569 search results for “dna” in the Public website
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Kevin Groen
Science
k.groen@cml.leidenuniv.nl | +31 71 527 6822
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Sam Boerlijst
Science
s.p.boerlijst@cml.leidenuniv.nl | +31 71 527 2727
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Proteins and DNA loops: Science-Groot grant for Remus Dame
How do our cells keep DNA stored away? To find out, biochemist Remus Dame received a 3 million euro Science-Groot grant. Leiden University will share the grant with TU Delft, VU Amsterdam and the Hubrecht Institute.
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Not wrapping but folding: Bacteria also organise their DNA (but they do it a bit differently)
Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…
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New method for extracting human DNA from archaeological objects yields success
An international team of researchers led by Leiden archaeology professor Marie Soressi and Leipzig senior geneticist Matthias Meyer has recovered the DNA of a woman belonging to an Ancient North Eurasian population from a 20,000-year-old pendant. This is the first time DNA analysis has been used to…
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Ancient DNA reveals impact of the “Beaker Phenomenon” on prehistoric Europeans
In the largest study of ancient DNA ever conducted, an international team of scientists has revealed the complex story behind one of the defining periods in European prehistory. The study is published this week in the journal Nature.
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Human-wildlife Interactions in the Western Terai of Nepal
Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.
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Ancient DNA study reveals large scale migrations into Bronze Age Britain
A major new study of ancient DNA has traced the movement of people into southern Britain during the Bronze Age. In the largest such analysis published to date, scientists examined the DNA of nearly 800 ancient individuals. Publication in Nature on December 22, 2021.
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innovative research presenting a new method for recovering ancient human DNA
Since the publication of the article in the interdisciplinary journal Nature, over 200 news outlets have showcased the pioneering research.
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DNA analysis of historical mosquitoes will help us understand malaria transmission
Researchers from Leiden University, McMaster University and Public Health Ontario are calling on colleagues to track down archival specimens of mosquitoes from museums and other collections and to examine them with modern methods. This will tell them more about malaria transmission.
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Executive Board column: Our institutes abroad are part of our international DNA
Ever since its foundation, Leiden University has turned its gaze outwards to other cultures, languages and forms of academic practice. It is only natural, therefore, that we as a university have four institutes abroad: the Royal Netherlands Institute of Southeast Asian and Caribbean Studies (KITLV-KNAW)…
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3 October University: from Russian DNA to drug-related violence
In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Jac Aarts
Faculteit Archeologie
j.m.m.j.g.aarts@arch.leidenuniv.nl | +31 71 527 2727
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Louie Krol
Science
l.krol@cml.leidenuniv.nl | +31 71 527 2727
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Mobility and exchange
Dynamics of material, social and ideological relationships in the pre-Columbian insular Caribbean
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Can we live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
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Biophysicists unravel exact folding of a single gene
The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.
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Resolving a bioindicator diatom species complex using genomic approaches for freshwater biomonitoring
This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;
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Two graphene layers lean in for a kiss
Leiden physicists and chemists have managed to bring two graphene layers so close together that an electric current spontaneously jumps across. In the future this could enable scientists to study the edges of graphene and use them for sequencing DNA with a precision beyond existing technologies. Publication…
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Systematics, Epidermal defense and Bioprospecting of Wild Orchids
This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.
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Macrophage activation and cholesterol accumulation in atherosclerosis development
Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck
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DNA from a cup of pond water can reveal a lot: Kat Stewart will find out with a Vidi grant from NWO
She has had the idea for seven years, but now environmental scientist and conservation biologist Kat Stewart finally gets to work on it. She has been awarded a Vidi grant by NWO to find out how DNA from water can be used to shed light on invasive species and their impact on native populations.
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DNA-Decorated soft nanostructures from the self-assembly of DNA amphiphiles
Lecture
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Unfolding the principles of genome folding and dynamics in bacteria
What are the principles of genome folding and dynamics in bacteria?
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Comparative ecology and genetics of sympatric wild cats in relation to human wildlife conflict in Bardia National Park, Nepal
What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…
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Fungi of the greening Arctic: compositional and functional shifts in response to climatic changes
Promotor: E.F. Smets Co-promotor: J. Geml
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Outreach
The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.
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Integrative taxonomy of araneomorph spiders: Breathing new life into an old science
Taxonomy as a science has accumulated data and knowledge for more than 250 years.
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spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort
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Chromatin organization & dynamics (Dr. Remus Dame)
Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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High fidelity DNA replication and repair
PhD defence
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Measuring water life
Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Fire use in human evolution: A genetic approach
Are traces of fire use detectable in ancient hominin genomes?
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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Chromatin organisation & dynamics
The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Break-through in the genetic modification of plants
A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…
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John van Noort appointed Professor in Biophysics
Leiden University has appointed John van Noort as Professor in Biophysics. He studies the way in which our DNA is folded and read out.
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.