1,542 search results for “high throughput screening and microscopy” in the Public website
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efficient Advanced DNA-based methods for specific Traceability issues and High Level On-site applications
Schneider
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Receptor Residence Time
Research question
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Rob van Wijk
Science
r.c.van.wijk@lacdr.leidenuniv.nl | +31 71 527 4505
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Topic: Self-management in chronic diseases
Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…
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Start-Ups
The entrepreneurial spirit is highly present among the SBB students. The many (successful) spin-off companies from Leiden University brought by (former) SBB students are proof of this.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Data mining and algorithm development
Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…
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Key publications
Key publications of the Cancer Drug Target Discovery group
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New transmission microscope for low-energy electrons
Physicist Daniël Geelen has developed a new microscope that uses low-energy electrons. Those are less harmful to biological and organic materials. Geelen defends his PhD thesis on May 31st.
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Paving the path between low- and high-mass star formation: dynamics probed by Herschel far-infrared spectroscopy
Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)
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The High Representative in Bosnia-Herzegovina: The Unusual Institutional Arrangement of a Non-Authoritarian, Yet Controlled, Democracy
In this article, Gerrit Dijkstra and Jos Raadschelders from the Institute of Public Administration, argue that Bosnia-Herzegovina survives so far on the basis of negative legitimacy.
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Solution to distortion effect STM scanning
STM scanning experiments on poorly conducting materials are challenging, and can cause a distortion effect. A new model corrects for this effect, allowing physicists to better study materials in their quest to understand unconventional superconductivity. Publication in Physical Review B as Editor’s…
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Mighty microscopy
Festival
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Getting students away from screens... and into the landscape
Leiden University's International Honours College, Leiden University College The Hague (LUC) experienced empty halls and empty classrooms this past year on the residential campus on the Anna van Buerenplein in The Hague due to the global pandemic. Dr Paul Hudson designed a Covid-proof course that enabled…
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Shadow Game Screening with film maker Els van Driel
On 10 March students of the advanced master's in International Children’s Rights and the Dutch Child Law master's watched the documentary Shadow Game with filmmaker Els van Driel.
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New theory on liquid crystals with high symmetry
LCD screens use liquid crystals which have a high degree of order, even though they form a fluid. A new theory maps out the interplay between order, temperature and symmetry. Publication in Physical Review X.
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Understanding the Surface Structure of Catalysts and 2D Materials at the Atomic Scale
The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.
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sample preparation and handling strategies for automated and high-throughput metabolomics
PhD defence
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Should the VOG screening process be extended to include administrative fines?
Research shows that including administrative fines in the screening process for a Certificate of Conduct (in Dutch: VOG) is not currently feasible.
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Film Screening: Crip Camp
Arts and culture, Conference | D&I Symposium
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Screening enormous databases to find a cure for cancer
Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’
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machine learning algorithm for prediction and generation of High-Energy Physics data
Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.
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Training and courses
There are several training oportunities within the cell observatory
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Research projects
An overview of research themes and projects at ABS.
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Colloquium: Imaging Electrochemical Reactions by Operando Optical Microscopy
Lecture
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Film by CADS alumna Loes Moree screened at Field Recordings in Rotterdam
The film MعLMIN made by Visual Ethnography alumna Loes Moree will be screened during the fourth Fieldrecordings event. Field Recordings is an annual event for visual anthropology, sound art and landscape film.
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laissez-faire politics. Public discourses on political authorities in high-trust countries during the COVID-19 pandemic
This study looks at population response to government containment strategies during initial stages of the COVID-19 pandemic in four high-trust Northern European countries–Denmark, Germany, the Netherlands, and Sweden–with special emphasis on expressions of governmental trust.
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simulations to understand the excess baryonic mass in the centres of high-mass, early-type galaxies
This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…
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Expertise
The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.
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Imaging and Bioinformatics
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Research
Research at the BIOSYN group is comprised of the following research themes:
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Better screening can help GPs recognise anxiety disorders earlier
Only one in five young people with emotional health problems such as an anxiety disorder receives appropriate professional help. GPs often fail to properly recognise the signals in children and young people, according to psychologist Semiha Aydin. How can we improve this? PhD defence 23 February.
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Expertise
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…
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Vision and Imaging
On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…
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Podcast: Understanding High Sensitivity
High sensitivity, or sensory processing sensitivity, is increasingly discussed in popular media, but what does it actually mean to be highly sensitive? In this episode, Véronique de Gucht, associate professor at Leiden University, shares her expertise on this topic.
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Leiden Genome Technology Center
The facility develops and applies advanced, high-throughput methods for genomic research.
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Versatile SNP genotyping
The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…
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Hai Lin
Science
h.x.lin@cml.leidenuniv.nl | +31 71 527 7460
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Kristian Rietveld
Science
k.f.d.rietveld@liacs.leidenuniv.nl | +31 71 527 7038
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History is a matter of a longing for rifles and flat screen TVs
History can be found in utensils and in interviews with ordinary citizens. ‘With the reconstruction of everyday life, an anthropological approach works better,’ thinks historian Jan-Bart Gewald. Inaugural lecture on 6 June.
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Interactions in Designer Materials Unveiled
Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.
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Meindert Lamers
Science
m.h.lamers@biology.leidenuniv.nl | +31 71 527 2727
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Merijn de Bakker
Science
m.a.g.de.bakker@biology.leidenuniv.nl | +31 71 527 5043