382 search results for “blood vessels” in the Public website
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Lab facilities Developmental and Educational Psychology
Social anxiety and factors determining school success in children. Brain development in relation to cognitive, social and emotional development in adolescence.
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Reactive Copolypept(o)ides as Novel Material for Systemic siRNA Delivery
The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors
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Dynastic Identity in Early Modern Europe - Rulers, Aristocrats and the Formation of Identities
Aristocratic dynasties have long been regarded as fundamental to the development of early modern society and government. Yet recent work by political historians has increasingly questioned the dominant role of ruling families in state formation, underlining instead the continued importance and independence…
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Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.
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Magnetic Resonance Microimaging of Alzheimer's Disease
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…
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Mathematical Institute
The Mathematical Institute is responsible for the research and education in mathematics and statistics at Leiden University.
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Measuring sulfur with satellites
Seagoing vessels may emit fewer and fewer harmful substances, but how do you measure whether they comply with the standards? The Dutch Environment and Transport Inspectorate (ILT) and the universities of Leiden and Wageningen are starting a joint study to detect the emission of sulfur and nitrogen dioxide…
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Athens
Athens is universally known as a symbol of democracy, philosophy, and ancient Greek aesthetics. Some of the most famous classical monuments, including the Parthenon and the temple of Hephaestus, can be found here.
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Research methods
Because we cannot directly ask babies about what they know or what they are thinking about, we must find smart and baby-friendly ways to figure it out! Below you can read about the different methods that we typically use in our studies.
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…
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Vici grants for seven researchers from Leiden University
From research on stellar winds to sign language: an impressive seven researchers from Leiden University will receive a prestigious Vici grant from the Dutch Research Council (NWO).
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Tell Ibrahim Awad
Update : August 2017 Dr Willem van Haarlem
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APELAFICO: Acoustic ecology of PELAgic FIsh COmmunities: A study into the effects of construction and operation of wind farms
Do offshore windfarms affect the local biodiversity of the pelagic fish community and are fish deterred or attracted by sounds?
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Why Things End
Studies on the Disappearance of the Amphora Phenomenon
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Publications
For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.
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Medicine
The Faculty of Medicine
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Cationic liposomes loaded with a synthetic long Peptide and poly(i:C): a defined adjuvanted vaccine for induction of antigen-specific T cell
For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…
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Research
Knowledge on how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically-ill patients, is not only crucial for novel compounds, but also for existing drugs which are often used in an off-label manner in these special patient…
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Politics: Chinese migration
Chinese organisations increasingly operate across the borders of China, and growing numbers of people from outside China are coming to live there. Professor Frank Pieke believes these movements have a significant effect on central and local government policy in China.
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Minerva in her Study
Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…
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AI in Neuroscience: Development of Methods to make Personalized Predictions for Migraine and Stroke from E-Health Sensor Data
The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.
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Babylab
Psycholinguistic research
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Protease-Responsive Targeted Delivery of Chemotherapeutics Holds Great Promise for the Treatment of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest common cancer, with only 8% of patients surviving for five years. One reason for this poor outcome is that current chemotherapy treatments are highly toxic, often leaving patients too sick to receive treatment or forcing doctors to lower the dose…
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Guadeloupe
Between 1993 and 2000 the Faculty of Archaeology had a formal cooperation with the Service Régional de l’Archéologie de la Guadeloupe, Direction Regional des Affaires Culturelles (DRAC) and the then director André Delpuech. During that period surveys and excavations were carried out at a number of s…
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Leiden scientists map cell types in fetal kidney
Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…
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The Netherlands becomes global player organ-on-chip technology
Organ-on-chip technology is used in drug research and customized treatments for patients. Research Institutes and industry join forces within the Institute for human Organ and Disease Model Technologies (hDMT) that was officially launched on May 18. Combining facilities, people and expertise will allow…
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Key publications
Key publications of the Cardiovascular Pharmacology group
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Making the most of the first time a medicine is administered to humans
Collecting as much information as possible about administering a new medicine to people can save a lot of money.
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Research in Africa reduces health spending and prevents diseases of affluence
Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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Cancer cells: A closer look
What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.
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Applied statistics as a pillar of data science
Data science is now growing fast in many places, but scholars at Leiden University have been developing data science techniques for a long time already. Thanks to their broad-based expertise, Leiden statisticians are currently combining the achievements in statistics with the latest methods of statistical…
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Leiden Institute of Advanced Computer Science
Digital technology is changing academia and society at lightning speed. LIACS is in the midst of this with groundbreaking research into data processing and artificial intelligence (AI). It conducts a unique combination of fundamental and applied research into major issues facing academia and society…
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Key publications
Key publications of the Predictive Pharmacology group.
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Topic: Aging and neuropsychological rehabilitation
Cognitive decline (amongst other problems with attention, concentration, memory) is a common symptom in patients with a variety of brain disorders and has been related to healthy ageing as well. People suffering from cognitive deficits are often significantly hampered in their day-to-day functioning…
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Immune Activation and Tolerance
The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…
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Repair a bad kidney or make a new one to order
Searching for ways to delay the need for a transplant and trying to build kidneys to order.
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Physiological responses to a social-evaluative situation
How is the development of physiological responses to social evaluation in adolescence affected by other normative developments, such as pubertal, socio-cognitive and psychosocial development? Are social anxiety and public speaking anxiety associated with characteristic patterns of stress responses…
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Distracted consumption and compensatory mechanisms
A research into the consumption experience and consumption behaviour.
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Webinar Transfusion Medicine and Cellular and Tissue Therapies
Study information
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New cell therapy facility at Leiden Bio Science Park
American pharmaceutical company Bristol Myers Squibb will be building a new (CAR-T) cell therapy facility in the Oegstgeest part of the Leiden Bio Science Park. The company will manufacture and develop CAR T-cell therapy for patients with blood cancer (leukaemia), for example.
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First clinical trial with genetically modified malaria vaccine completed
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.
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The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes
Venomous animals serve as models for a variety of mimicry types. Michael Richardson (IBL) and his international colleagues find that a group of fishes (called fangblennies) evolved venom after the origin of their venom-delivering fangs.
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2012 Spectacular finds Fieldschool 2012 Anse Trabaud
In June and July 2012 a Leiden Fieldschool was conducted at the late pre-Columbian site of Anse Trabaud in southeastern Martinique. High levels of preservation and waterlogged contexts revealed spectacular finds.
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Europa Institute participates in Odysseus Summer School
Europa Institute staff members Jorrit Rijpma, Melanie Fink and Kristof Gombeer participated last week in the Odysseus Network’s Summer School on EU Immigration and Asylum Law and Policy (Brussels, 2-13 July).
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Liesbeth de Lange wins Lewis B. Sheiner Career Prize
Pharmacologist Liesbeth de Lange has won the Lewis B. Sheiner Lecturer Award from the International Society of Pharmacometrics (ISoP). As Professor of Predictive Pharmacology she is working, among other things, on a mathematical model that can predict drug concentrations in the brain. On the occasion…