This is a joint PhD of the Faculty of Social and Behavioral Sciences at Leiden University and the Evolutionary Ecology Group at Antwerp University.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

How have human-environmental entanglements changed in the Gulf of San Miguel, Darien, Panama, from the first traces human practices through to the present?

Analysis of drug adversity

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

The Master’s Information Day Leiden University – Campus The Hague will be held on 6 November. The presentations will be given at the Schouwburgstraat 2 in The Hague.

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

How can zebrafish research help to understand and fight human cancer?

When do fire making tools appear in prehistory, and how might the use of these tools manifest in the archaeological record?

In Humanity’s End As A New Beginning, Emeritus Professor Mineke Schipper reflects on myths about ‘the end’.

Does foreign aid promote human rights?

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Keynote Lecture

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…

This summer school focuses on the emergence of sexual orientation, gender identity (SOGI) and intersex issues in different areas of international law, such as human rights law, refugee law, international economic law, and international criminal law. Further information for this summer course will be…

Eduard Fosch-Villaronga, Associate Professor at eLaw, contributed to 'Cyber–Physical–Human Systems', a book exploring the latest developments in interactions between cyber–physical systems and humans.

Imagining Urban Complexity introduces passionate and critical perspectives on the link between the humanities and urban studies.

Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

On Thursday 20 May 2021, Tania Li delivered the annual Van Vollenhoven Lecture.

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

You can ask virtual assistant Siri about the weather, but you can’t have a real conversation with it yet. You can’t refer to anything that’s been said before, or ask the system why it says what it says. Stephan Raaijmakers, Professor by Special Appointment from TNO, hopes to change this.

PhD defence

Leiden University’s Campus the Hague is soon to expand into the Central Innovation District in the centre of The Hague. Plans are under way for a Campus boulevard with a new University building in the area between the Prins Bernhardviaduct and Schedeldoekshaven.

Various internal and external parties are involved in the redevelopment of the Witte Singel Doelen Complex.

Leiden University is working on the renovation of the Humanities Campus. The education buildings are being addressed one by one. Students, staff, visitors, and Leiden residents can then study, work, and live in a pleasant environment. The Humanities Campus is in open connection with the city of Leiden…

On Monday 28 September, the University Council (UR) will discuss the Development Strategy and the Implementation Plan for Leiden University's Campus The Hague 2020-2030. The plan will then be put on the agenda of the meeting of the UR with the Executive Board on 12 October. After this, the plans for…

If an algorithm has to learn to understand language, simply having a lot of data doesn’t help much. Like us, a computer has to learn the language in interaction with others. Tessa Verhoef is fascinated by how this interaction works.

In the last weeks, ASEAN published different Statements about the human rights situation in Myanmar and the Democratic People´s Republic of Korea (DPRK).

The university campus at Leiden Bio Science Park will change rapidly over the next few years. A short film shows the transformation to a full campus. See what this mix of new university buildings, student accommodation and restaurants and cafés will look like. And sustainability and biodiversity won’t…

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

Promotores: G.R. de Snoo, B. Sinsin, Co-Promotor: H.H. de Iongh

To celebrate the end of the semester the Science and Humanities Buddy Programme organised a barbecue together, which has become a small tradition. The barbecue marks the third co-organised activity between the two Programmes and helps to bring international and Dutch students together. The Buddy Programme…

The Sackler Distinguished Lecture Series on Human Rights was established at Leiden University through an endowment given by Dr. Raymond R. Sackler and his wife, Beverly, international philanthropists with a commitment to supporting scientific research. The lectures mark the annual celebration of International…

‘We’re going to see each other again on campus. We’re so pleased, but we do have to say safe.’ Rector Magnificus Hester Bijl is looking ahead to the new academic year, which begins on 6 September. No more 1.5m distancing, but we do have to take responsibility for other people’s safety.

Since the emergence of humankind people have maintained social contacts and traveled widely, establishing interaction networks in which goods are traded and ideas are transmitted, increasingly on a global scale.

Making public space more sustainable is considered very important in this project. The Humanities Campus will become a pleasant place to spend time, with lots of greenery. Here, people can relax and find coolness on hot summer days.