3,479 search results for “modelling ” in the Public website
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Carlotta Rieble
Faculteit der Sociale Wetenschappen
c.l.rieble@fsw.leidenuniv.nl | +31 71 527 2727
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Kyra Verboon
Faculteit der Sociale Wetenschappen
k.e.verboon@fsw.leidenuniv.nl | +31 71 527 2727
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Modeling progress: event types, causal models, and the imperfective paradox
Lecture, Com(parative) Syn(tax) Series
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HomininSpace – a large scale simulation system for hominins in the past
HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…
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Computational User Modelling
Lecture
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Children's stories as a window to investigate empathy
Researcher Max van Duijn and PhD student Bram van Dijk apply language models to stories told by children to investigate empathy. For this research, they received the Best Paper Award at the Computational Natural Language Learning Conference in Singapore.
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The developing infant gut microbiota: mathematical predictions of the effects of oligosaccharides
A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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MULTIPLY - MULTIscale SENTINEL land surface information retrieval Platform
Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.
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Laurens Smit awarded for best PhD student in Operations Research/Management Science
The New Jersey Chapter of the international Institute for Operations Research and the Management Sciences
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Interactions from lipid membrane deformations
Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.
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‘Seeing voices’: the role of multimodal cues in vocal learning
Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Weathering the Ice Age
Where did species survive the cold cycles of the current Ice Age?
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Micha Drukker
Science
m.drukker@lacdr.leidenuniv.nl | +31 71 527 6271
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Jan Willem Erisman on the nitrogen crisis: 'The measurement model works, but the minister is setting reduction targets that are too high'
Opponents of drastic nitrogen measures argue that the nitrogen calculation model is not reliable enough. Nitrogen professor Jan Willem Erisman: 'It is now much more important to discuss the choices we make on the basis of the outcome. The differences are much bigger than the uncertainties in the mod…
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Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Advances in Survival Analysis and Optimal Scaling Methods
This thesis is based on five papers on several topics.
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Bamboo
Biodiversity and trade: mitigating the impacts of non-food biomass global supply chains.
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Joost Beltman
Science
j.b.beltman@lacdr.leidenuniv.nl | +31 71 527 4323
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Evaluation Metrics and Model Performance Workshop
Workshop Series
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Models of Nonlinear and Stochastic Astrochemical Kinetics
PhD defence
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Statistical Science
The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.
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Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Hai Lin
Science
h.x.lin@cml.leidenuniv.nl | +31 71 527 7460
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Yumeng Wang
Science
y.wang@liacs.leidenuniv.nl | +31 71 527 2727
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Marjolein Fokkema
Faculteit der Sociale Wetenschappen
m.fokkema@fsw.leidenuniv.nl | +31 71 527 7996
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Amelie Müller
Science
a.muller@cml.leidenuniv.nl | +31 71 527 2727
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Tijm Lanjouw
Faculteit Archeologie
t.j.r.lanjouw@arch.leidenuniv.nl | +31 71 527 2727
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Masha Medvedeva
Faculteit Rechtsgeleerdheid
m.medvedeva@law.leidenuniv.nl | +31 71 527 2727
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Tycho Jongenelen
Science
t.jongenelen@cml.leidenuniv.nl | +31 71 527 2727
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Oda Nuij
Faculteit Archeologie
o.m.nuij@arch.leidenuniv.nl | +31 71 527 2727
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Xiaoyang Zhong
Science
x.zhong@cml.leidenuniv.nl | +31 71 527 5148
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Stefano Merciai
Science
s.merciai@cml.leidenuniv.nl | +31 71 527 2727
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Maria Yazdanbakhsh
Faculteit Geneeskunde
m.yazdanbakhsh@lumc.nl | +31 71 526 5067