10,000 search results for “leiden” in the Public website
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Development of an in vitro vascular network using zebrafish embryonic cells
How can we culture an artificial vascular network to support tissue development ex vivo?
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TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
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Neutrinos From the Milky Way
Promotor: M. de Jong, Co-Promotor: Samtleben
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Highly Accurate Simulations and Benchmarking of Molecule-Surface Reactions
Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.
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Contempt of court
On 18 December 2019, Marianne Lochs defended her thesis 'Contempt of court'. The doctoral research was supervised by Prof. C.P.M. Cleiren and Prof. J.H. Crijns.
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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The research-teaching nexus in the humanities: Variations among academics
Central in this thesis are the various forms the research-teaching nexus can take in the university, especially in the Faculty of Humanities. The importance of a strong relation between research and teaching is advocated by many academics, but debate is going on about the forms this strenghthened relation…
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Kearifan Kesehatan Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?
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Josua van Iperen (1726-1780) : gereformeerd predikant ten tijde van de Verlichting
Willem Peene defended his thesis on 12 January 2017
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Statistical learning for complex data to enable precision medicine strategies
Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.
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Het Nederlandse prefix ge- in historisch perspectief. ‘Ge-+werkwoordstam’-afleidingen in grammatica’s, woordenboeken en teksten
The Dutch prefix ge- in historical perspective gives first of all a general account of the development of the word formation processes involving ge- in which special attention is paid to the participial ge-.
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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The lead zeppelin: a force sensor without a handle
Promotor: T. H. Oosterkamp
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The Agta of the Northern Sierra Madre. Livelihood strategies and resilience among Philippine hunter-gatherers
Promotores: G. Persoon, R. Schefold
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A semisynthetic peptide-metalloporphyrin responsive matrix for artificial photosynthesis
This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.
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Orchestration of Distributed LOFAR Workflows
The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.
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Kidung Surajaya: Suntingan Teks, Terjemahan dan Analisis Makna Isi Teks
Kartika Setyawati defended her thesis on 12 November 2015
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A grammar of Sandawe: A Khoisan language of Tanzania
This dissertation presents a description of Sandawe, a Khoisan language spoken by approximately 60 000 speakers in Dodoma Region, Tanzania.
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Judeans in Babylonia: A Study of Deportees in the Sixth and Fifth Centuries BCE
Tero Alstola defended his thesis on 21 December 2017
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The Lives Of Cold War Afro-Asianism
The Afro-Asianism of the early Cold War has long remained buried under the narrative of Bandung, homogenising and subverting the different visions of post-colonial worldmaking that co-existed alongside the Bandung project.
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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The future is Brightspace
Brightspace will fully replace Blackboard in academic year 2020-2021. Following evaluations of students and lecturers’ first impressions of Brightspace, the project team now plans to make this digital learning environment more user-friendly.
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Education
LIAS faculty teach and carry out thesis supervision in many programs.
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Inhibitors and probes targeting PslG
Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…
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Casting light on the ƞ Carinae puzzle
Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura
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Van der Meer, Janssen & Louwerse, ‘The predictive value of polls in a fragmented multi-party system’
Political scientists Tom van der Meer, Lisa Janssen (University of Amsterdam) and Tom Louwerse (Leiden University) analyse polls presented by the main polling agencies in the Netherlands, as well as micro-level panel data. They reach three main conclusions. First, vote intention polls in the Netherlands…
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Knots in plasma
A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.
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Lab facilities Clinical Neurodevelopmental Studies
Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.
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Communities, Environment and Regulation in the Premodern World: Essays in Honour of Peter Hoppenbrouwers
Who had a say in making decisions about the natural world, when, how and to what end? How were rights to natural resources established? How did communities handle environmental crises? And how did dealing with the environment have an impact on the power relations in communities?
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Deep learning for visual understanding
With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Tuning in to the feedback bassline: revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Ecological functions and environmental fate of exopolymers of Acidobacteria
Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.
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Hensen Lab - Quantum Magnetomechanics
Welcome to the Hensen Lab! We are a young dynamic experimental research group starting at the Leiden Institute of Physics. Our lab addresses one of the key challenges of modern physics: understanding the interface between quantum mechanics and general relativity.
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Seeking Futures, Shaping Pasts: The fragmented nature of the political in Kashmir
Idrees Kanth defended his thesis on 7 May 2019
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Feeling safe at the university
Our university community is the heart of our academy. It is very important for Leiden University that our staff and studentsenjoy coming here to work and study and are able to carry out their activities without any hindrance.
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The Spirit of the Page: Books and Readers at the Abbey of Fécamp, c.1000-1200
This dissertation examines how Benedictine monks at the Abbey of Fécamp designed, produced, and read books over the course of the eleventh and twelfth centuries.
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On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
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Galactic substructures as tracers of dark matter and stellar evolution
One of the most important puzzles in modern astrophysics is the nature of dark matter.
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Superstructures of lipids and graphene
This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.
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Squaramide-based supramolecular polymers
Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.