553 search results for “computer ahmed drug design” in the Staff website
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Versatile antiviral proteins discovered with supercomputer
A single tiny molecule that can destroy flu, corona, HIV and Zika viruses? Yes, it really does exist. Biophysicist Niek van Hilten, who will receive his doctorate on 14 September, contributed to this discovery.
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Better treatment of skin diseases thanks to NWA grant of 11.7 million euros
Patients with skin diseases such as eczema and psoriasis, sometimes spend a lifetime searching for the right medication. To help these patients faster and better, scientists across the country are joining forces. The Next Generation ImmunoDermatology (NGID) project, with LACDR professor Robert Rissmann…
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3 October University: ‘Artificial intelligence is like young people and sex’
‘Everyone’s talking about it, everyone thinks everyone else is doing it, but the reality is disappointing,’ says biochemist Gerard van Westen in his 3 October University lecture in the Van der Werfpark. In the full marquee, he gets a laugh with this suggestion that artificial intelligence is comparable…
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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Awarded research project Next Generation ImmunoDermatology: Towards Biomarker-driven Dermatology practice in the Netherlands
The Dutch Research Council (NWO) has, within the framework of Research along Routes by Consortia (NWA-ORC), awarded the research project Next Generation Immuno-Dermatology (NGID) with a prestigious grant of 11.7 MEuro. NGID is a nationwide, large-scale project to unravel novel biomarkers for six different…
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Four NWO Open Competition grants for Leiden researchers
Four researchers from Leiden University have been awarded NWO Open Competition grants in the Science domain. This is for research into subjects such as immune cells in tumours, antibiotic resistance and magnetic semiconductors.
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Let's Play Quantum Games
Lecture
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ERC-grant for Sebastian Pomplun to cure disease by controlling gene expression with synthetic transcription factors
Sebastian Pomplun receives an ERC starting grant of 1.85 million Euros in five years. He wants to develop synthetic transcription factors that can enter cells and activate or deactivate specific genes. For example to disrupt cancer-related processes or to trigger the production of an important missing…
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Interview with Jaap van den Herik by BNVKI
Recently, Jaap van den Herik, professor emeritus Law and IT, was interviewed by the BNVKI (Benelux Association for Artificial Intelligence).
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Wanda van der Stel - ALTEX Prize Winner 2022
The members of the Board of ALTEX Edition, the ALTEX Editorial Board and ALTEX Editorial Office elect the winner of the annual award out of all main articles published in the previous year; articles including members of the Board of ALTEX Edition or ALTEX Editorial Office as first authors are excluded.…
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Podcast: A changing view on psychedelics
We talk with Michiel van Elk, about his research into mapping what effects psychedelics have on the human brain and what this means for the possible clinical application of these drugs. The cognitive psychologist shares his findings with a sober view, bringing critics and fanatics closer together for…
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
PhD defence
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Exchange and inspiration at the Education Showcase
On Friday 20 May, from 1 p.m. to 6 p.m., approximately sixty lecturers met at the Faculty Club for the 2022 Education Showcase.
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Teaching Fair of the Faculty of Humanities puts teachers in the spotlight. You are invited!
Share experiences, gain inspiration or catch up with colleagues: you can do all of these at the Teaching Fair on 30 June. Co-organiser Anna Benjamins explains what the afternoon has in store.
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Vidi grant for Angus Mol: ‘Historical games are like time machines’
How do games help shape our perception of the past? Associate Professor Angus Mol receives a Vidi grant to answer this question.
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How to make an old antibiotic a hundred times more potent
Nathaniel Martin, Professor of Biological chemistry, wondered what would happen if you take an antibiotic that has been known for 70 years and try to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant…
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Dies Natalis all about innovating and connecting
‘We could share our knowledge more with others and apply it more widely,’ said Annetje Ottow, President of the Executive Board, while presenting the new Strategic Plan on the University’s 447th Dies Natalis. The new Strategic Plan therefore focuses on innovating and connecting, among disciplines and…
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ULLA workshop – summer school - courses
We are proud partner of the ULLA. It is the European University Consortium for Pharmaceutical Sciences in which LACDR participates for already 30 years. We have the honor to host the ULLA workshop in 2023 and the ULLA summer school in 2024.
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Prof Dr Joke Bouwstra receives the “ Dr Saal van Zwanenberg Ereprijs”
Prof Dr Joke Bouwstra will receive the “ Dr Saal van Zwanenberg Ereprijs” from the “Koninklijke Hollandse Maatschappij der Wetenschappen” on November 14 in Haarlem. Joke is awarded for her innovative contributions to the field of skin delivery science and technology. She shares the price with prof…
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Tamara Danilyuk wins the EUROTOX 2023 Early Career Award
I am thrilled to share the exciting news of being honored with the 2023 Early Career Award at the EUROTOX conference held in Ljubljana, Slovenia. This recognition, presented by ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals) and dedicated to the memory of Dr. Christa Hennes, holds…
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Interview Micha Drukker
Micha Drukker
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Nature Communications paper on therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.
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Interview
Sabine de Winter
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(University of Cambridge) and Mari Lending (Oslo School of Architecture and Design)
Alumni event, Lecture
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Erasmus+ grant for 13 exchange projects
Thirteen Leiden University exchange projects have been awarded an Erasmus+ International Credit Mobility grant. The total award of around 450,000 euros will enable 103 students and staff to go on an exchange.
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Psychologists participate in high-tech biomarker research in health care
Next generation immunodermatology (NGID) is a nationwide, large-scale project, funded by a large grant of the Dutch NWO to unravel novel biomarkers for six different skin diseases. These biomarkers will drive a high-tech, patient-centric approach in clinical practice. Health psychologist Sylvia van…
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KiKa grant for mathematician: how statistics helps fight bone cancer
Using mathematics to help children with bone cancer. It sounds a little strange, but for statistician Marta Fiocco, it's just her job. She gets a substantial grant from KiKa for it. With that money, she is going to study the effect of chemotherapy adjustments.
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Proof of Concept grants for four Leiden researchers
Four Leiden researchers have been awarded Proof of Concept grants by the ERC. These grants, each worth 150,000 euros, help researchers translate the findings of previous ERC projects into innovative practical applications.
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This is the library you did not know you had been looking for
2,240 plant extracts from 1,299 different plant species of Dutch origin. That’s the collection of the Dutch Extract Library, which has recently been transferred to the Institute of Biology Leiden. To plant biologist and contact person for this library Pingtao Ding this is a true treasury. ‘To bring…
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Professor calls for more focus on brain impairment in offenders
Maaike Kempes believes more attention should be paid to non-congenital brain injuries in suspects. This may partly explain their criminal behaviour.
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EUFEPS congres
EUFEPS Women in Pharmaceutical Sciences Award for Jara Bouma
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Erik Danen new Dean of the Graduate School of Science
The Graduate School of Science starts 2024 with a new Dean. The Faculty Council appointed Erik Danen for the coming four years. He succeeds Eric Eliel, who has held the position since May 2020.
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Strength In Numbers
Inaugural lecture
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Can Parkinson's be stopped by unravelling protein fibres? Anne Wentink finds out with a Vidi grant from NWO
In brain diseases such as Parkinson's and Alzheimer's, proteins clump together to form fibres. ‘Chaperone proteins’ unravel those fibres, but in the test tube biochemist Anne Wentink saw that this can also cause new problems. She is going to find out what happens inside cells to determine what a drug…
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Looking at the person beyond the blood clot
How can we improve the treatment of thrombosis, reduce the disease’s impact and spend less money while we’re at it? This is what Erik Klok, Professor of Internal Medicine and an internist, is researching. He will discuss it in depth in his inaugural lecture on 10 March.
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Improving nature’s antibiotic
'What nature made isn’t necessarily an optimized medicine to use in the human body,’ says Professor of Biological Chemistry Nathaniel Martin. That’s why a group of Leiden researchers is making a chemistry-based improved version of the frequently used antibiotic vancomycin. They received an NWO NACTAR…
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Study associations sign covenant: limit your alcohol consumption and look after each other
Opting more often for mocktails or soft drinks rather than beer or wine, talking to others about their drinking and pointing out the ban on drugs. Leiden University’s new covenant on alcohol and drugs for study associations encourages providing more alcohol-free alternatives.
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Superselective bonds light up
Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researchers first caught this phenomenon using spheres or colloids, and published…
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Seven Comenius grants for Leiden lecturers
Eleven lecturers from Leiden University have been awarded Comenius grants that will allow them to work with their teams on an innovation project within their own teaching. They have been awarded three grants of 100,000 euros within the Senior Fellows programme and four grants of 50,000 euros within…
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Learning Analytics: Using Learning Outcomes for a Personalized Brightspace experience
Lunchbyte
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On this public day on psychedelics, researchers transcend the media hype
Never before has so much research been carried out on the therapeutic effect of psychedelic drugs. Researchers at the LIBC Public Day are happy about the effect the drugs can have on depression, anxiety and PTSS, but at the same time they have some doubts. ‘The hype is bound to crash before long.’
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Sibel Bahtiri is one of the new Faces of Science: ‘I want to show how we’re finding alternatives to animal testing’
PhD candidate Sibel Bahtiri is one of the new Faces of Science. In videos and blogs, she will show what life is like as a young researcher.
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How Europe will be better prepared for the next pandemic
The European PANVIPREP research project started at the Leiden University Medical Center on 11 March. The participants are virologists, biochemists and pharmacists from 14 European countries. Their mission is to develop antiviral drugs to protect Europe during pandemics. At least two such antivirals…
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Warfare: technology and ethics - a reading list
While the United States continues to carry out drone strikes, and China conducts large-scale cyber and information operations, Ukrainian and Russian soldiers live in trenches, and NATO sends tanks to the Donbas front to force a breakthrough. Has war changed dramatically in recent decades as a result…
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Carlijn Lems wins the Suzanne Hovinga Award 2020-2021
During the LACDR Fall Symposium the Suzanne Hovinga Award for ‘best master thesis’ was awarded to Carlijn Lems for her master thesis entitled ‘Elucidating the crosstalk between epithelial-to-mesenchymal transition and Programmed Death-Ligand 1: validation and extension of a computational model’. Carlijn…
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The future of artificial intelligence
From self-driving cars to innovative drug development, artificial intelligence (AI) is going to fundamentally change our lives in a variety of ways.
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Niek Kijk in de Vegte wins the Suzanne Hovinga Award 2023
During the LACDR Fall Symposium, Niek Kijk in de Vegte received the annual Suzanne Hovinga Award for the best master thesis. Niek performed his RP1 research under the supervision of Dr. Natalia Ortiz Zacarias and Prof.dr. Laura Heitman in the Molecular Pharmacology group at the Division of Drug Discovery…
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LACDR Fall Symposium 2021
On Thursday the 9th of December the LACDR Fall Symposium 2021 took place. Although the plan was to organize this symposium physically, unfortunately this was not possible due to the corona measures and it became an online event.
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Towards translation of CNS pharmacokinetics from mice to men
PhD candidates Mohammed Saleh and Berfin Gülave (Division of Systems Pharmacology and Pharmacy) published their research paper on “Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice”.
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Douwe D. Breimer Research fund
Prof. dr. Douwe Breimer, emeritus Professor of Pharmacology, former Rector Magnificus and founder of LACDR has established a foundation to stimulate, support, and promote scientific meetings in the field of Pharmacology. Particularly those concerned with fundamental research and mathematical modelling…