229 search results for “tolerance” in the Public website
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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Immune Activation and Tolerance
The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…
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Lorianne Toler-
Faculteit Rechtsgeleerdheid
l.u.toler@law.leidenuniv.nl | +31 71 527 2727
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Solvent tolerance mechanisms in Pseudomonas putida
Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.
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Ecology, Migration and Tolerance: Limits to Cooperation
Many of the most acute problems we face today are global: they transcend national boundaries, they put the future of society and even humanity at peril, and they can only be addressed through international cooperation. However, what can international cooperation deliver? Find out in the minor Ecology,…
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Tolerant migrant cities? The case of Holland 1600-1900
This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.
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The limits of tolerance: before and after Brexit and the German Refugee Crisis
This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…
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Femke Bakker, Positive Politics: How Meditation Can Help to Foster Tolerance
When we think of politics, we tend to think of adversary, antagonism, polarisation, a struggle for power. But politics should serve positive purposes, as well. Political psychologist and meditation teacher Femke Bakker (Leiden University) thinks that positive politics is first and foremost about tolerance.…
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The rhizomicrobiome of Sorghum ; impact on plant growth and stress tolerance
The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.
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Harnessing the soil microbiome for improved stress tolerance in crop plants
Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?
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Restraint under conditions of uncertainty: Why the United States tolerates cyberattacks
This new article by Monica Kaminska is part of a special issue for Journal of Cybersecurity, based on a selection of contributions from THe Hague Program for Cyber Norms' 2019 Conference.
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Neanderthals could tolerate smoke
The idea that modern humans displaced Neanderthals because they were better protected against toxic smoke components is now under fire. An earlier study that put forward this suggestion has now been refuted by genetic research by scientists from Leiden and Wageningen. This new research was published…
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Bastiaan Rijpkema appointed Professor by special appointment of Tolerance
Bastiaan Rijpkema has been appointed Professor by special appointment of the new chair Tolerance at the Faculty of Humanities with effect from 1 July 2021. The chair was established by Stichting Leerstoel Uytenbogaert.
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Diminishing tolerance in the Netherlands threat to liberal society
The Upper and Lower Houses of the Dutch Parliament are struggling with how tolerance should best be interpreted. As a result, the freedom in the Netherlands for people who hold alternative views is diminishing. This is Floris Mansvelt Beck’s conclusion on the basis of his PhD research. Defence on 2…
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Landmark ruling on tolerance agreements for Dutch ‘coffeeshops’
PhD candidate Demy Jongkind and Associate Professor Annemarie Drahmann – both part of the Department of Constitutional and Administrative Law – have been interviewed by the Kenniscentrum Europa Decentraal (KED) on the Dutch Services Act (DW) and cannabis tolerance policy.
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Bart Roep
Faculteit Geneeskunde
b.o.roep@lumc.nl | +31 71 526 3869
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Johan collaborated on three books: ‘1572 was not a celebration of tolerance’
This year marks the 450th anniversary of the Capture of Brielle by the Watergeuzen (lit. ‘Sea Beggars’) and therefore the birth of the Netherlands. Student Johan Visser is contributing to no fewer than three books about the extraordinary year of 1572.
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Johan de Fijter
Faculteit Geneeskunde
j.w.de_fijter@lumc.nl | +31 71 526 2218
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Bram Slütter
Science
b.a.slutter@lacdr.leidenuniv.nl | +31 71 527 6208
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Cornelis Hokke
Faculteit Geneeskunde
c.h.hokke@lumc.nl | +31 71 526 5065
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Microbial Induction of Plant Resilience to Drought Stress (MicroRes)
What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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About this minor
Everything you need to know about the minor Ecology, Migration and Tolerance: Limits to Cooperation.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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NWO Open Competition funding for three humanities scholars
Manon van der Heijden and Leo Lucassen, and Maarten Mous will receive NWO Open Competition funding. This funding amounts to a maximum of 750,000 euros and is intended to carry out research into a subject of their your own choice, without thematic preconditions.
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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Crime and Migration in an Age of Transformation
The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.
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Cornelis van Kooten
Faculteit Geneeskunde
c.van_kooten@lumc.nl | +31 71 526 2148
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Frank Baas
Faculteit Geneeskunde
f.baas@lumc.nl |
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Environmental and genetic drivers of wood and lignin formation in flowering plants
In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Rethinking Javanese Religion: The Prospect of New Descriptions of Javanese Traditions
This study describes religion in Java.
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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Mark van Buchem
Faculteit Geneeskunde
m.a.van_buchem@lumc.nl | +31 71 526 4376
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Conflicts between migrants and locals in Leiden and Rotterdam, 1680-1800
Due to its economic prosperity, its policy of (relative) religious tolerance, and its large numbers of migrants, the Dutch Republic has long had a reputation of being the prime example of ‘tolerance’, especially during the seventeenth century. Although the great variety of newcomers in the Dutch Republic…
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Plant-microbe interactions
Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Pleading for Diversity: The Church Caspar Coolhaes Wanted
Linda Stuckrath Gottschalk defended her thesis on 6 April 2016.
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Worm and stomach bacteria: our allies in the battle against allergic asthma
Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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Buccal and sublingual vaccine delivery
Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Ecology and conservation of spotted hyena in human dominated landscapes in northern Ethiopia
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh
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Key publications
Key publications of the Biologics Formulation group