667 search results for “soil bacteria” in the Public website
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Workshops & Demo's
During the Leiden Science Family Day, you can take part in various workshops. You can also watch various demonstrations. Where will you go?
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
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Host-Microbe Interactions in Microbial Sciences
Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Six million boost to search for new antibiotics
Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.
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TERRA: TERraced landscape of RAmosch, Switzerland
This project investigates the well-preserved agricultural terraces of the Inn valley and the evolution of resource use in the inner Alps.
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Development of life cycle assessment for residue-based bioenergy
Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs
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Microbial protection of food crops and human health
We investigate bacteria and fungi to understand their malicious or beneficial impact on food crops and their pathogenic or antibiotic role in human health.
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…
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Microbial Chemotaxis
In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.
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Leiden2022
Leiden was European City of Science in 2022: for a year Leiden was the capital of European science. Leiden University was a proud partner of Leiden2022.
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Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes
Almost all bacteria are enveloped by a cell wall that provides cellular protection.
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
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Bacterial Chromatin
The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…
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Antibiotic combination therapies against drug resistant Gram negative pathogens
Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Cellular Forces: Adhering, Shaping, Sensing and Dividing
Promotor: Prof.dr. T. Schmidt
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Simulation of infant gut makes predictions about optimal milk
David Versluis successfully simulated an infant gut virtually. This is crucial for research on improvements in formula milk. Currently, such research primarily relies on diaper contents, which is not optimal. Versluis defended his doctoral thesis on April 23.
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Inaugural lecture: Innate immunity into the picture
Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…
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Microbes protect crops from microbes
Farmers do not love them all. Microbes can cause tragic consequences for crops. Even the presence of just one pathogenic fungus or bacterium can drastically reduce yields. Still, there are exceptions. In that case, a pathogenic microbe is present in the soil, but does not cause any harm. Adam Ossowicki…
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MicroGRICE: Greenhouse Gas Reduction in RICE: MICRO-biome climate smart applications
Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Improving Nature’s Antibiotics to Overcome Resistant Bacteria
Lecture, NGL-lezing
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Victor Klinkenberg
Faculteit Archeologie
m.v.klinkenberg@arch.leidenuniv.nl | +31 71 527 2727
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Manipulating plant metabolomic profiles by seed and plant cutting treatments to enhance plant protection against western flower thrips
How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…
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Microbial Sciences
In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Greenifying industrial biotechnology through the creation of synthetic endosymbionts
Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?
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Spatial populations with seed-bank
In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays
Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Annual report CML 2016
In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…
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Ecotox
Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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Evolution & Biodiversity in Microbial Sciences
Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.
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Advanced Pre-clinical Evaluation of the Guanidino Lipoglycopeptides: A Novel Family of Glycopeptide Antibiotics with Best-in-Class Potential
Can we make a better vancomycin?
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'A garden on Mars' crowdfunding campaign starts today
Today, 13 students at Leiden University have started a crowdfunding campaign to collect money for research into the possibilities of growing crops on Mars. Their research will contribute to the knowledge of our galaxy. The project is in the context of the iGEM competition.
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Dating with electrodes struck to your skin
Four thousand visitors immersed themselves in art and science during Leiden's Night of Art and Science on 17 September. They could choose from dozens of lectures, experiments, interactive events and a lot of art.
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Knowledge from now
Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.
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Institute of Environmental Sciences (CML): best institute for quantitative environmental issues
A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.
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Plant Sciences
The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…
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TRIPS: Thrips Reduction In Production Systems
Increasing above- and belowground biodiversity in arable leek cultivation to stimulate pest control by natural enemies.
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…