1,738 search results for “mexican drug violence” in the Public website
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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Professor Mariëlle Bruning elected Member of the Expert Group Violence Against Children of the Council of Europe (2018-2019)
Mariëlle Bruning, Professor of Child Law, is elected Member of the Expert Group on Responses to violence against children (CAHENF-VAC), which is established to assist the Ad hoc Committee for the Rights of the Child (CAHENF) of the Council of Europe.
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Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Drug development: how can we make it more efficient?
It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Jennifer Dowling
Faculty Governance and Global Affairs
j.m.dowling@fgga.leidenuniv.nl | +31 70 800 9092
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Interdisciplinary minor ’Violence Studies’: ‘It felt like we were going to fight a group of people’
The interdisciplinary, English-taught minor ‘Violence Studies’ looks at violence from very diverse scientific perspectives. What are the benefits from this approach? Students and lecturers evaluate: ‘This minor’s a goldmine’.
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Dutch people are understanding the term ‘violence’ to mean more and more
When do we say violence was used in an incident? The answer may seem obvious at first. But interim results from a study by Jolien van Breen show that Dutch people are labelling events in increasingly broad contexts as violent.
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Final report: inadequate protection from violence for children in youth care since 1945
A significant percentage of children who have spent a period in youth care institutions or foster homes since 1945 received inadequate protection from physical, psychological and sexual violence. Interventions by supervisory authorities in cases involving violence were inadequate.
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Mario van der Stelt
Science
m.van.der.stelt@chem.leidenuniv.nl | +31 71 527 4768
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Gerard van Westen
Science
gerard@lacdr.leidenuniv.nl | +31 71 527 3511
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Eline Dekeyster
Faculteit der Sociale Wetenschappen
e.a.g.dekeyster@fsw.leidenuniv.nl | +31 71 527 2727
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Roxanne Kieltyka
Science
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
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Madeline Kavanagh
Science
m.e.kavanagh@lic.leidenuniv.nl | +31 71 527 3527
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Is the WPS Agenda Working? Preventing Conflict Related Sexual Violence and Beyond
On Wednesday 25 January, the British Embassy, the Global Transformations and Governance Challenges (GTGC) programme at Leiden University and Women in International Security Netherlands (WIIS-NL) were hosting a round table with Professor Bina D’Costa to discuss the prevention of conflict related sexual…
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Carlotta Rigotti and Gianclaudio Malgieri on sexual violence and harassment in the metaverse
On 24 April 2024, Carlotta Rigotti and Gianclaudio presented their new report on sexual violence and harassment in the metaverse during a webinar co-organised by AUDRi, Equality Now, and VULNERA.
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Social Resilience and Security
Social resilience and security has never been more important. Over the last 2 years, the COVID-19 pandemic has created a considerable disturbance to our personal and social lives. As a result, the general population reports more stress, loneliness and decreased quality of life. At the same time, there…
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Dennis Bos
Faculty of Humanities
d.bos@hum.leidenuniv.nl | +31 71 527 2722
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May Tamimová
Faculty Governance and Global Affairs
m.tamimova@fgga.leidenuniv.nl | +31 70 800 8206
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Lenneke Alink
Faculteit der Sociale Wetenschappen
alinklra@fsw.leidenuniv.nl | +31 71 527 3432
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Politie & wetenschap
Terrorism experts Daan Weggemans (Leiden University) and Beatrice de Graaf (Utrecht University) conducted one of the first scientific studies on the societal reintegration of jihadist former detainees. They showed that the reintegration process isn't without problems. Their conlusions are presented…
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Vidi grant for Esther van Ginneken for research into violence in prisons
Why do violent incidents occur in prisons? And how do staff respond? Assistant Professor Esther van Ginneken will use a grant from the NWO Vidi Talent Programme to conduct research into these and other questions. She intends to make use of virtual reality.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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LUF lustrum grants: research into lethal violence and deaf families in Africa
Research into 25 years of lethal violence in the Netherlands and into language socialisation of deaf families in Africa will receive grants from the Leiden University Fund (LUF).
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Research projects
Research within COI@Leiden is clustered around two themes: sustainable justice and the courtroom as a social arena. Find out more about each of these projects by clicking on the links below.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Pregnant and drug dependent: Ministry of Justice tries to intervene with prosecution
Drug use during pregnancy seems like a choice without any consequences. However, the Dutch Public Prosecution Service (OM) has decided to prosecute a mother for using alcohol and drugs during her pregnancy. Mariëlle Bruning, Professor of Child Law, tells current affairs programme ‘Nieuwsuur’ that she…
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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The Practitioner’s Guide to the Galaxy – A Comparison of Risk Assessment Tools for Violent Extremism
This paper critically compares seven widely used risk assessment tools for violent extremism, including the VERA-2R, the ERG 22+, the SQAT, the IR46, the RRAP, the Radar, and the VAF.
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Does Terrorism Dominate Citizens’ Hearts or Minds?
Terrorism only poses a small risk to people but tends to be a major source of public fear. Through fear, terrorism has far-reaching implications for public governance.
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Alumnus Robert Ietswaart: ‘Machine learning is revolutionising drug discovery’
Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Fighting cancer with light (and a drug that self-assembles into nanoparticles)
Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…
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Using AI to Combat Drug Resistance - an Interview with PhD student Rosan Kuin
Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…
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A Persistent Revolution: History, Nationalism, and Politics in Mexico since 1968
A Persistent Revolution: History, Nationalism, and Politics in Mexico since 1968
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…