2,676 search results for “cancer drug resistance” in the Public website
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Borderline between cancer and thrombosis
Winning a prestigious award for PhD researchers, even before you have your doctorate: that's what Yascha van den Berg managed to do with his research proposal on alternatively spliced tissue factor, a protein that may be involved in tumour growth. Van den Berg: ‘It all started as a Friday afternoon…
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GMP facility for innovative drugs (KFT-J10 / IGFL)
The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.
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Laura Heitman uses her expertise to fight cancer
Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.
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Finding unique drug structures with artificial intelligence and chemistry
In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.
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vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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The EPIC Alliance joins forces to combat antibiotic resistance
No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.
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Antibiotic resistance: an economic problem universities could help to solve
Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.
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Attitude Switch: unraveling breast cancer cell-intrinsic mechanisms that manipulate the immune system
PhD defence
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Multifaceted Roles of Grainyhead-like Transcription Factor- 2 in Breast Cancer
PhD defence
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SPECT/CT-guided elective nodal irradiation for head and neck cancer
PhD defence
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New zebrafish study to understand human cancer
Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.
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Growth Fund invests many millions in faster and more sustainable (cancer) drug development
On 14 April, the National Growth Fund awarded million euros in grants to two consortia in which Leiden's science faculty is involved. Pharma-NL will receive 80 million euros and Oncode-PACT 325 million euros. Pharma-NL wants to make medicines available to the patient faster and more sustainably. Oncode-PACT…
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transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Developing drugs with artificial intelligence
Developing new drugs is a difficult process. With the aid of artificial intelligence, Pharmaceutical scientist Xuhan Liu has developed methods that can help make drug design cheaper and faster. PhD defence on 15 February.
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Taking a closer look at resistance to tuberculosis bacteria
Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…
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Promising new technique to treat cancer receives NWO grant
Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Using AI to Combat Drug Resistance - an Interview with PhD student Rosan Kuin
Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…
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‘Genetic variants could help determine whether breast cancer is hereditary’
We already know a lot about genetics and the risk of breast cancer. But much still needs to be done in breast cancer genetics to improve the prognosis and make sure women at high risk aren’t missed. This is what Professor by Special Appointment Marjanka Schmidt will say in her inaugural lecture on 4…
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Stefano Coppola Receives AXA RF Fellowship to Study Pancreatic Cancer
Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.
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Specialised immune cells have potential for new cancer immunotherapies
Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…
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Ghosts Here and There: Spectral Resistance and Dialogue in Postcolonial Literature
The ethics of ghosts, spectres, and mediums in postcolonial literature
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Business Against Markets: Employer Resistance to Collective Bargaining Liberalization During the Eurozone Crisis
Employer organizations have been presented as strong promoters of the liberalization of industrial relations in Europe. This article, in contrast, argues that the preferences of employers vis-à-vis liberalization are heterogeneous and documents how employer organizations in Spain, Italy, and Portugal…
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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Immune system plays dual role in breast cancer
The immune system plays a paradoxical role in the spread of breast cancer. Some immune cells contribute to metastasis, while other cells can be activated to strengthen the effect of chemotherapy. Kelly Kersten made this discovery in her PhD research. PhD defence 7 February.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Slave in a Palanquin: Colonial Servitude and Resistance in Sri Lanka
For hundreds of years, the island of Sri Lanka was a crucial stopover for people and goods in the Indian Ocean. For the Dutch East India Company, it was also a crossroads in the Indian Ocean slave trade. Slavery was present in multiple forms in Sri Lanka—then Ceylon—when the British conquered the island…
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Monitoring drug-related homicides: An assessment of existing data sources and potential for future monitoring
This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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namic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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generation human IPSC-derived reporter systems for image-based analysis of drug adversity
Analysis of drug adversity
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Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Resistance against the Achaemenid Empire: The Egyptian Rebellions of 521 and 487/86 BC
On 15 February 2023 Uzume Wijnsma successfully defended a doctoral thesis and graduated.
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Metabolomic fingerprint biomarkers to guide antibiotic therapy and reduce resistance development
Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…
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in primary care: a multi – dimensional approach to antimicrobial resistance
PhD defence
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The role of animals in the epidemiology of antimicrobial resistance in humans
PhD defence
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Tackling messy blood vessels to fight cancer
With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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Detecting pediatric cancer with bacteria
Ariane Briegel wants to use bacteria to detect cancer at an early stage. Together with postdoc Alise Muok, she is developing a method to quickly and cheaply test the urine of patients for the presence of suspicious molecules. They receive a grant of approximately 150,000 euros from the Dutch Cancer…
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New technique offers chemists unprecedented control in drug research
Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…
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Breast cancer risk more accurate after genetic test
Leiden University Medical Center (LUMC) has spent the past five years coordinating an international study of genetic mutations and breast cancer risks. The results will make it easier to determine which genes increase the risk of breast cancer and to what extent. The researchers published their results…
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Erik Danen
Science
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies
On 7 September, Francesc Claret Traid defended the thesis 'On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies'. The doctoral research was supervised by Afshin Ellian and Gelijn Molier.
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throughput microscopy for cellular adaptive stress response pathways in drug adversity
High throughput microscopy
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Hildert Bronkhorst
Science
h.bronkhorst@biology.leidenuniv.nl | +31 71 527 4964