796 search results for “antibiotic resistance” in the Public website
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
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Soil bacteria can produce a wealth of new antibiotics
Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.
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Sugarcoating the search for a new vaccine
A vaccine based on sugar coats does have the potential to combat a multi-resistant staphylococcus. That is what Jeroen Codée and his colleagues from Utrecht state in Nature. In doing so, they are contradicting the earlier conclusions of German colleagues.
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Key publications
Key publications of the Quantitative Pharmacology group
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Evolution & Biodiversity in Microbial Sciences
Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.
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New insights into the production of antibiotics by bacteria
Bacteria use antibiotics as a weapon and even produce more antibiotics if there are competing strains nearby. This is a fundamental insight that can help find new antibiotics. Leiden scientists Daniel Rozen and Gilles van Wezel published their research results in the authoritative Proceedings of the…
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Bioactive Molecules in Microbial Sciences
Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Ghosts Here and There: Spectral Resistance and Dialogue in Postcolonial Literature
The ethics of ghosts, spectres, and mediums in postcolonial literature
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Business Against Markets: Employer Resistance to Collective Bargaining Liberalization During the Eurozone Crisis
Employer organizations have been presented as strong promoters of the liberalization of industrial relations in Europe. This article, in contrast, argues that the preferences of employers vis-à-vis liberalization are heterogeneous and documents how employer organizations in Spain, Italy, and Portugal…
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Gilles van Wezel
Science
g.wezel@biology.leidenuniv.nl | +31 71 527 4310
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Lizah van der Aart makes glossy about PhD research
After four years of hard work, the time has finally come: your thesis is finished. But who of your family and friends will ever read it? Biologist Lizah van der Aart decided to make a magazine for layman. 'It was precisely the explanation of the difficult, fundamental parts that gave me good tools for…
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Slave in a Palanquin: Colonial Servitude and Resistance in Sri Lanka
For hundreds of years, the island of Sri Lanka was a crucial stopover for people and goods in the Indian Ocean. For the Dutch East India Company, it was also a crossroads in the Indian Ocean slave trade. Slavery was present in multiple forms in Sri Lanka—then Ceylon—when the British conquered the island…
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Resistance against the Achaemenid Empire: The Egyptian Rebellions of 521 and 487/86 BC
On 15 February 2023 Uzume Wijnsma successfully defended a doctoral thesis and graduated.
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in primary care: a multi – dimensional approach to antimicrobial resistance
PhD defence
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The role of animals in the epidemiology of antimicrobial resistance in humans
PhD defence
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Scientists discover how to improve the production of antibiotics and enzymes in soil bacteria
A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.
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On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies
On 7 September, Francesc Claret Traid defended the thesis 'On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies'. The doctoral research was supervised by Afshin Ellian and Gelijn Molier.
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Languages of Resistance, Transformation, and Futurity in Mediterranean Crisis-Scapes
From Crisis to Critique
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Artistic Research in Music: Discipline and Resistance - Artists and Researchers at the Orpheus Institute
Artistic research has come of age, and with it the Orpheus Institute. Founded twenty years ago, the Institute’s purpose from the start has been to pursue research through the practice of musicians.
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Resistance and Revolt in Egypt and Babylonia: The Persian Empire (539-330 BC) in the Eyes of its Rebels
The Persian Empire (539-330 BCE) was the first world empire in history. At its height, it united a territory stretching from present-day India to Libya - and it would take 2,000 years before significantly larger empires emerged in early modern Eurasia. Its size and power was revered by some, feared…
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Microbial protection of food crops and human health
We investigate bacteria and fungi to understand their malicious or beneficial impact on food crops and their pathogenic or antibiotic role in human health.
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Projects
An overview of Quantitative Pharmacology projects
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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PhD Theses
A full overview of MacBio PhD Theses.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Science for Society
By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.
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From stress to success: how actinobacteria exploit life without a cell wall
The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.
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Marcellus Ubbink receives grant for research into evolution of enzymes
The Dutch organisation for scientific research NWO has announced that it will award an ENW-Klein grant to Marcellus Ubbink (LIC) for his research into the role of temperature in the evolution of enzymes. Sixteen grants have been awarded in total.
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Research
Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…
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Improving the treatment of newborn babies with life-threatening sepsis
Coen van Hasselt’s pharmacology group collaborated on a study recently published in the renowned Lancet Infectious Diseases. The international team mapped the antibiotic treatment of the life-threatening inflammatory reaction sepsis in newborn babies. They did this for low- and middle-income countries,…
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Negotiating Islamisation and resistance : a study of religions, politics and social change in West Java from the early 20th Century to the present
Chaider Bamualim defended his thesis on 9 September 2015
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Institute of Biology Leiden
The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.
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Wetenschappers ontdekken hoe darmbacterie resistent wordt
Een minuscuul cirkelvormig stukje DNA zorgt ervoor dat de darmbacterie Clostridioides difficile resistent raakt tegen een veelgebruikt antibioticum. Dat ontdekten wetenschappers van het Leids Universitair Medisch Centrum (LUMC) nadat artsen hen attendeerden op een patiënt met een moeilijk behandelbare…
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Michael Richardson in TV show Willem Wever about antibiotics from snake venom
'What do people do with snake venom?' That's the question 11-year-old Joep asked in Dutch TV show Willem Wever. Leiden Professor of Evolutionary developmental zoology and snake venom expert Michael Richardson answers the question in his laboratory.
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Frederic Lens
Science
f.p.lens@biology.leidenuniv.nl | +31 71 527 2727
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New techniques for tuberculosis treatment
About nine million people worldwide contract tuberculosis each year. Research into new treatment for this disease has received fresh stimulus with more efficient techniques and a new understanding of how the tuberculosis bacteria works.
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Greenifying industrial biotechnology through the creation of synthetic endosymbionts
Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?
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Focus Honours Community on internationals and The Hague
The study association of honours education SLHC established an international commission concerned with the closer involvement of international students in the Honours Community. The language of communication will become English where possible, and more upcoming activities will be organised in The Hague…
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Remembering Leiden-Indonesian resistance fighter Irawan Soejono
Large numbers of Indonesians were active members of the resistance during the Second World War. One of them was Irawan Soejono, a student at Leiden University. He was shot dead on Boommarkt, during a raid on 13 January 1945. Seventy-five years later he was remembered in a small ceremony in the very…
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…