835 search results for “antibiotic resistance” in the Public website
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Institute of Biology
Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Inaugural lecture Annemarie Meijer
On Monday 21 September Annemarie Meijer, Professor of Immunobiology, presented her inaugural lecture on immunobiology and infectious disease.
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
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New funding for the development of a metabolomics resistance test at the IBL
Researchers from the Plant Ecology and Phytochemistry group at the Institute of Biology Leiden (IBL) received an STW (Stichting Technologische Wetenschappen) grant for applied studies in plant herbivore resistance with potential for a novel resistance test.
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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What did resistance look like in Indonesia during the Second World War?
Stories of resistance in the Second World War are widely covered in Dutch historiography: Hannie Schaft, Erik Hazelhoff Roelfzema, and Professor Cleveringa are some of the best known. But these accounts largely focus on the Dutch domestic perspective. On the other side of the world, a complex colonial…
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Indonesian resistance hero and Leiden student Irawan Soejono is given a face
To mark its 75th anniversary, the Netherlands War Graves Foundation is publishing a portrait of a war victim every week this year. On 24 January the drawing of Irawan Soejono, a Leiden student and Indonesian resistance member, was unveiled at the Groenesteeg cemetery in Leiden, the place where Soejono…
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Jiahui Wang
Science
j.h.wang@cml.leidenuniv.nl | +31 71 527 2727
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Coen van Hasselt
Science
coen.vanhasselt@lacdr.leidenuniv.nl | +31 71 527 3266
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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Macrophages as drivers of an opportunistic infection
The opportunistic bacterium Burkholderia cenocepacia is feared by cystic fibrosis patients and is emerging in hospital-acquired infections. An international study sheds new light on the infection mechanism of this opportunistic pathogen that may have large implications for treatment strategies.
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Annemarie Meijer appointed full Professor of Immunobiology
Annemarie Meijer is appointed full Professor of Immunobiology. Meijer’s research focuses on immunobiology and infectious disease. She uses the zebrafish as a model for understanding mechanisms of host immune defense against intracellular bacterial pathogens.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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IBL-research interview: Daniel Rozen
Daniel Rozen (45), at the IBL since September 2012, uses bacteria in laboratory tests on experimental evolution to study the ecology and genetics of adaptation. His research has applied importance, as it reveals how bacteria may be induced to produce new antibiotics. Last January, Rozen received the…
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Publication: Artistic Research in Music: Discipline and Resistance - Artists and Researchers at the Orpheus Institute
Book publication 'Artistic Research in Music: Discipline and Resistance' marks the 20th anniversary of the Orpheus Institute..
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Regulatory networks in Streptomyces
We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
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“You cannot predict the future, but you can think about it!” Master’s Vitality and Ageing visits Vilans!
As part of the career orientation of the Master’s Vitality and Ageing, students visit various healthcare, policy and research organisations throughout the year. Students get introduced to relevant organisations where they have the possibility for a graduation internship and career opportunities. This…
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Awards and Grants 2022
An overview of awards and prizes granted to our staff and students in 2022, as well as special appointments at Leiden University and other institutions.
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
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Vertical interventions? The local politics of migration management and policing in intra-Schengen borderlands
What is the role of local authorities and communities in shaping how inter-Schengen borders are understood and dealt with?
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Leiden2022
Leiden was European City of Science in 2022: for a year Leiden was the capital of European science. Leiden University was a proud partner of Leiden2022.
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Growth and Transport properties of (Rare Earth)TiO3 / SrTiO3 interfaces
This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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Disrupted movement makes macrophages more lethal to tuberculosis bacteria
Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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A synthetic vaccine against meningococcus
Leiden chemists recreated the bacterial capsule of meningococcus in the lab. With a few modifications, these capsules can serve as an extra safe and effective vaccine against these notorious bacteria, which can cause, for example, meningitis. PhD candidate Jacopo Enotarpi and his team published the…
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Heterogeneity in spores of food spoilage fungi
This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.
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Neske Baerwaldt
Faculteit Rechtsgeleerdheid
n.baerwaldt@law.leidenuniv.nl | +31 71 527 2727
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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NWO grants two IBL-proposals by interdisciplinary research consortia
Recently, NWO has decided to grant two interdisciplinary research proposals for national and international consortia submitted by researchers from the Institute of Biology Leiden. One of the proposals is led by Prof. dr. Ariane Briegel, the other one by dr. Remko Offringa.
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Mosaic subsidies for highly talented ethnic minority researchers
Four of Leiden's young, talented ethnic minority graduates are to receive an award as part of the Mosiac programme of the Netherlands Organisation for Scientific Research (NWO). The award will allow these budding researchers to fund a four-year research period leading to a doctorate.
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Antibiotica Scavenger Hunt
Speurtocht
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LED3 Lecture: Natural Product Antibiotics: Past, Present, Future
Lecture
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Manipulating plant metabolomic profiles by seed and plant cutting treatments to enhance plant protection against western flower thrips
How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…
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Peter Bouwman
Science
r.j.p.bouwman@lacdr.leidenuniv.nl | +31 71 527 6105
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Babak Rezaeedaryakenari
Faculteit der Sociale Wetenschappen
s.rezaeedaryakenari@fsw.leidenuniv.nl | +31 70 800 3687
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National Meat Free Week: the main reasons to switch to a plant-based diet
National Meat Free Week (Nationale Week Zonder Vlees, 7–13 March) is an initiative to reduce meat consumption. Assistant professor Paul Behrens is studying what impact a change in our food consumption would have on the world. What, according to him, are the main reasons to switch to a (mainly) plant-based…
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Key publications
Key publications of the Antiviral Pharmacology group.
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Quantitative pharmacology approaches to inform treatment strategies against tuberculosis
Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.
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A clear picture of bacteria
Freezing bacteria super fast to gain a true-to-nature image of the internal and external structure. Ariane Briegel Professor of Ultrastructural Biology came to Leiden specially to carry out this research. Leiden University is one of the few institutes in the world to have the necessary equipment. Inaugural…
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The ecological relevance of chemical diversity in plants: pyrrolizidine alkaloids in Jacobaea species
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder