2,595 search results for “computer aided drug design” in the Public website
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Assessment of early-stage coronary atherosclerosis on quantified coronary computed tomography angiography
PhD defence
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Schuurmans appointed Chair of Legal Aid Board’s Advisory Council
Ymre Schuurmans, Professor of Constitutional and Administrative Law, has been appointed Chair of the Dutch Legal Aid Board’s Advisory Council following permission from the Dutch Minister for Legal Protection.
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Light on the quantum computer
Physicist Martin van Exter works with light at nanoscale, at the forefront of nanocomputer research. But as Director of Education he also has a vision for physics teaching. Inaugural lecture 18 November.
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Research Design in Political Science: The new book by Dimiter Toshkov is now out
The new book by Dimiter Toshkov - associate professor of Public Administration at the Faculty of Governance and Global Affairs - has been recently published by Palgrave Macmillan.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Design, synthesis, and evaluation of antigenic peptide conjugates containing Toll-like receptor agonists
This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.
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New project uses artificial intelligence in drug development
In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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High-field neuroimaging of computational processes that drive cognitive control.
How do humans control their thoughts and actions, and what can high-field brain scanning reveal about the underlying processes?
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the role of Dutch Intelligence Services (AIVD) in the fight against drug trafficking
Minister Grapperhaus wants to use intelligence services in the investigation of drug crime. There are many doubts about this wish in the intelligence world. Paul Abels, Professor by Special Appointment Governance of Intelligence and Security Services at the Institute of Security and Global Affairs (ISGA),…
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Paul Adriaanse
Faculteit Rechtsgeleerdheid
p.c.adriaanse@law.leidenuniv.nl | +31 71 527 2727
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Quality-driven multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Safe and Sustainable by Design framework for the next generation of Chemicals and Materials (SSbD4Chem)
How can the Safe and Sustainable by Design (SSbD) framework developed in the SSbD4CheM project facilitate the creation of safer and more sustainable chemicals and materials across various industries?
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Designating Place: Archaeological Perspectives on Built Environments in Ostia and Pompeii
Spatial analysis on the basis of material culture has always been one of the major topics in archaeological research. Designating Place analyses the urban space of Roman Ostia and Pompeii in different ways, namely via geophysical analysis, spatial analysis, iconographic analysis and epigraphic analy…
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Design, implementation and evaluation of transnational collaborative programmes in astronomy education and public outreach
Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek
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Bob van de Water
Science
water_b@lacdr.leidenuniv.nl | +31 71 527 6223
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New measuring method facilitates drug research
Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.
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Predicting drug behaviour in the brain
Does a drug enter into the human brain once administered in the body?
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Artificial intelligence as the co-pilot for drug discovery
There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…
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ELS first aid kit for doctrinal legal scholars
Empirical legal studies is receiving more and more attention. At Leiden Law School, we have chosen the topic ‘markets, behaviour, and the regulatory role of the law’ as starting point to advance our empirical legal research. The goal is to bring together legal scholars and social scientists from across…
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Experimental drug BIA 10-2474 deactivates proteins in human nerve cells
At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…
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Bringing science to practice: Designing an integrated academic education program for public affairs
Arco Timmermans, Professor by special appointment Public Affairs at Leiden University, brought sience to practice by designing an “ideal” academic education programme on public affairs, to be embedded and taught at the graduate level.
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The body's own marijuana as inspiration for drug research
Endocannabinoids - the body's own marijuana - are promising departure points for drug research. Professor of Molecular Physiology Mario van der Stelt examines whether inhibiting their production can be a way to fight inflammatory brain disease and to combat obesity. Inaugural lecture 19 October.
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Psychologist writes sober book about psychedelic drugs
Psychedelic drugs like magic mushrooms and LSD are embraced by some and seen as lethal by others. Cognitive psychologist Michiel van Elk delved into the world of psychedelic drugs and wrote a surprisingly sober book about them. ‘Without first-hand experience my story wouldn’t be complete.’
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Design for the Future: Wicked Environmental Problems in Sustainability and Health
How do we approach education that facilitates creative confidence for students that leads to innovative solutions to society’s present day and future sustainability challenges? This education research project tackles a sustainability dilemma faced by households in everyday life viz.
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Felix Frohnert
Science
f.frohnert@liacs.leidenuniv.nl | +31 71 527 2727
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Medical Delta AI for Computational Life Sciences
The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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New practice tool for quantum computer coding: OpenFermion
In a global effort, quantum computers are rapidly being developed. In the meantime, researchers have to learn how to write code for these devices, which are fundamentally different from conventional computers. A collaboration of scientists led by Google, and including physicists from Leiden and Delft,…
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SPOT ON: Students with Perspective in Education and Future. Design Principles and Networks
The central issue of this research concerns how students can best be supported in their study choice, study career and future orientation with a view to flexible entry and transitions and perspective in education and work.
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New memory developed for superconducting computer
If computers work on superconducting current, they won’t consume any energy. Leiden physicists have now gained control over a new type of superconducting memory elements. Publication in Nature Communications.
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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How Leiden's drug pioneers have switched to Covid research
From studying molecules in the blood of corona patients to developing a new concept for vaccines. The Leiden Academic Centre for Drug Research (LACDR) has transformed many ongoing projects into Covid research projects. Hubertus Irth, scientific director of LACDR, talks about the role of his institute…
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Design, synthesis and application of sulfur-containing heterocycles as potential inhibitors of glycosidases and glycosyltransferases
PhD defence
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Algorithm Design for Mixed-Integer Black-Box Optimization Problems with Uncertainty
PhD defence
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Efficient Constraint Multi-Objective Optimization with Applications in Ship Design
PhD defence
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policing: achieving norm internalisation and compliance with persuasively designed technology
PhD defence
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From scientific idea to promising new drug
Many pharmaceutical companies no longer have their own lab and are working more closely with universities and start-ups of scientists. Professor of Science-Based Business Simcha Jong is researching how scientific ideas result in new drugs, including at the Leiden Bio Science Park (LBSP).
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market needs: new course for master’s students focuses on quality in drug development
Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…
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Computers help wood anatomists with wood identification
The most commonly used method for the taxonomic identification of tree trunks is wood anatomy. The number of experts in this area is decreasing, and education to become an wood anatomists takes many years. With the help of technology computer scientists of the Leiden Institute of Advanced Computer Science…
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NMR Facility
Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…
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NWA funding for communications research on quantum computing
Leiden physicist Julia Cramer receives 50 thousand euros in funding for 'Let's talk about quantum', a research project on communication about quantum computing. A project for high school students by education expert Henk Buisman is also included in the NEWA ELSA funding.
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Roy de Kleijn
Faculteit der Sociale Wetenschappen
kleijnrde@fsw.leidenuniv.nl | +31 71 527 3915
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Simon Marshall
Science
s.c.marshall@liacs.leidenuniv.nl | +31 71 527 2727
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Xaver Funk
Faculteit der Sociale Wetenschappen
s.x.funk@fsw.leidenuniv.nl | +31 71 527 2727
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Hanneke Leegwater
Science
h.leegwater@lacdr.leidenuniv.nl | +31 71 527 6274