454 search results for “genome organization” in the Public website
-
Mapping of bacterial genomes to combat infectious diseases
Mapping of bacterial genomes to combat infectious diseases
-
Barbara Gravendeel
Science
b.gravendeel@umail.leidenuniv.nl | +31 71 527 2727
-
Hanneke Leegwater
Science
h.leegwater@lacdr.leidenuniv.nl | +31 71 527 6274
-
1st Leiden Centre for Interdisciplinary Genome Research meeting
The 1st CIGR meeting was held on March 30, 2021, with talks by representatives of all participating groups.
-
Modulation of Stratum Corneum Lipid Composition and Organization of Human Skin Equivalents by Specific Medium Supplements
Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…
-
COMPOSING FOR ORGAN AND ELECTRONICS: SPACES AND PRACTICES
My research focusses on site-specific compositional and performance practices of music for organ and electronics and their musical-spatial values.
-
The Challenge of Enforcing Rule of Law in International Organizations
Growing public backlash against international organizations (IOs) and attacks of national political elites on the rule of law increasingly challenge governance by IOs.
-
Femke Reidsma
Faculteit Archeologie
f.h.reidsma@arch.leidenuniv.nl | +31 71 527 1680
-
Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
- Diplomacy in the Intergovernmental Organizations
-
Future of Multilateralism: Global Cooperation and International Organizations
The Future of Multilateralism addresses current challenges and future perspectives of international and regional organizations. It aims to uncover how stable the foundations of global cooperation really are, particularly in the light of the latest unilateral and protectionist practices of international…
-
Jaap Reijling
Faculty Governance and Global Affairs
j.reijling@fgga.leidenuniv.nl | +31 70 800 9400
-
Regenerative medicine: curing patients by regenerating organs, tissue and cells
Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…
-
Resolving rapid radiations
What are the phylogenetic relationships among the members of speciation bursts?
-
Who are leading? Explaining leadership behaviour in public organizations
This article explores how employees use leadership behaviours and how characteristics of the organizational context affect their engagement in leadership.
-
Sources of Meaning among organized non-religious ‘secular’ persons
Recently, studies have shown the similarities and differences in sources of meaning between religionists, ‘nones’ and atheists (see several studies of Schnell and others). The present study that will be conducted in three European countries tries to clarify the relationship between meaning giving and…
-
Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
-
Topology of polymer chains under nanoscale confinement: insights into genome folding
This month, a paper was published in Nanoscale by scientists from Dr. Alireza Mashaghi group at the Systems Biomedicine and Pharmacology Division in collaboration with the group of Dr. Sander Tans from TU Delft/AMOLF. In this paper, the authors studied how nanoscale spatial confinement affects the fold…
-
Unraveling Determinants of Inclusive Leadership in Public Organizations
This article aims to explore the determinants of inclusive leadership. This type of leadership is valued for social equity and fairness.
-
Evolutionary traps – Balanced lethal systems
How do balanced lethal systems originate and persist in nature?
-
The promise of organization. Political associations, 1820-1890, debate and practice
The central theme of the NWO-project ‘The Promise of Organization’ is the evolution of political organization during the 19th century. We focus on the enthusiasm, arguments and concrete activities of the organizers as well as the criticism offered by opponents of modern political organization.
-
Cryptic species discovery
Do understudied animals contain hidden species?
-
Negative About Failing Service Delivery by Public Than Private Organizations?
Petra van der Bekerom, Joris van der Voet, and Johan Christensen, three assistant professors at Leiden University, conducted a large-scale survey experiment about whether citizens are more negative about failing service delivery than private organizations.
-
Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
-
In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
-
Understanding the physical properties that affect the lipid organization in the skin barrier
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
-
Sarita Koendjbiharie
Faculty of Humanities
s.r.koendjbiharie@hum.leidenuniv.nl | +31 70 800 9535
-
behavior of skin lipid mixtures: the effect of cholesterol on lipid organization
The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).
-
Beyond Empires: Global, Self-Organizing, Cross-Imperial Networks, 1500-1800
Beyond Empires explores the complexity of empire building from the point of view of self-organized networks, rather than from the point of view of the central state.
-
Scalable organic solvent free supercritical fluid spray drying process for producing dry protein formulations
In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.
-
energy electron transmission through layered materials and chiral organic films
In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…
-
investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
-
debate: citizens’ perceptions of meritocracy in public and private organizations
Public management scholars have long debated public and private sector differences. However, the generalizability of empirical results has been limited due to the shortage of cross-national studies.
-
The monastery rules : buddhist monastic organization in pre-modern Tibet
This study discusses the position of the monasteries in pre-1950s Tibetan societies and how that position was informed by Buddhist monastic ideology.
-
A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
-
Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
-
The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
-
Restoring and constructing organs
Physicians and researchers of the Leiden University Medical Center (LUMC) and Leiden University are working on therapies for restoring damaged organs such as hearts and kidneys. They are even trying to construct tailor-made organs. Read more on this topic in the new science dossier on Vascular and Regenerative…
-
Willem Meilink
Science
w.r.m.meilink@biology.leidenuniv.nl | +31 71 527 4882
-
Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
-
The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame
-
Ton Koopman
Faculty of Humanities
a.g.m.koopman@hum.leidenuniv.nl | +31 71 527 1480
-
Michiel Veldhuis
Science
m.p.veldhuis@cml.leidenuniv.nl | +31 71 527 1494
-
Dirk-Jan Kok
Science
d.d.kok@cml.leidenuniv.nl | +31 71 527 2727
-
Coarticulation and polyphonic expression in the performance of piano and organ music
Performances of solo keyboard repertoire can sound more or less polyphonic depending on the performer’s use of divergence in expression.
-
This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
-
Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
-
Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
-
PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
-
Mosaic-Craftsmen and Workshop-organization in the Provinces of Arabia and Palestina during Late-Antiquity
This research focuses on figurative Byzantine mosaic-floors that have been excavated in the geographical area of the ancient provinces of Palestina and Arabia (current Israel, PA and Jordan) dating to the Late 5th, 6th and early 7th centuries C.E.