47 search results for “nucleic” in the Public website
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LED3 Lecture: Chemical Biology of Nucleic Acids
Lecture
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
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Roxanne Kieltyka
Science
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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Biotherapeutic Delivery
The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…
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Expertise
The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Novel Chemical Modalities
The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…
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Key publications
Key research articles and book chapters of the Chromatin group.
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Joachim van Guyse
Science
j.f.r.van.guyse@lacdr.leidenuniv.nl | +31 71 527 2727
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Research
Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Synthetic peptides, nucleic acids and molecular probes to study ADP- ribosylation
PhD defence
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MCBIM Colloquium: Metal-Modified Nucleic Acids: From Silver(I)-Mediated Base Pairs to Phosphorescent Platinum(II)-Bearing DNA
Lecture
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Student projects
Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…
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Publications
Relevant publications of the CIGR participants.
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Delivery of Biotherapeutics
The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
- Publication highlights
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Research
Research at the BIOSYN group is comprised of the following research themes:
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Supramolecular materials: from biosensors to cell delivery devices
The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…
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Kistemaker obtains PhD cum laude on production of ground-breaking molecules
A month ago it was Marc Baggelaar, and now Hans Kistemaker too has obtained his PhD cum laude at the Leiden Institute for Chemistry (LIC). ‘He has made ground-breaking contributions to the world of protein modification,’ says PhD supervisor Gijs van der Marel. Kistemaker obtained his PhD on 11 May…
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
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Non-invasive DNA-labeling tool opens doors for new research
Dutch researchers have developed a new tool to label DNA for studying chromosomes in live cells. The tool is non-invasive and can be applied in culture but also in living organisms, such as zebrafish embryos. The team published their findings in the journal Nucleic Acids Research.
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Chromatin organisation & dynamics
The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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Biophysicists unravel exact folding of a single gene
The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.
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New professor of Biotherapeutics Delivery at LACDR
Matthias Barz has been appointed full Professor of Biotherapeutics Delivery at the Leiden Academic Centre for Drug Research (LACDR).
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Ten million euros for unlocking novel technologies in structural biology
The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…
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Translating science into treatments of rare metabolic disorders
Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.
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Nobel Prize winner visited Leiden: 'We have hosted a scientific rockstar'
On 28 September the famous chemists Carolyn Bertozzi visited Leiden University to speak at the LED3 seminar. Just one week later, she was announced winner the 2022 Nobel Prize in Chemistry. Leiden chemists Sebastian Pomplun and Hermen Overkleeft are fan: ‘We are extremely honoured to have hosted this…
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Leiden University strengthens its focus on Chemical Biology and Medicinal Chemistry with seven new group leaders
Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…
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Discoverer of the Year bridges science and medicine
Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…
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Not wrapping but folding: Bacteria also organise their DNA (but they do it a bit differently)
Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…
- SAILS Lunch Time Seminar: Applications of Artificial Intelligence in Early Drug Discovery
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Thiosugars: Reactivity, methodology and applications
PhD defence
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Student Talk: Venus as Potentially Habitable Planet
Lecture
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MCBIM Lecture: Supramolecular Recognition of DNA and RNA Junction Structures for Anti-viral and Anti-cancer Therapy
Lecture
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Triblock Polypept(o)ides for siRNA Delivery
PhD defence
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Joan van der Waals colloquium
The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.
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Lunch Time Seminars
The biweekly Lunch Time Seminar is an online only event, but it is not publicly accessible in real-time. If you would like to attend one of the upcoming sessions, please send an email to sails@liacs.leidenuniv.nl.