410 search results for “dna” in the Public website
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NWO ECHO grant for research on fickle RNA production
Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Control of replication associated DNA damage responses by Mismatch Repair
PhD defence
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Characterization of DNA-replication proteins and their molecular mechanisms
PhD defence
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PhD Theses
A full overview of MacBio PhD Theses.
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Fungal Chitosans from Fermentation Mycelia for Plant Biostimulants (FunChi)
Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Overcoming the Debye screening length with radiofrequency-operated graphene biosensors
Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Bacterial Chromatin
The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…
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The mechanism of Agrobacterium-mediated transformation of eukaryotic cells
We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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2 PhD Candidates to study transcription factor binding at the single-molecule level
Science, Leiden Institute of Physics (LION)
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Chromatin dynamics in single genes
John van Noort
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Centre for Interdisciplinary Genome Research
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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PhD Theses
A full overview of MCBIM PhD theses.
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Participants
The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).
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Statistics when your models are wrong
Peter Grunwald
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The prehistoric origin and spread of the Indo-Iranian languages
A linguistic test of hypotheses rooted in genetics and archaeology.
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Bio-inspired Computing
We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.
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Tracing human mobility across the Caribbean
What are the patterns and processes of human mobility in the pre-colonial circum-Caribbean as revealed by burial populations and what are the underlying motives and socio-cultural principles on both micro- and macro-scales?
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Next444 Roundtable Report
How do we make tomorrow more sustainable, equitable, fair, and just? On the evening of 5 February scholars gathered in the conference room of Grand Café The Burcht to discuss this grand question at the Next444 Roundtable. Organized by the Young Academy Leiden as one of the final events of the Leiden…
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Regulation of enzyme production in fungal cell factories
Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.
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Plant Sciences
The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…
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Biodiversity
Biodiversity is under pressure worldwide, but is essential for our health, food security and well-being. What is the influence of human actions on ecosystems? Can we provide biodiversity-inclusive solutions for our key societal challenges? These questions are central to the Biodiversity research the…
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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CRISPR Cas-induced targeted mutagenesis with Agrobacterium mediated protein delivery
The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.
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Mathematical modeling of cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Archaeological Sciences
The Department of Archaeological Sciences seeks to achieve the highest standards of excellence in science-driven education and archaeological research across the globe and across all periods.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Paul Hooykaas
Science
p.j.j.hooykaas@biology.leidenuniv.nl | +31 71 527 4933
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Identification and characterization of novel factors in the DNA damage response
PhD defence
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Mechanisms underlying mutational outcomes of DNA double-strand break repair
PhD defence
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Publications
Relevant publications of the CIGR participants.
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Diversity and inclusion at the Faculty of Social and Behavioural Sciences
Within the Faculty of Social and Behavioural Sciences (FSW), D&I translates as the diversity of backgrounds, perspectives, and identities among both students and staff.
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Awards and Grants 2017
An overview of awards and prizes granted to our staff and students in 2017, as well as special appointments and royal distinctions.
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Rural Riches
The bottom-up development of post-Roman northwestern Europe
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Internationalisation
As a university we stand with both feet firmly in the world. Internationalisation is in Leiden’s DNA: from the very foundation of our university, the ideal of the free academy has always attracted researchers and students from across the whole world, and that will continue.
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Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?