2,264 search results for “drug safety” in the Public website
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Personalized drug repositioning using gene expression
PhD defence
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Key publications
Key publications of the Antiviral Pharmacology group.
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Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.
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Imaging functional brain connectivity: pharmacological modulation, aging and Alzheimer's disease
Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474, SCIENCE, 2017
The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…
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Exploration of the endocannabinoid system using metabolomics
To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.
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Amphiphilic miktoarm star copolymers
Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Matching medication to DNA leads to 30% fewer side effects
According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.
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Previous Winners
On this page you can learn more about the history of our Faculty Awards and view the previous winners.
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CIMPLO – Maintenance prediction for industries
Researchers of the Leiden Institute of Advanced Computer Science (LIACS) have started a 4 year project on developing a system that sends out automatic alerts when components from engines are showing first signs of fatigue.
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Nanomaterial safety for microbially-colonized hosts
PhD defence
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
PhD defence
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PhD student becomes headwind cycling champion: ‘Just put your chin over the handlebars and pound the pedals’
With a headwind of 80 kilometres per hour, pouring rain and freezing temperatures, Jurjun van der Velde cycles down the Oosterscheldekering. On his traditional Dutch bike with back pedal brake, he is the second PhD student from the faculty to win the title.
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Eduard Fosch Villaronga: 'Robots are mainly for the average person'
IT lawyer Eduard Fosch Villaronga wants to promote diversity and inclusiveness in AI research. And that's really important, because he has observed how artificial intelligence - from Twitter to walking robots - is prejudice in terms of race, gender and sexual orientation.
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Security Studies
Security is key to survival for any living organism: life is full of perils and threats, both physically, environmentally, and societally. Security challenges such as terrorism, natural disasters, and cybercrime rank among the most pressing issues of our time, affecting the security and safety of millions…
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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Covalent inhibitors of G protein-coupled receptors: the case of adenosine receptors
Supervisor: Xue Yang
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Unsafe products in e-commerce
European product safety law is one of the focal points of internal market legislation.
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Janssen COVID-19 vaccine approved for use in EU
The Janssen-Cilag International N.V COVID-19 vaccine has received authorization for emergency use by the European Medicines Agency (EMA) on March 11. The vaccine was developed with fundamental support from the Molecular Virology group of the Leiden University Medical Centre (LUMC).
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Medical Delta AI for Computational Life Sciences
The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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AiChemist project
The AiChemist project (https://aichemist.eu) coordinated by Helmholtz Munich is an Innovative Doctoral Training Network funded through the Marie Skłodowska-Curie Actions (MSCA-DN) within the EU Horizon Research Framework, to the sum of €3 million. It brings together leading experts in AI, chemoinformatics…
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Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Societal impact
Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Cheminformatics: Analyzing small-molecule activity data
While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Grants & Awards
Grants awarded to molecular physiology research
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Pharmacological resting-state fMRI in aging and dementia
How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?
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LED3 Lectures
The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…
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Reijer Passchier discusses the risks of artificial intelligence
Reijer Passchier, Assistant Professor of Constitutional and Administrative Law, recently published a statement entitled 'The AI Safety Summit at Bletchley Park Asked the Wrong Questions' in the International Journal of Social Quality.
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Podcast series introduces you to the BSc Security Studies
With this podcast series 'Introduction to Security Studies', you will get to know more about the bachelor's programme Security Studies at Leiden University in The Hague and life as a student in The Hague.
- GTGC lunch seminar: Santino Regilme on Global Drug Wars
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Application procedure
The application procedure is broken down into three parts.
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Researchers reveal how stem cells make decisions
Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…
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Discoverer of the Year bridges science and medicine
Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…
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Champion in headwind and predictions
It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).
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Is a cancer pill a matter of time?
A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.