2,010 search results for “cancer drug resistance” in the Public website
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Workshops & Demo's
During the Leiden Science Family Day, you can take part in various workshops. You can also watch various demonstrations. Where will you go?
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Bioprinting human tissues for drug testing
Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…
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Adam Cohen receives Dr. Saal van Zwanenberg Honorary Prize
Professor of Clinical Pharmacology Adam Cohen from Leiden University received the prestigious Dr. Saal van Zwanenberg Honorary Prize on 12 November. The prize honours a scientist who has distinguished themselves in the field of research that has directly or indirectly led to the development of new medicines…
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Science for Society
By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.
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Drug Delivery to the Brain
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB
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Psychology student starts crowdfunding for cancer PhD research
'We believe that developing a protocol to help people fight cancer is extremely valuable, given that cancer is such a prevalent and devastating disease. If you believe so too, you can support us in realising this mission.' Master's student in Psychology Saskia Heijnen starts crowdfunding to make her…
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A much-needed new class of antibiotics
Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…
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‘How can we translate the language of cells into cancer therapies?’
On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…
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Sylvestre Bonnet
Science
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Wetenschappers ontdekken hoe darmbacterie resistent wordt
Een minuscuul cirkelvormig stukje DNA zorgt ervoor dat de darmbacterie Clostridioides difficile resistent raakt tegen een veelgebruikt antibioticum. Dat ontdekten wetenschappers van het Leids Universitair Medisch Centrum (LUMC) nadat artsen hen attendeerden op een patiënt met een moeilijk behandelbare…
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Research
The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology, and the Metabolomics and Analytics Centre.
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Child Cancer Fund subsidises statistical research
Marta Fiocco, professor in the Mathematical Institute, has received a grant for analysing data on chemotherapy in children suffering from leukaemia. The work involves developing and applying new statistical methods that will help determining the optimal dose of chemotherapy.
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Bioactive Molecules in Animal Sciences
Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Key publications
Key publications of the Cancer Drug Target Discovery group
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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the role of Dutch Intelligence Services (AIVD) in the fight against drug trafficking
Minister Grapperhaus wants to use intelligence services in the investigation of drug crime. There are many doubts about this wish in the intelligence world. Paul Abels, Professor by Special Appointment Governance of Intelligence and Security Services at the Institute of Security and Global Affairs (ISGA),…
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Protease-Responsive Targeted Delivery of Chemotherapeutics Holds Great Promise for the Treatment of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…
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Light relief
How can new compounds relieve cancer patients of severe side effects?
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Research
An overview of the research at the Biologics Formulation group
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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New measuring method facilitates drug research
Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.
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Frederic Lens
Science
f.p.lens@biology.leidenuniv.nl | +31 71 527 2727
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Marcellus Ubbink
Science
m.ubbink@chem.leidenuniv.nl | +31 71 527 4628
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Novel Chemical Modalities
The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
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CAM-PaC
The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Remembering Leiden-Indonesian resistance fighter Irawan Soejono
Large numbers of Indonesians were active members of the resistance during the Second World War. One of them was Irawan Soejono, a student at Leiden University. He was shot dead on Boommarkt, during a raid on 13 January 1945. Seventy-five years later he was remembered in a small ceremony in the very…
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References to the Steel Industry in a Definitive GGD Report on Lung Cancer in the Dutch IJmond Region
Arco Timmermans is Professor by special appointment Public Affairs at the Institute of Public Administration. On Dutch television programme 'EenVandaag', he discussed the remarkable changes that have been made in a report on lung cancer in and around the Dutch city of Beverwijk that was presented by…
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Advanced Pre-clinical Evaluation of the Guanidino Lipoglycopeptides: A Novel Family of Glycopeptide Antibiotics with Best-in-Class Potential
Can we make a better vancomycin?
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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NMR Facility
Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
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Knowledge of DNA repair in the fight against tumour cells
What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.
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Leiden University and LUMC join Netherlands Centre for One Health
Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.
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Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
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MUS writes biography of The Hague resistance heroine
Professor Wim Willems of the Centre for Modern Urban Studies (MUS), together with Anne van Mourik, is researching the life of Ru Paré, the woman who saved 52 Jewish children during World War II.
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Light-activatable ruthenium-based anticancer prodrugs
Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?