545 search results for “blood vessels” in the Public website
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Group behaviour: one for the team
Researchers at Leiden study group behaviour. One of their findings is that when people make sacrifices for another member of their group, it is probably instinctive. Insights of this kind enable us to better understand and influence the social processes in a neighbourhood or company.
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Predictive Pharmacology
Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Research
Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…
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The ANASTASIS project: Reviving Merovingian archaeology in the Netherlands
The goal of the ANASTASIS project is the analysis and publication of early medieval (Merovingian) cemeteries in the Netherlands (c. 500 – 750 AD).
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Voila/Neuromet
To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.
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Vertalen Engels-Nederlands
A language degree does not prepare you for a job as a translator, a fact unknown to graduates and their clients. Perhaps just as well, because many language graduates do become translators. The minor Vertalen Engels-Nederlands (Translation English-Dutch) offers you the opportunity to become acquainted…
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Dutch Post-war Fiction Film through a Lens of Psychoanalysis
This week 'Dutch Post-war Fiction Film through a Lens of Psychoanalysis' by Peter Verstraten was published by Amsterdam University Press, the sequel to Humor and Irony in Dutch Post-war Fiction Film from 2016. Each chapter in his 482-page new study begins with a title of Fons Rademakers who made films…
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Development of an in vitro vascular network using zebrafish embryonic cells
How can we culture an artificial vascular network to support tissue development ex vivo?
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Flora in Utopias: On Thinking Through Moving Images
How do documentary moving images and fictional narratives involve and evolve each other?
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The End of our Third Decade (volume II)
Papers written on the occasion of the 30th anniversary of the institute of Prehistory, Volume II.
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Religion and Trade: Cross-Cultural Exchanges in World History, 1000-1900
This book published by Oxford University Press discusses religion and trade in world history.
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ForSeaDiscovery - Forest resources for Iberian empires: ecology and globalization in the age of discovery
An interdisciplinary and innovative research group combining History, underwater archaeology, GIS and wood provenancing methods.
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Blood, Tears and Samurai Love: A Tragic Tale from Eighteenth-Century Japan
Lecture, LIAS Lunch Talk Series
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Veni grants for 16 Leiden researchers
Sixteen researchers at Leiden University are to receive a Veni grant from the Netherlands Organisation for Scientific Research (NWO). These awards offer promising young researchers the opportunity to further develop their own ideas over a period of three years.
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.
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Magnetic Resonance Microimaging of Alzheimer's Disease
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…
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Dynastic Identity in Early Modern Europe - Rulers, Aristocrats and the Formation of Identities
Aristocratic dynasties have long been regarded as fundamental to the development of early modern society and government. Yet recent work by political historians has increasingly questioned the dominant role of ruling families in state formation, underlining instead the continued importance and independence…
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Reactive Copolypept(o)ides as Novel Material for Systemic siRNA Delivery
The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors
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Lab facilities Developmental and Educational Psychology
Social anxiety and factors determining school success in children. Brain development in relation to cognitive, social and emotional development in adolescence.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Mathematical Institute
The Mathematical Institute is responsible for the research and education in mathematics and statistics at Leiden University.
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Measuring sulfur with satellites
Seagoing vessels may emit fewer and fewer harmful substances, but how do you measure whether they comply with the standards? The Dutch Environment and Transport Inspectorate (ILT) and the universities of Leiden and Wageningen are starting a joint study to detect the emission of sulfur and nitrogen dioxide…
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Athens
Athens is universally known as a symbol of democracy, philosophy, and ancient Greek aesthetics. Some of the most famous classical monuments, including the Parthenon and the temple of Hephaestus, can be found here.
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Vici grants for seven researchers from Leiden University
From research on stellar winds to sign language: an impressive seven researchers from Leiden University will receive a prestigious Vici grant from the Dutch Research Council (NWO).
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…
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Research methods
Because we cannot directly ask babies about what they know or what they are thinking about, we must find smart and baby-friendly ways to figure it out! Below you can read about the different methods that we typically use in our studies.
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Tell Ibrahim Awad
Update : August 2017 Dr Willem van Haarlem
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APELAFICO: Acoustic ecology of PELAgic FIsh COmmunities: A study into the effects of construction and operation of wind farms
Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?
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Why Things End
Studies on the Disappearance of the Amphora Phenomenon
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Research
Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Politics: Chinese migration
Chinese organisations increasingly operate across the borders of China, and growing numbers of people from outside China are coming to live there. Professor Frank Pieke believes these movements have a significant effect on central and local government policy in China.
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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AI in Neuroscience: Development of Methods to make Personalized Predictions for Migraine and Stroke from E-Health Sensor Data
The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.
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Minerva in her Study
Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…
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Medicine
The Faculty of Medicine
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Publications
For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.
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Cationic liposomes loaded with a synthetic long Peptide and poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell
For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…
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Babylab
Psycholinguistic research
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Protease-Responsive Targeted Delivery of Chemotherapeutics Holds Great Promise for the Treatment of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…
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LUMC first medical programme to include AI in curriculum
How do you make effective use of AI and medical technology? And what role do you play in this as a doctor? This is what the LUMC/Leiden University is preparing medical students for, right from the first year of their studies.