154 search results for “protein” in the Staff website
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Long-Term Observation of Protein Dynamics via Thermal-Snapshot Single Molecule Spectroscopy
PhD defence
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Versatile antiviral proteins discovered with supercomputer
A single tiny molecule that can destroy flu, corona, HIV and Zika viruses? Yes, it really does exist. Biophysicist Niek van Hilten, who will receive his doctorate on 14 September, contributed to this discovery.
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A high protein diet may accelerate atherosclerosis
A widely publicized research article in Nature Metabolism by scientist from the University of Pittsburgh, suggests a high protein diet which is popular among for instance fitness enthusiasts, may be harmful to the cardiovascular system. National media outlets such as NRC Handelsdagblad and NPO 1 Radio…
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Biological Origami at molecular level: folding a single protein
Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…
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Kroonvoordracht 2023: Protein Tales of the Human Past
Research
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Lars Jeuken
Science
l.j.c.jeuken@lic.leidenuniv.nl | +31 71 527 4755
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How cells determine the fate of proteins (and can we do it too?)
Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…
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Paul Hooykaas
Science
p.j.j.hooykaas@biology.leidenuniv.nl | +31 71 527 4933
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Can Parkinson's be stopped by unravelling protein fibres? Anne Wentink finds out with a Vidi grant from NWO
In brain diseases such as Parkinson's and Alzheimer's, proteins clump together to form fibres. ‘Chaperone proteins’ unravel those fibres, but in the test tube biochemist Anne Wentink saw that this can also cause new problems. She is going to find out what happens inside cells to determine what a drug…
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Aimee Boyle
Science
a.l.boyle@lic.leidenuniv.nl | +31 71 527 2727
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Marcellus Ubbink
Science
m.ubbink@chem.leidenuniv.nl | +31 71 527 4628
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Priyanka Chopra
Science
p.chopra@biology.leidenuniv.nl | +31 71 527 1886
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Adriaan IJzerman
Science
ijzerman@lacdr.leidenuniv.nl | +31 71 527 2727
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Elmer Maurits
Science
e.maurits@lic.leidenuniv.nl | +31 71 527 2727
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Hermen Overkleeft
Science
h.s.overkleeft@chem.leidenuniv.nl | +31 71 527 5037
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Joachim van Guyse
Science
j.f.r.van.guyse@lacdr.leidenuniv.nl | +31 71 527 4314
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Anjali Pandit
Science
a.pandit@chem.leidenuniv.nl | +31 71 527 4198
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Berend Gagestein
Science
b.gagestein@lic.leidenuniv.nl | +31 71 527 2727
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Peptide-Based Probes for Protein N-Methyltransferases
PhD defence
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Leiden chemists discover new ways in which single-celled organisms organise their DNA
It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…
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Arthur Ram
Science
a.f.j.ram@biology.leidenuniv.nl | +31 71 527 4914
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Natalia Ortiz Zacarias
Science
n.v.ortiz.zacarias@lacdr.leidenuniv.nl | +31 71 527 2727
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Salma Balazadeh
Science
s.balazadeh@biology.leidenuniv.nl | +31 71 527 4790
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
PhD defence
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Artificial metallo-proteins for photocatalytic water splitting: Stability and activity in artificial photosynthesis
PhD defence
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
PhD defence
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Cancer-induced somatic mutations in G protein-coupled receptors
PhD defence
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Dynamics of Single Protein Molecules by Temperature Cycling under Laser Heating
PhD defence
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Not wrapping but folding: Bacteria also organise their DNA (but they do it a bit differently)
Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…
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The Pursuit of Competence: Why our students need more meaningful challenges, not less.
The Leiden Academic Centre for Drug Research (LACDR) is closely connected to the education of our biopharmaceutical students, providing both courses and immersive internship projects. Among these is the Bachelor Research Project (BOO), which offers many students their first real scientific experience…
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space smarter: Artificial intelligence in drug design for G protein-coupled receptors
PhD defence
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Chao Du
Science
c.du@biology.leidenuniv.nl | +31 71 527 4947
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Animal-friendly and effective: Leiden students develop nanobodies using yeast
Yeast, alpacas, and antibodies. They may seem unrelated, but within the project of the Leiden iGEM students, they come together perfectly. For the international synthetic biology competition iGEM, the team is working on an innovative method to produce nanobodies—a special form of antibodies—using brewer’s…
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Studying ferritin: ‘we hope this will eventually give more insight into Alzheimer's’
Martina Huber, Jacqueline Labra Munoz research Alzheimer's disease. They study ferritine, iron storage in the brain. An inbalance of iron could play a role in this form of dementia.
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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Targeting the immune system to inhibit atherosclerosis
A new treatment for atherosclerosis showed promising results in isolated cells but proved to be less effective in initial animal tests. Bachelor student Biopharmaceutical Sciences Willemijn van der Heijden aimed to understand why. She investigated whether the formation of a protein layer around the…
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Leiden researchers visualise the 'guardian of our genome’
The guardian of our genome, the protein MutS, scans the DNA for spelling errors and makes sure they are corrected. An essential process for our health. Researchers at Leiden University Medical Centre (LUMC) have discovered precisely how this protein works by making MutS visible with cryo-electron microscopy.…
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700,000 euros for the fight against aggressive breast cancer
To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…
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How to hijack natural destruction in cells: ‘We need to understand it through and through’
Destroying proteins from the Golgi apparatus of the cell in a controlled manner. That is the focus of chemist Marta Artola’s pioneering research. By developing a groundbreaking technology to target specific proteins in the Golgi, Artola aims to unlock new ways for drug development. For this ambitious…
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Antibiotics of the future: looking for a new way to kill bacteria
Current antibiotics only address very few target proteins in bacteria to kill them. Researchers know that there are more possible target proteins to tackle the bacteria. The question is: which ones. Thanks to the NWO Vidi Grant, Assistant Professor Molecular Physiology Stephan Hacker and his team can…
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How NeCEN helped develop the Johnson & Johnson Covid-19 vaccine
The Phase 3 clinical trial results of the promising Covid-19 vaccine of Johnson & Johnson are expected this month. The Dutch electron microscopy facility NeCEN helped develop the company’s vaccine, and they have now published their scientific findings in Nature Communications.
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The career choices of cells
How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.
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Caught in living cells: how bacteria regulate their genes to defend themselves
For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…
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‘Look beyond your own discipline’
Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.
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Recent PhD defenses
Here we highlight the achievements of our latest PhD graduates, each of whom has made significant contributions to the advancement of the field of (bio)pharmaceutical sciences.
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How fungi are helping us be more sustainable
Professor of Fungal Genetics and Biotechnology Arthur Ram explains how fungi can help us be more sustainable.
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How bittersweet sugar chemistry targets pathogens
The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.
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Successful symposium on Circuit Topology
On the 8th of December 2021, Leiden Academic Centre for Drug Research (LACDR) organized “Circuit Topology 2021”, the first international symposium on circuit topology. The focus was on the mathematical notion of Circuit Topology, and its applications to physics, chemistry and biomedicine.
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Circuit Topology 2022
For the second year in a row, LACDR organized an international symposium on molecular fold topology. An afternoon program centered around the theme “circuit topology”, inspired and connected mathematicians, physicists and chemists. Scientists from USA, Europe, and Asia participated in this online ev…