This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that selectively target specific cell types, their systemic application often results in unwanted liver accumulation. The exact mechanisms for this general observation are still unclear.

In a project of INSOL Europe's Turnaround Wing, TRI Leiden is working on the design of Principles and Guidelines for Restructuring and Turnaround Professional. These Principles and Guidelines are designed for the out-of-court turnaround of a business in distress. This Report is the result of a study…

In the light of today’s major changes and challenges, the congress on November 22 will focus on Redesigning the Designer while also taking some of the examples of more-than-human knowledge experimented with within Neuhaus as a starting point for a new network.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

The aim of this study was to provide insight into how teachers in higher education can be supported in the design, implementation and evaluation of group assignments by developing a theoretical and evidence-based framework for the design of group assignments.

The authors systematically search and review relevant definitions of Security by Design (SbD) in comparison with Privacy by Design (PbD).

This thesis describes the design, characterization and application of dextran based crosslinked network.

The studies reported in this thesis were situated in the context of an innovation of Dutch secondary school biology curricula. As in any innovation, the practical knowledge of teachers determine the outcomes through the decisions they make while planning and teaching their lessons. The aim of the studies…

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotor: Prof.dr. T.H.W. Bäck

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Beginning teachers often experience difficulties making activating lessons. This study investigates how and if the practical teaching model can offer them a hand in learning to design lessons.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

In order to analyze the challenges linked to data use in the context of nexus governance, Giest & Mukherjee use a policy design lens and more specifically the perspective of organizational policy instruments to look at the Mediterranean region.

C-SIDe project involves a broad selection of associates in solving cybersecurity problems. Security of software systems has emerged as a critical need in our interconnected society. Companies developing software products look for Security-by-Design approaches accommodating security into their software…

This project is situated within the context of an innovation of the biology curriculum in Dutch secondary schools. The main purposes are (1) to clarify the relation between teachers’ practical knowledge and the decisions they make when planning and implementing their lessons and (2) to develop a professional…

How to contribute to a quantum leap of eco-industrial symbiosis in China?

How do we approach education that facilitates creative confidence for students that leads to innovative solutions to society’s present day and future sustainability challenges? This education research project tackles a sustainability dilemma faced by households in everyday life viz.

Research and design are becoming more and more important in international science education. In The Netherlands, two recently introduced subjects focus on research and design activities in the classroom: O&O (research and design) and NLT (nature, life and technology). This research aims to look at what…

Promotor: E.F.A. Deprettere, Co-Promotor: A.C.J. Kienhuis

Procedural administrative law in a constitutional comparative law perspective

Welcome and great to see you are interested in Designing Your Life education! Whether you are a student or educator, this website has everything you need to get started.

In 2021, the National Cyber Security Centre (NCSC) asked Leiden University to conduct a rapid review of best practices and possibilities for follow-up research on the integration of behavioral sciences in security by design methodologies and projects. This academic field is called security by behavioral…

This research intends to study the why, what, how and the possible outcome of internationalisation in higher education institutions of fine art and design.

In the first part of this thesis we study the geometry of folding patterns.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

The Lectorate Design at the KABK explores the research method of walking from a design perspective, and features the working process used by public space and landscape designers Krijn Christiaansen and Cathelijne Montens (KCCM) who teach field research in BA Interior Architecture and Furniture Design…

How is collaborative learning in teacher education designed and implemented? How do students experience those collaborative learning assignments? What aspects of the design and the implementation lead to which perceived learning outcomes?

Consumer societies are a global presence, and marketing practices have spread to all corners of the world. However, the loud and glaring performances of the big advertising companies and the hegemony of shopping malls makes us forget that there are many different markets, and many merchants who have…

Even a small quantum computer should be able to simulate exactly the properties and behaviour of new molecules. This would take chemistry to an entirely new level. Better solar panels, more powerful batteries, saving lots of energy in the chemical industry: the applications have the potential to transform…

The design process of new buildings is extremely complex due to strict requirements. Computer models are used to create the designs. Scientists from LIACS developed advanced algorithms that help their colleagues at Eindhoven University of Technology to optimise these models.

Do you sometimes find yourself sweating in the classroom while your students are really relaxed? Do you find yourself answering your own questions more often than your students? Are your students mainly concerned with getting a good grade while putting in minimum effort?

Turnaround Wing of INSOL Europe and Leiden Law School are working on the design of ‘guidelines for out-of-court turnaround professionals’. The project was approved by the Council of INSOL Europe at its 2014 conference in Istanbul and subsequently started in November 2014.

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This dissertation examines how Benedictine monks at the Abbey of Fécamp designed, produced, and read books over the course of the eleventh and twelfth centuries.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.