1,856 search results for “drug safety” in the Public website
-
Career preparation
Leiden University offers you several services related to career orientation and job application skills.
-
From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
-
market needs: new course for master’s students focuses on quality in drug development
Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…
-
Bioprinting human tissues for drug testing
Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…
-
NMR Facility
Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…
-
Oncode Accelerator launched: patients at the centre of innovative cancer drug development
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process.
-
Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
-
Teris van Beek
Dr. at the Department of organic chemistry, Wageningen University - the Nederlands
-
Industrial Pharmacy (MSc)
The master’s specialisation Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical industry.
-
Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
-
Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
-
De Witte et al publish in Nature Drug Discovery Reviews
Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange
-
Defeat by popular demand: public support and counterterrorism in three western democracies, 1963-1998
Acquiring and maintaining public support is frequently cited as an important requirement for governments fighting non-state actors. But how exactly can public support influence the course of counterterrorism campaigns and thereby contribute to an escalation or de-escalation of violence?
-
The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
-
Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
-
Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
-
GTGC lunch seminar: Santino Regilme on Global Drug Wars
On the 6th of March 2023, Santino Regilme presented his work-in-progress titled 'Global Drug Wars: Contested Normative Orders of Peace, Security, and Human Rights'. If the battle against illegal drugs is construed as a war, how is victory in such a war defined and constructed? If the oppositional…
-
Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
-
Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
-
Drug development: how can we make it more efficient?
It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…
-
KNAW advisory report on social safety in Dutch academia
At the beginning of July, a committee appointed by the Royal Netherlands Academy of Arts and Sciences (KNAW) presented its report 'Social Safety in Dutch Academia. From Paper to Practice', to the Dutch Minister of Education, Culture and Science. The committee was chaired by Professor Naomi Ellemers…
-
Jos Brosschot
Faculteit der Sociale Wetenschappen
brosschot@fsw.leidenuniv.nl | +31 71 527 3740
-
From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
-
Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
-
New project uses artificial intelligence in drug development
In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…
-
The Muslim Brotherhood in Europe
Scholars have long debated the intentions of the Muslim Brotherhood in the Middle East. Some claim the organization supports terrorism, while others believe it is a positive force for democratization.
-
Who Are They and Why Do They Go? The Radicalization and Preparatory Processes of Dutch Jihadist Foreign Fighters
How do European Muslim men and women become involved in a violent jihadist struggle abroad?
-
Conspiracy, legitimacy and violence
Can conspiracy constructions explain for hatred of the system? And if so, should conspiracy constructions be considered to be a risk in terms of national security?
-
Countering nerve pain caused by chemotherapy with new drug
Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…
-
Monitoring Cytoskeletal Conductance Variation for Sensing Cancer Drug Resistance
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…
-
Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?
-
Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
-
Safety Survey: NVIC students feel very safe in Cairo
The safety of students is a priority and hence an ever recurring issue at the NVIC. NVIC not only attaches great importance to the safety of its students, but also that its students feel safe.
-
LACDR EMA Lunchtalk
On Friday the 29th of October, LACDR presented highlights of its research and teaching program during an online Lunchtime Talk session at the European Medicines Agency (EMA).
-
Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
-
Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
-
Terrorism and Counterterrorism Studies
Terrorism has been one of the most important threats to peace, security and stability in many parts of the world. But what does this mean? What is the nature of this threat? What can be done about it and how can we at least limit the impact of terrorism?
-
Digital Humanitarian Networks: Crisis Management as a Social System
Intelligence of the crowd, or in other words, intelligence of a large, random collective, exists mostly in social media platforms such as twitter. The collective does not comprise (at least not necessarily) experts on crises, just regular people mostly. Nevertheless, there is valuable intelligence to…
-
Cyber Governance and National Security: Intervening in Ungoverned Spaces
The Netherlands Ministry of Defense and Ministry of Security and Justice have requested the Centre for Terrorism and Counterterrorism to complete a research project on cyber governance from a policy perspective. The results of this project will contribute to the deliverables of the fourth International…
-
Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
-
Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
-
Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
- Application deadlines
-
Mario van der Stelt
Science
m.van.der.stelt@chem.leidenuniv.nl | +31 71 527 4768
-
Gerard van Westen
Science
gerard@lacdr.leidenuniv.nl | +31 71 527 3511
-
Eline Dekeyster
Faculteit der Sociale Wetenschappen
e.a.g.dekeyster@fsw.leidenuniv.nl | +31 71 527 2727
-
Roxanne Kieltyka
Science
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
-
Madeline Kavanagh
Science
m.e.kavanagh@lic.leidenuniv.nl | +31 71 527 3527
-
Interdisciplinary research and teaching at Leiden University
Many of the challenges of our time are too complex to be resolved within the confines of a single discipline. Leiden University is a broad-based university where an incredible number of research fields converge. That makes us the ideal breeding ground for, and practitioners of, interdisciplinary research…
-
Inventorying and monitoring of laws and policies related to dealing with ‘jihadism’
An international comparative study of the Netherlands, Belgium, Denmark, France, Germany, the United Kingdom and the United States.