2,673 search results for “modelling ” in the Public website
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Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation
On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.
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signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Meta‐modelling: development of methods and tools for the exchange, analysis and communication of anonymised patient data
This project is a collaboration between Sanquin, LUMC and LIACS. It focuses on the development of meta-modelling methods and tools for the exchange, analysis, and publication of anonymised patient data. Measures are being constructed to evaluate both the level of privacy and the extent to which an anonymized…
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predictive pharmacology in children using semi-physiological population modelling: application to hepatic metabolism
Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…
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A PCAD-model for fish to study the impact of airgun sound exposure on free-ranging cod
We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.
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distribution affects permeability barrier function of stratum corneum lipid model membranes
Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463
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distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Towards a working model of industry and higher education collaboration in enhancing engineers’ soft skills for better employability
The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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Mark de Rooij
Faculteit der Sociale Wetenschappen
rooijm@fsw.leidenuniv.nl | +31 71 527 4102
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Martha Dellar
Science
m.e.dellar@cml.leidenuniv.nl | +31 71 527 2727
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New resource for the modelling community
The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Founding father of pharmacological models
After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.
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Beth Lloyd
Faculteit der Sociale Wetenschappen
b.lloyd@fsw.leidenuniv.nl | +31 71 527 2727
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Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…
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Novel system-inspired model-based quantum machine learning algorithm for prediction and generation of High-Energy Physics data
Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.
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Winner of the Model Gamification Contest
Dave R. Stikkolorum, Michel R.V. Chaudron, Oswald de Bruin won the Best Paper Award of the Model Gamification Contest at the ACM/IEEE Models 2012 Conference for their paper: The Art Of Software Design, a Video Game for Learning Design Principles.
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New flowchart to eliminate Universe models
Cosmologists have many possible models for the Universe, of which only one can be true. A new flowchart will eliminate some of them when two specific Universe features are accurately measured. Publication in Physical Review D on 7 November.
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using population pharmacokinetic and physiology based pharmacokinetic modeling approaches
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Complexity Models to Prevent Financial Crashes
The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.
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Stadium wave in the nerves: a new mathematical model
Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…
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FOM Grant for Theoretical Model Majorana Gun
Professor Carlo Beenakker has been awarded a FOM Projectruimte subsidy to build a theoretical model of a majorana gun, a very promising instrument for quantum computers.
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Fewer errors in software features by using delta modelling
When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…
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Interactive models: Matthijs van Leeuwen receives NWO TOP grant
Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Catherijne Knibbe
Science
c.knibbe@antoniusziekenhuis.nl | +31 71 527 6329
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These researchers turn mathematical models into healthcare solutions
Two Leiden researchers have demonstrated how mathematics can improve our healthcare. Daniel Gomon has developed a model that contributes to the quality of care in hospitals. Marta Spreafico works on an app that helps physicians make well-informed decisions about the treatment of a certain type of cancer.…
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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Learning from small samples
Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…
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Visualizing cityscapes of Classical antiquity
This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.
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Bioactivity based quality control for Chinese herbal medicine
Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?
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Five principles to preserve social trust in scientific modelling
Experts from several disciplines have raised concerns about the use of seemingly precise models to guide policies in matters as complex as the current Covid-19 pandemic. 22 scholars wrote down five principles on how to responsibly use scientific models. This comment was published in Nature on 24 June…
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‘Scientists should be careful when interpreting results of AI models’
Anthropologist Rodrigo Ochigame studies how AI is changing the practice of scientific research. From astrophysics to mathematics to climate science, they find that the adoption of new AI models is raising questions about what counts as reliable scientific evidence.
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Leiden econophysics model tested best by central banks
A full overview of all loans and debts between banks would help preventing a new financial collapse. But banks do not provide this information. An econophysics model by Diego Garlaschelli and collaborators reconstructs the most probable situation and finishes first place in two independent tests.
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New vegetation models can improve climate change predictions
A new study in Nature Plants has explored the most important organising principles that control vegetation behaviour. The insights from this study can be used to improve predictions on climate change. Leiden scientists Peter van Bodegom and Nadia Soudzilovskaia participated in the study.
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New Business models for the Legal Services Market
Linking Empirical Academic thinking with Legal Practice. Internationally and particularly in the Netherlands. By René Orij, April, 2016.
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How brain disorder models are like the Night Watch
Professor of Human Genetics Willeke van Roon will give her inaugural lecture on Monday 28 March entitled: ‘Translational research, where small parts make the bigger picture.’ She will emphasise how university medical centres should take responsibility for finding treatments for very rare diseases.
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A mathematical model for a more diverse workforce
Many organisations have a biased workforce, even though diversity has so many advantages. Australian and Dutch researchers, including Leiden psychologist Romy van der Lee, have developed a solution based on a mathematical model. They published their findings in PLoS One on 28 July.
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Pasteurs Cube: a new model for classifying academic researchers?
Applying a three-dimensional framework of research-related activities, Pasteur’s Cube helps to describe and study ‘use inspired’ academics at today’s research-intensive universities.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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New model predicts ‘yoyo’ orbits around black holes
Stars orbit black holes while jumping up and down. This is the prediction of a theoretical model developed by Leiden physicist Satish Kumar Saravanan, based on Einstein’s theory of relativity. He defends his PhD thesis on July 7th.
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Does a general ‘Lelystad model’ agreement have national potential?
The Municipality of Lelystad is using a new kind of council agreement: a general agreement that all parties are entitled to have their say on. As Professor of Constitutional Law Wim Voermans recently said on Dutch current affairs programme ‘EenVandaag’, this form of agreement would also lend itself…
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Roy de Kleijn
Faculteit der Sociale Wetenschappen
kleijnrde@fsw.leidenuniv.nl | +31 71 527 3915
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Fenying Zang
Faculteit der Sociale Wetenschappen
f.zang@fsw.leidenuniv.nl | +31 71 527 2727
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Zsuzsa Bakk
Faculteit der Sociale Wetenschappen
z.bakk@fsw.leidenuniv.nl | +31 71 527 8032
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Mariana Braz Pires
Science
m.braz.pires@cml.leidenuniv.nl | +31 71 527 2727
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Tales Yamamoto
Science
t.m.yamamoto@cml.leidenuniv.nl | +31 71 527 2727
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Xining Yang
Science
x.yang@cml.leidenuniv.nl | +31 71 527 2727