dutch and English East India Companies: Diplomacy, Trade and Violence in Early Modern Asia
The Dutch and English East India Companies were formidable organizations that were gifted with expansive powers that allowed them to conduct diplomacy, wage war and seize territorial possessions. But they did not move into an empty arena in which they were free to deploy these powers without resista…
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Freedom and the Fifth Commandment. Catholic priests and political violence in Ireland, 1919-21
A new paperback edition of Brian Heffernan's book Freedom and the Fifth Commandment. Catholic priests and political violence in Ireland, 1919-21 was published by Manchester University Press in September 2016.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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New track 'Governance of Violence' addresses need to conduct violence specific studies
The sixth specialisation of the Master Crisis and Security Management (CSM) will start in September 2023: Governance of Violence. Coordinator of this track is Professor Marieke Liem. She talks about the how and why of this new track and the importance of research in and knowledge of the nature and scope…
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Maarten Jansen compares ancient Mexican writing systems as Distinguished Emeritus Professor in Bonn
Maarten Jansen, professor emeritus at the Faculty of Archaeology, was appointed as Distinguished Emeritus Professor for two years at the University of Bonn. In this position, Jansen, a world-renowned specialist on ancient Mexican pictorial manuscripts, will further expand upon the long-standing collaboration…
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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namic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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generation human IPSC-derived reporter systems for image-based analysis of drug adversity
Analysis of drug adversity
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Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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A community effort to assess and improve drug sensitivity prediction algorithms
Source: Nature Biotechnology, Volume 2014, Issue June (2014)
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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Hildert Bronkhorst
Science
h.bronkhorst@biology.leidenuniv.nl | +31 71 527 4964
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Still no equal rights for native Mexican women
Native women are invisible in Mexican society. This is the conclusion Barbara Ortiz draws in her dissertation. PhD defence on 23 February.
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throughput microscopy for cellular adaptive stress response pathways in drug adversity
High throughput microscopy
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Gerard van Westen: 'Our model predicts what candidate drugs do in your body'
He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…
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Jeanette Satink
Faculteit Rechtsgeleerdheid
a.e.j.satink@law.leidenuniv.nl | +31 71 527 2727
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst
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conflict minerals: The complex links between artisanal gold mining and violence
Policy Note Insecurity in Burkina Faso – beyond conflict minerals: The complex links between artisanal gold mining and violence
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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‘The favourite candidate in the Mexican presidential election is another Trump.'
Mexico will be electing a new president on 1 July. No matter who wins, there will be little change in the deep political crisis affecting the country. This is the message given by José Carlos G. Aguiar, university lecturer in Latin American studies.
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3 October University: from Russian DNA to drug-related violence
In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Leiden Law School and the Mexican Supreme Court strengthen collaboration
Leiden Law School and the Center for Constitutional Studies of the Mexican Supreme Court (CEC-SCJN) have signed a memorandum of understanding, to carry out joint activities in the field of constitutional law and children's rights.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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characteristics and immediate situational factors in the outcome of serious violence
Why do certain incidents of serious violence end lethally whereas others do not? What role do personal characteristics of offenders and victims play and how do immediate situational factors influence outcomes?
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system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Polypept(o)ide-based Cylindrical Polymer Brushes as Multifunctional Drug Delivery Systems
The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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Group violence: collective and individual issue
The out of control ‘Project X’ event in Haren, hooligans who arrange to meet up to fight and beach riots at the Hoek van Holland: group violence is increasingly hitting the headlines. Are those who took part seasoned criminals? And what characteristics do group offenders have? PhD defence on 29 September…
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Blog Post | The storming of the Mexican Embassy in Ecuador: Inviolability and Political Asylum
On Friday, April 5, the Ecuadorian police stormed the Mexican Embassy in Quito to arrest former Ecuadorian vice president Jorge Glas Espinel.
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Graig Klein
Faculty Governance and Global Affairs
g.r.e.klein@fgga.leidenuniv.nl | +31 70 800 9506
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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New courses on 'Violence'
In the academic year 2021-2022 the Social Resilience and Security interdisciplinary programme will offer two courses for interested students who are entering the third year of their Bachelor's degree. You can sign up for these courses in your elective (minor) space. The courses are available to students…
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?