1,522 search results for “high throughput screening and microscopy” in the Public website
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Development of novel analytical technologies for metabolomics and systems pharmacology
We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.
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Smartmix: A new generation of efficient biomedical research
Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?
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Jaap Reijling
Faculty Governance and Global Affairs
j.reijling@fgga.leidenuniv.nl | +31 70 800 9400
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Simon Portegies Zwart
Science
spz@strw.leidenuniv.nl | +31 71 527 8429
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Towards nano-MRI
By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Core Facilities
Core Facilities are shared resources that provide access to instruments, technologies and services to researchers across the Institute of Biology. They are staffed by scientists with vast experience in their field, ensuring that all researchers can count not only on the latest available technology…
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Single-molecule microscopy in zebrafish embryos
PhD defence
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Huub de Groot
Science
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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Research
Research at the BIOSYN group is comprised of the following research themes:
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Personalized Medicine
Getting personal
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Surprising similarity between stripy black holes and high-temperature superconductors
We don’t understand how some materials become superconducting at relatively high temperatures. Leiden physicists have now found a surprising connection with auxiliary black holes. It enables us to use our knowledge of black holes on the mystery of high-temperature superconductivity. Publication in Nature…
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Strikes the result of high inflation
Employees are laying down their work in various sectors, such as regional public transportation and Dutch postal service PostNL. Inflation appears to be increasing dissatisfaction about working conditions, thinks Barend Barentsen, Professor in Labour Law at Leiden University. ‘It's the final straw.’
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Resolution of electron microscope greatly improved
The use of a new type of detector has generated a strong improvement in the resolution of electron microscopes. The 'low-energy electron microscope' (LEEM) can now be used for research on the thinnest possible materials. The tests with the detector represent the first result of the ESCHER project.
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Paradox in superconductivity at high temperature
Nature publishes an article on a paradoxical discovery in superconductivity. Physicists are searching for superconductivity at high temperatures so that less cooling is needed in for example MRI machines. News & Views article by Prof. Jan Zaanen in the same issue of August 19th.
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Aspects of cosmic acceleration
The focus of the dissertation
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Surface and Interface Science
The nanoscale structure of a catalyst under reaction conditions determines its activity, selectivity, and stability. For the production of sustainable energy and materials, new catalysts are needed. By understanding the structure-activity relationships of catalysts under reaction conditions, insight…
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
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Quantum Matter and Optics
Research groups in the Quantum Matter & Optics programme investigate electronic properties of matter and light-matter interactions with emphasis on quantum information.
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Growth and development of actinomycetes
We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.
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Insulating phenomenon in superconductor
Leiden physicist Milan Allan and his group have discovered an apparent paradox within a material that has zero electrical resistance. They measured trapped charges, while charges should in theory keep flowing in the absence of resistance. The discovery could provide a missing piece of one of the big…
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Optoplasmonic detection of single particles and molecules in motion
Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.
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A physicochemical study of Medieval and Post-Medieval ceramics from the Aegean
Archaeometric analysis of glazed pottery assemblages from the Early Byzantine to the Early Modern periods in the Aegean.
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Insights into microtubule catastrophes: the effect of end-binding proteins and force
For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.
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1st Leiden Centre for Interdisciplinary Genome Research meeting
The 1st CIGR meeting was held on March 30, 2021, with talks by representatives of all participating groups.
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Sense Jan van der Molen Lab - Physics of Quantum Materials
In our lab, we investigate the physics and material properties of low-dimensional systems.
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Yao Yuan speaks at conference in Rome
On 28 October 2022, Yao Yuan spoke at the conference in Rome on 'Understanding national security concerns in light of FDI screening', jointly organised by Università Telematica internazionale UNINETTUNO and Uppsala University.
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HEPGAME
HEPGAME is a research project that combines the world’s fastest computer algebra system for High Energy Physics equations, FORM, with insights from artificial intelligence. The name combines High Energy Physics and Games.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Physicist Michel Orrit new member KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit.
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Barend Mons appointed Chair of European Commission’s High Level Expert Group
Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Scanning mutagenesis in a yeast system delineates the role of the NPxxY(x)(5,6)F motif and helix 8 of the adenosine A(2B) receptor in G protein
Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)
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Insights from scanning tunneling microscopy experiments into correlated electron systems
PhD defence
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
PhD defence
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Leiden Physics hosts 2016 NEVAC day
The Leiden Institute of Physics hosted the annual conference of the Dutch Vacuum Society (NEVAC). Experts in the field of vacuum experiments talked about their research. The 2016 NEVAC Prize was awarded to PhD student Martijn Vos from the TU Eindhoven.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Hooray! This extremely sensitive microscope survived its relocation
Moving an electron microscope of 2000 kg is a delicate challenge. The highly sensitive instrument needed to be moved to a new measurement hall, but even a tiny bump could damage it. After a few nerve-racking weeks of preparing the move and reinstalment, the researchers finally have a verdict: the instrument…
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What are the ingredients of high performing district teams?
Since the decentralizations in the social domain in 2015, nearly all Dutch municipalities use district teams to organize care. However, the management, organization and composition of these district teams vary considerably between municipalities: each municipality tries to reinvent the wheel by itself.…
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Evolution of bacterial movement revealed
An international team with researchers from Leiden revealed how a bacterium repurposed an internal system to control its movements. Movement control is very important in host invasion, which can lead to disease. Publication on 27 April in Nature Communications.
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Slovenian and Czech high school students visit Leiden University
Sixty-four high school students from Slovenia, Czech Republic and The Netherlands have visited Leiden University in the week of 7-11 November, as part of the Talent Education Project. They split in eight groups, of which some went to the science faculty to conduct research projects.
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Thomas Hankemeier
Science
hankemeier@lacdr.leidenuniv.nl | +31 71 527 4226
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Quantum Matter and Optics
The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.