534 search results for “genome organization” in the Public website
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Leiden scientists develop topological barcodes for folded molecules
The team of Alireza Mashaghi at the Leiden Academic Centre for Drug Research has found a way to determine and classify the shape of proteins. Their new theory defines the topology of proteins as a simple and precise barcode that allows the identification of all types of folds. ‘This barcode enables…
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New technique offers chemists unprecedented control in drug research
Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…
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How our single-celled relatives package their DNA
A group of single-celled organisms organises its DNA in a similar way to higher organisms such as plants, animals, and fungi. However, the way packaged DNA is read out differs between the two related groups, Bram Henneman discovered. PhD defence on 5 December.
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Ancient DNA reveals impact of the “Beaker Phenomenon” on prehistoric Europeans
In the largest study of ancient DNA ever conducted, an international team of scientists has revealed the complex story behind one of the defining periods in European prehistory. The study is published this week in the journal Nature.
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5.7 million for future-proof lettuce varieties
A new 5.7 million euro research project will ensure that lettuce will be more resistant to pathogens and climate effects and will grow better in new cultivation systems. Together with other Dutch researchers, Leiden biologists will map the characteristics and genetic information of 500 wild and cultivated…
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How animals flirt with each other
How do animals choose their partners? The answer is simple: it’s all about quality. While humans tend to wear clothes that happen to be in fashion, animals do nothing without a reason. Behind beautiful plumage or a deafening roar is only one message: I am in great shape. The evolutionary courtship displays…
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Spinoza Prize for Michel Orrit, Professor of Spectroscopy
It is partly thanks to Leiden professor Michel Orrit that we are today able to study individual molecules. He just missed winning a Nobel Prize, but is today the recipient of another important scientific award: NWO’s prestigious Spinoza Prize.
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Collaborating on big data to unravel disease processes
Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.
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ESOF ‘Art Exploring Science’ session will connect art and science
How can we view societal challenges from a different perspective? At the EuroScience Open Forum (ESOF), Robert Zwijnenberg, Emeritus Professor of Art and Science Interactions, will call for more collaboration between artists and scientists.
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Two research schools partnered with Leiden University participate in Graduate Programme
The Casimir Research School and the Graduate School Experimental Plant Sciences will be participating in the first Graduate Programme. This was announced on Wednesday 12 August by Minister Plasterk (Ministry of Education, Culture and Science). Leiden University is a partner in both schools. Nine Dutch…
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From droplets in the freezer to the inception of a potent new antibiotic
What started as an idea during a social gathering led to an unexpected breakthrough in research on resistant bacteria. Biologists and chemists from Leiden developed a new substance that proves to be effective against bacteria resistant to antibiotics. They published their discovery in Nature Chemist…
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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Florence Nightingale Colloquium
Lecture, colloquium
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Determining global distribution of microplastics by using citizen science
The objective of this study is to better understand the distribution of microplastics in the environment. More specifically, we will quantify the abundance and distribution of microplastics on beaches.
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Inclusive Peace in Ukraine
Debate, Panel Discussion
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Algorithm for Structural Variant Detection
PhD defence
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Diversity of glucocorticoid signaling
PhD defence
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A global analysis of matches and mismatches between human genetic and linguistic histories
Lecture
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LED3 Lecture: Probing the human proteome for therapeutic opportunities
Lecture
- IBL Spotlight - Evolution and Biodiversity
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Statistician Aad van der Vaart Knight in the Order of the Dutch Lion
During a symposium in honour of his 60th birthday, statistician Aad van der Vaart received the royal award of Knight in the Order of the Lion of the Netherlands. Colleagues talk about his significance for their field and how they got to know him. ‘The collaborations with Aad have been one of the great…
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Integrating data to learn more
Tremendous amounts of data are generated in scientific research each day. Most of this data has more potential than we are using now, says Katy Wolstencroft, assistant professor in bioinformatics and computer science. We just need to integrate and manage it better.
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IBL Spotlights - Development & Disease
Lecture
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MCBIM Lecture: Supramolecular Recognition of DNA and RNA Junction Structures for Anti-viral and Anti-cancer Therapy
Lecture
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Metagenomic sequencing in clinical virology: advances in pathogen detection and future prospects
PhD defence
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Secure and Efficient Computing on Private Data
Lecture
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Expanding the chemical space of antibiotics produced by Paenibacillus and Streptomyces
PhD defence
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Multidisciplinary dialogues on the human past of the Urubamba/Ucayali basin: towards a new synthesis
Conference
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Medical Delta Professor Eline Slagboom: ‘The delta region is where everything comes together’
Professor Eline Slagboom has been studying multiple generations of families for over 20 years. She collects data on why some people age healthily and others decline early.
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Veni grants for 16 Leiden researchers
Sixteen researchers at Leiden University are to receive a Veni grant from the Netherlands Organisation for Scientific Research (NWO). These awards offer promising young researchers the opportunity to further develop their own ideas over a period of three years.
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Theses
Below thesis archives will be moved shortly (work in progress) to the Leiden Repository. Once this is done, theses submitted by MI students (from 2008 onwards) can be accessed via the Repository and will be removed from this site.
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To do a PhD or not to do a PhD? Speed date about it with alumni!
Career and apply for jobs
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Older publications
Overview of the publications of the department of Environmental Biology (1972-2015)
- Program 2024