611 search results for “random matrix theory” in the Public website
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Human skin equivalents: understanding the lipid biosynthesis in the skin
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
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Group representations in Banach spaces and Banach lattices
Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter
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Development of formulation for treatment of Atopic Eczema
description that google uses to depict when in presented in search results
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Nano-scale electronic structure of strongly correlated electron systems
In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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On p-adic decomposable form inequalities
Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier
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LCN2 Seminar: Mixing of random walks on dynamic graphs with a fixed degree sequence
Lecture
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Pellikaan & Van Willigen, Bilateralism and Nuclear Security
Political scientists Huib Pellikaan and Niels van Willigen (Leiden University) use and elaborate on the theoretical insights from game theory in order to understand nuclear security in changing environment. Now that the relations between the US and Russia have deteriorated and smaller nuclear states…
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Patterns in natural systems
Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris
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e-Coach: Tailored cognitive-behavioral e-Health care for patients with chronic somatic conditions
The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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The SMILE study: Sleep Mood lntervention: Live Effectively a group intervention in students with sleep problems
Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?
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Anisotropic Colloids
While colloidal aggregates are often undesirable due to their random shapes, we exploit them as a starting point to synthesize patchy particles.
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Book: Edwin Bakker - Terrorism and Counterterrorism Studies: Comparing Theory and Practice
Professor Edwin Bakker, director of the Centre for Terrorism & Counterterrorism, released his new book “Terrorism and Counterterrorism Studies: Comparing Theory and Practice”, published by Leiden University Press.
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Jelle But, Demy Jongkind, and Wim Voermans publish in The Theory and Practice of Legislation
The most recent edition of the journal ‘The Theory and Practice of Legislation’ contains a contribution by Jelle But, Demy Jongkind and Wim Voermans.
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LCN2 Seminar: Discordant edges for the voter model on regular random graphs.
Lecture
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Tom Louwerse, 'Improving opinion poll reporting: the Irish Polling Indicator'
Article in the journal Irish Political Studies discussing the challenge of aggregating opinion polls and presenting a method to better model major sudden political and societal events. This can can enhance opinion poll reporting in the media.
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Dancing with the Stars
This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.
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About LCN2
Mission statement
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Dimensions of Free Speech: An Exploration of a New Theoretical Framework
In ‘Dimensions of Free Speech’, Devrim Kabasakal Badamchi (Leiden University Institute of Political Science) offers a new theoretical framework for free speech by critically analysing the major justifications for free speech. Kabasakal Badamchi argues for a justification: namely the double-grounded…
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Into the Darkness: Forging a Stable Path Through the Gravitational Landscape
In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.
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Beyond Dissemination: Hindustani Identifications at the Nexus of Tradition and Modernity
An interdisciplinary cultural analysis of how the Hindustani double migration informs contemporary processes of identification and problematises the juxtaposition of tradition and modernity.
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Reasons and Intentions
There are a number of problems in philosophy that seem to share a similar possible solution: 'Why do promises and contracts bind?', 'Why ought citizens and judges obey the law?' and 'Can we realize the gains to be made from cooperation?'. All three problems (as well as some others) share a possible…
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Surface Temperature and the Dynamics of H2 on Cu(111)
Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…
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Daan Pelt brings theory and practice together in the field of Deep Learning
Bringing the theoretical world of mathematics and computer science to more applied research areas. That is what Daan Pelt, assistant professor at the Leiden Institute of Advanced Computer Science (LIACS) is trying to achieve with the methods he is developing as a solution to challenges in image proc…
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Charlotte wins thesis award on argumentation theory: ‘This is one way to strategically pin someone down’
Everyone has heard arguments like this before as a child: ‘Whether you like it or not, you have to go to school!’ It seems as though you are presented with two options, but there is only one real outcome. Charlotte van der Voort of the MA Dutch Studies won the Leiden University Thesis Prize on her research…
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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On continued fraction algorithms
Promotor: Robert Tijdeman, Co-promotor: Cornelis Kraaikamp
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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The Encyclopedia of Global Human Migration
The Encyclopedia of Global Human Migration provides a complete exploration of the prominent themes, events, and theoretical underpinnings of the movements of human populations from prehistory to the present day.
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Global Fields and Their L-functions
Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.
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Transvac2
TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…
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Things hold together: Foundations for a systemic treatment of verbal and nominal tone in Plateau Shimakonde
This is a study of Plateau Shimakonde, a sub-dialect of the Makonde language which is spoken on the Makonde Plateau in northern Mozambique.
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The role of lipids in the barrier function of the skin
The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…
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Resumptive Prolepsis. A Study in Indirect A'-Dependencies
This dissertation investigates A'-dependencies in Standard German, Zurich German and Dutch where the dislocated constituent is indirectly, i.e. not transformationally, related to the position where it is interpreted. The analysis is carried out within the Principles & Parameters framework.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Why Leiden University
Leiden University provides ambitious students with the most recent and innovative areas of knowledge, and offers them the freedom to develop their own area of expertise.
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Therapeutic intervention to enhance atherosclerotic plaque stability
Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Modern Perceptions of Ancient Religions
The aim of this Research Traineeship will be to analyze the underexplored reception of ancient religions in popular culture, taking Dutch spiritual magazines as a case study. There are five such magazines: Paravisie (1986- ), Paraview (1997- ), Happinez (2003- ), Bres (1965- ), and Prana/Mantra (1975-…
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Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.
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Positive representations on ordered Banach spaces
Promotor: A. Doelman, Co-promotor: M.F.E. de Jeu
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Architecture. Paestum in Eighteenth-Century Architectural Experience and Theory'
The 18th-century rediscovery of the three archaic Greek-Doric temples in Paestum in southern Italy turned existing ideas on classical architecture upside down...