The research of our group is centered around dynamical systems, functional analysis and their interplay.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotor: S.M. Verduyn Lunel

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

Promotor: W.Th.F. den Hollander

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Unfolding potential

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

An assessment approach that tailors to children’s instructional needs

Can dynamic testing provide us with insight in children’s potential for learning?

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

This thesis introduces the concept of

Promotor: Prof.dr. M. Danhof

Developing methodes to understand the evolution of patches in natural ecosystems

In this unique collaboration between Leiden University, Delft University of Technology and Erasmus University Rotterdam and building on the goals set in the African Union Agenda 2063 the United Nations Agenda 2030, the multidisciplinary minor African Dynamics fosters a deeper understanding of integrated…

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: J.W. van Holten

Promotor: Huub de Groot, Co-promotor: Francesco Buda

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Does a moving hybrid zone leave a genomic footprint?

John van Noort

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).