3,259 search results for “this week s discoveries” in the Public website
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Projects
The Young Academy Leiden and its workgroups have launched different initiatives in the interest of early-career scholars. Read all about the different projects of the Young Academy Leiden here.
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Applied String Theory: Explaining Quantum Matter with Black Holes
Schalm
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Island Networks
The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Grants & Awards
Grants awarded to molecular physiology research
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Key publications
Key publications of the Cancer Drug Target Discovery group
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LED3 Lectures
The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…
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Leiden master's student in Labour Law is ‘student intern of the week’ in Dutch magazine Mr.
Eva Lammers is currently studying for a master's degree in labour law at Leiden University and expects to graduate in autumn 2023. Lammers did her internship at law firm JPR in Deventer and was thrown in at the deep end from the start. 'Assignments aren’t arranged for you, you've got to arrange them…
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
PhD defence
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LED3 Chemical Biology Talk: Cyclic Peptides in Target Discovery
Lecture
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Antibiotic Discovery: From mechanistic studies to target ID
PhD defence
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
PhD defence
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specialist Ton Koopman returned to the San Francisco Symphony for two weeks
Leiden University Professor and world renowned Bach specialist Ton Koopman returned to the San Francisco Symphony for two weeks of concerts celebrating J.S. Bach and his legacy.
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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AiChemist project
The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…
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The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
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Saqqara Project 2019
This week the good news broke as the Egyptian authorities have given their permission to continue the excavations in Saqqara in 2019!
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Glyco(proteo)mic Workflows for Cancer Biomarker Discovery
PhD defence
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From data to discoveries: machine learning and optimization in space
Lecture
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Top 450
What is the best thing ever about Leiden University?
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Bioactive Molecules
Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.
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Education
Studying linguistics at the Leiden University Centre of Linguistics (LUCL) is a challenging but rewarding experience. There are few places in the world where such a broad range of languages are studied from so many different perspectives.
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Master Students MPS Hold up Mirrors in front of Managers during Shadow Week
How do you bring education and practice closer together? In the revised Master MPS (Management of the Public Sector) it is done, for example, through the new profile course Leadership & Behaviour inside and between organisations. The Leiden Leadership Centre (LLC) is involved in organising the course.…
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A Successful Week in Washington D.C. for Moritz Jesse - Lectures, book presentation and Moot Court
One Lecture about Immigrant Integration in the EU and its Member State at the Institute of European Studies at George Washington University, one class in a course on Immigration and Integration at Georgetown University, and a lot of judging in the international rounds of the Phillip C. Jessup International…
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Shadowing council boss for a week: 'I saw him mostly putting out a lot of fires'
After a week of shadowing for her master's degree in Public Sector Management, it has become very clear to student Loes what a manager's day looks like. 'He was putting out fires all day.'
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Leiden planetary experts want to study seven ‘Earths’ in more detail
Astronomers have discovered seven Earth-like planets around a dwarf star in our galaxy. Three of these planets are located in the habitable zone of this star, and may contain liquid water. ‘The next step is to study the atmospheres for signs of life. In Leiden we are experts in that area,‘ says planetary…
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Sabine Witting
Faculteit Rechtsgeleerdheid
s.k.witting@law.leidenuniv.nl | +31 71 527 8838
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Master student Maddalena Centanni awarded with Arenberg-Coimbra Group Prize
Former masterstudent Bio-Pharmaceutical Sciences Maddalena Centanni will be awarded the 2020 Arenberg Coimbra Prize for Erasmus Students. Centanni spent her six month Erasmus exchange at Uppsala Universiy in Sweden where she looked for ways to improve anti-cancer drug dosing.
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Discovering and developing drugs
Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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already going to see this effect of the coalition agreement in the coming weeks'
Few details, relatively few words. The coalition agreement presented is one of the shortest in the past 20 years, Arco Timmermans knows. Consequently, the outlines were not negotiated for very long, which has its advantages and disadvantages. 'Over the next few weeks, we are mainly going to see the…
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How Oncode-PACT is bringing new cancer medicines closer with 325 million in Growth Fund money
How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Leiden Academic Centre for Drug Research
Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
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Molecular Physiology
Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.