1,856 search results for “single molecule spectroscopy” in the Public website
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Research
Research at the SBC group is comprised of the following research themes:
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Cold gas in distant galaxies
The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Geert-Jan Kroes
Science
g.j.kroes@chem.leidenuniv.nl | +31 71 527 4396
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Annemarie Meijer
Science
a.h.meijer@biology.leidenuniv.nl | +31 71 527 4927
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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The evolution of the diversity of secondary metabolites
Why do plants produces always produced so many slightly differing metabolites within a particular chemical class?
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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From Star-formation to Recombination: Expanding our View of the Radio-Recombination-Line Universe
The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).
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How do you recognise the atmosphere of extraterrestrial lava worlds?
In the past 30 years, over 5,000 planets have been discovered outside our solar system. One common exoplanet is the lava world, a hot super-Earth with oceans of liquid lava. Mantas Zilinskas developed models to simulate possible atmospheres of these. Those simulations provide guidance for astronomers…
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Exo-planets, star and planet formation
At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars (exoplanets). They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems. This way they address…
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Solvent effects in the electrocatalytic reactions of water
Koper
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Arthur Ram receives NWO grant to improve enzyme factory
This year, microbiologist Arthur Ram will start new research on producing useful enzymes in bulk. Ram receives an NWO grant for this project that will find its applications in the industrial biotechnology and food industry.
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Steps in gas-surface reactions
Heterogeneous catalysis is essential to many industrial applications. These catalysts are often comprised of supported nanoparticles, which contain various different surface sites.
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Facilities
Our facilities cover:
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Bernhard Brandl
Science
brandl@strw.leidenuniv.nl | +31 71 527 5830
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Research methods
Because we cannot directly ask babies about what they know or what they are thinking about, we must find smart and baby-friendly ways to figure it out! Below you can read about the different methods that we typically use in our studies.
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IBL Spotlight - Bioactive Molecules
Lecture
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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The quantum computer
The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…
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The mechanical genome : inquiries into the mechanical function of genetic information
The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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Early stellar galaxies
Franx
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Rob Verpoorte receives prestigious pharmocognosy award
The American Society of Pharmacognosy (ASP) has given the Varro E. Tyler prize to Rob Verpoorte, for his outstanding lifetime contributions to the science of nature as source of medicine.
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Leiden Institute of Physics
Research at the Leiden Institute of Physics (LION) is foundational and curiosity driven. All our scientists share a desire to increase the knowledge of the world around us, in an open atmosphere of inquiry from which innovative ideas emerge that provide applications and value for society.
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Key publications
Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)
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Overcoming the Debye screening length with radiofrequency-operated graphene biosensors
Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?
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DNA expressions - A formal notation for DNA
Promotores: J.N. Kok, H.J. Hoogeboom
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Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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2019
What is the difference between highly visible and poorly visible monuments on the alignment? And is this difference reflected in the social position of the dead buried underneath these mounds.
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Tracing space ice and the building blocks of life
An unprecedented space telescope, an astrolab that makes space ice and molecules that may lead to the origin of life… The Ice Age project has all the prerequisites to become a very fascinating research project – if it is not one already. Leiden astronomers Melissa McClure, Harold Linnartz and Will Rocha…
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Quantum Matter and Optics
Research groups in the Quantum Matter & Optics programme investigate electronic properties of matter and light-matter interactions with emphasis on quantum information.
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Frontiers in surface scattering simulations
Theorists have recently made substantial progress in simulating reactive molecule-metal surface scattering but still face major challenges. The grand challenge is to develop an approach that enables accurate predictive calculations of reactions involving electronically excited states with potential…
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Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Unlocking the chemistry of the heavens
How are the building blocks of life formed?
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Understanding membrane fusion at the molecular level using a biomimetic model system
How can the transport of molecules in living cells help to target medicines at exactly the right place?