2,597 search results for “design” in the Public website
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Solving problems in your head and in the world
Until recently, the role of external information processing in intelligence has rarely been investigated quantitatively or experimentally. A group of researchers from Erasmus University Rotterdam, Leiden University, GGZ Rivierduinen, and University of Edinburgh measured in a new way how and when people…
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EQUALITY - Efficient QUantum ALgorithms for IndusTrY
Born in Europe roughly 100 years ago, quantum physics brought forth a veritable technological revolution through semiconductors, lasers, fibre optics, and many other technologies that are today ubiquitous in our lives. Now, during the second quantum revolution, Europe can take the lead once more in…
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New sports and exam centre
Leiden University began the construction of a new sports and examination center in collaboration with the construction and design firm Binx Smartility. The current sports and examination center no longer meets sustainability requirements and is also becoming too cramped.
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Metabolomics Facility
The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…
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A systematic review of current cybersecurity training methods
This article presents a systematic review aiming to provide a comprehensive overview of cybersecurity training methods and assess their effectiveness.
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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A micro-trial study to investigate the effectiveness of public speaking treatments in children
Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?
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Primitivism and architectural theory
Subproject of
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Antique Dealing and Creative Reuse in Cairo and Damascus 1850-1890: Intercultural Engagements with Architecture and Craft in the Age of Travel
This beautifully illustrated volume investigates the social life of objects moving between the Middle East and the West, revealing the range of agencies and subjectivities involved in their trade and reuse.
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Dimensions of student participation: participatory action research in a teacher education context
This thesis investigated the extent to which participation of school students in decision-making processes can be achieved, including through participatory action research (PAR) in teacher education.
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Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists
Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)
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Analogy, Technical Reason, and Living Beings: The Role of Analogy in Representing Kant's Concept of Naturzweck
This dissertation concerns the role of analogy in Kant’s “Critique of the Teleological Power of Judgment”, especially the role of analogy for the formation of the concept of a natural end (Naturzweck). A ‘natural end’ is a ‘regulative concept’ of the reflective power of judgment, that is, a heuristic…
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Novel approaches for direct exoplanet imaging: theory, simulations and experiments
The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.
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Projects
Research projects
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Got a friend in me?
Mapping the neural mechanisms underlying social motivations of adolescents and adults
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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On the origin of patterning in movable Latin type : Renaissance standardisation, systematisation, and unitisation of textura and roman type
This PhD-research is conducted to test the hypothesis that Gutenberg and consorts developed a standardised and even unitised system for the production of textura type, and that this system was extrapolated for the production of roman type in Renaissance Italy.
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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The E-Primer
The updated E-Primer expands its proven combination of simple explanations, interesting tutorials and fun exercises, and makes even the novice student quickly confident to create their dream experiment in E-Prime 3. E-Prime is the leading software suite by Psychology Software Tools for designing…
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About
The Centre for Indigenous America Studies (CIAS) at Leiden University is designed to coordinate and promote the teaching and research of Indigenous languages, literatures, cultures and cultural heritage. Our aim is to contribute to an increased acknowledgement, recognition and understanding of Indigenous…
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Laser-generated toroidal helium plasmas
This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.
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Grave Reminders
Comparing Mycenaean tomb building with labour and memory
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‘Ūd Taqsīm as a Model of Pre-Composition
In this research project Nizar Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.
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Appreci8: working on youngsters’ perspectives together
How do young people pursue their interests in and across multiple contexts while participating in tailor-made programs in vocational education and training (VET) and social enterprises to regain perspective in school and work?
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‘Ūd Taqsīm as a Model of Pre-Composition
In this research project Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).
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Algorithms and Software Technology
The Algorithms and Software Technology (AST) research programme performs fundamental research in the areas of algorithm design and analysis.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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From closed museum spaces to inclusive cultural meeting points
As museums face more scrutiny and are being demanded to decolonize, there are opportunities for Dominican museums to adopt a critical perspective and turn their collections and exhibitions into connections to our cultural past, present, and future.
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Quantum computation with Majorana zero modes in superconducting circuits
Promotor: C.W.J. Beenakker, Co-Promotor: A.R. Akhmerov
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Understanding deep meta-learning
The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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DAMIOSO - data mining on high volume simulation output
Modern computer-aided simulation tools used by various industries produce gigabytes of data. But currently, they take days and even up to weeks of computation effort. To make the best use of all these data, the DAMIOSO project focuses on developing algorithms and tools for managing, mining, and optimizing…
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Squaramide-based supramolecular polymers
Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.
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Quantum Information Science & Technology (MSc)
Quantum Information Science & Technology (QIST) encompasses the understanding, design, construction and investigation of quantum information processing systems, such as quantum computers, quantum communication networks, and quantum sensors.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Alverata, a present-day, European typeface with roots in the middle ages
The subject of this thesis is Alverata, a twenty-first-century typeface whose design was inspired by the shapes of Romanesque capitals such as those found in inscriptions of the eleventh and twelfth centuries.
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Graphene at fluidic interfaces
In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…
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Reading Arabic: legibility studies for the Arabic script
What is the cost of visual complexity? This dissertation sets out to determine the effect of the complexity of word formation on the legibility of Arabic and the role that vocalization plays in reading.
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UBC Europe – University-Business Cooperation in Europe
To goal of this project is to get a deeper, more comprehensive and up to date understanding of the state of University-Business Cooperations (UBC) in Europe, from the perspective of both the Higher Education Institutions and the business sector.
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Courses
Curious what Designing Your Life courses we offer at Leiden University? Take a look below!
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Key publications
Key publications of the Computational Drug Discovery group
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Resources and Energy
How do technological systems impact the environment? And can they be designed in a more sustainable way? The Resources and Energy research program studies the importance of resources and energy for our society and aims to guide the shift towards a sustainable circular economy.
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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Bridging the gap between macro and micro
The aim of this research was to develop an effective, generative, and practical approach to enhance students’ structure-property reasoning (SPR).