1,912 search results for “computer aided drug design” in the Public website
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How oxygen deprivation causes cancer cells to spread
In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…
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'Personalized medicine' as ideal in treatment of psychiatric disorders
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Tiny joints for reconfigurable microstructures
Leiden physicists exploit self-assembly of small particles to someday create functional structures such as micro-robots from the bottom up. They have now taken an important step forward by experimentally realizing joints at micrometer scale. Publication in Nanoscale.
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‘Sleep should play a greater role in lifestyle research’
Sleep disorders have a significant influence on our physical and emotional health. Sleep should therefore receive more attention within lifestyle medicine, says Professor Gert Jan Lammers. He will give his inaugural lecture on Friday 20 May entitled: ‘Getting to sleep’.
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Snake venom glands grown in lab
For the first time, researchers were able to grow organoids from snake venom glands. The lab-grown 3-D structures can produce snake venom molecules. This is a major step in finding treatments to tackle snakebite, which causes over 100,000 deaths each year. Publication in top journal Cell.
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Visit the Leiden preliminary heat of FameLab
Which two Leiden scientists will present their research in the most compelling way in three minutes? It could be those with the most supporters. The Leiden preliminary heat of FameLab is taking place on 14 February. Sign up now to be in the audience!
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Bas Goulooze wins prestigious prize for research withdrawal symptoms in children
Pharmacometrist Bas Goulooze has won the prestigious Lewis Sheiner Student Session award. He received the prize of 300 euros at the annual conference of the Population Approach Group Europe (PAGE) in Stockholm, where he presented his research for 800 people.
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Corona research crowdfunder attracts media attention
Within a month, the Wake Up to Corona crowdfunding campaign had already raised 600,000 euros for corona research in Leiden. The goal is to raise enough money for the LUMC to set up a second laboratory that is safe enough for research into the new virus. The initiative has not escaped the attention of…
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Cleaning up tuberculosis and salmonella infections
The cellular recycling system in zebrafish is capable of eating harmful bacteria and thus resist infections such as tuberculosis and salmonellosis. That is written by Leiden biologists from the group of Annemarie Meijer. Stimulating this form of defence could be used in new treatment methods against…
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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Safety testing of chemicals without laboratory animals
Testing chemical substances without using animals. It seems a utopia, but a European team is going to develop a way to make this a reality. The RISK-HUNT3R project, led by Leiden professor Bob van de Water, received 23 million euros from the European Commission for this purpose. The project was launched…
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The brain on alert
When focussing attention, the neurotransmitters noradrenaline and acetylcholine play an important role. This new finding made by psychologist Stephen Brown provides clues for further research on how focussed attention comes about. Dissertation defence on 16 June.
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How brain disorder models are like the Night Watch
Professor of Human Genetics Willeke van Roon will give her inaugural lecture on Monday 28 March entitled: ‘Translational research, where small parts make the bigger picture.’ She will emphasise how university medical centres should take responsibility for finding treatments for very rare diseases.
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Greed and fear hamper cooperation
Everyone benefits when cooperation runs smoothly However, people often act obstructively. Why do they do that? Professor of Social Psychology Carsten de Dreu researches this issue using a wide variety of methods, from brain scans to the role of religion. Inaugural lecture 7 October.
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Visit of the Ambassador Mayerfas to Leiden University
On Thursday 24 June HE Mr Mayerfas and Cultural Attache Mr Din Wahid visited Leiden University to meet with President Annetje Ottow.
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New funding for advanced microscopy using gold nanorods
A consortium of researchers from the Leiden Institute of Physics (LION), the Institute of Biology Leiden (IBL), and the Leiden Institute of Chemistry (LIC) received a FOM program grant to develop a novel way of studying individual proteins inside a cell using gold nanorods.
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Broad universities favourable for innovation
Broad universities that focus strongly on fundamental research have the best chance of contributing to economic innovations, for example in the life and data sciences. This is the message of Professor Simcha Jong in his inaugural lecture on 14 November.
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Executive Board column: Annetje Ottow on the importance of student associations
Now the introduction weeks can go ahead as usual, the new students’ enthusiasm is overwhelming. It’s back to normal for the student associations too, having had a hard time of it during the pandemic.
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ERC Starting Grant for Roxanne Kieltyka: stem cells in gels
Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.
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Disrupted movement makes macrophages more lethal to tuberculosis bacteria
Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…
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Predicting and preventing Covid-19: 1 million euros for corona research
How is it that some covid-19 patients are affected much worse than others? Can we predict beforehand which of them will develop critical symptoms Professor Thomas Hankemeier, together with a diverse consortium of universities, academic hospitals and industrial partners, is looking for the answers to…
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Teacher of the year 2019 Fouzia Lghoul-Oulad Saïd is always ready to answer questions
Last January, the education assessors of the different study associations chose Fouzia Lghoul-Oulad Saïd of the Leiden Academic Centre for Drug Research (LACDR) as teacher of the year. Her passion for teaching extends beyond her classes, according to the students who nominated her: ‘ She is always ready…
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Chasing nanoplastics
How dangerous are micro- and nanoplastics? Do they affect the environment? What harm can they do to our bodies? Questions that we can now finally answer because of Fazel Abdolahpur Monikh. Together with his colleagues, he developed a method to detect and quantify nano-sized plastics. Their paper has…
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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New zebrafish study to understand human cancer
Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.
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Explore Brazil with Studium Generale
The Olympic Games will start in Brazil on 5 August. You can find out more about this fascinating but complex country in a series of lectures organised by Studium Generale.
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Leiden Bio Science Park acclaimed best business park in the Netherlands
On 8 October, the Leiden Bio Science Park won the Menzis award for the Best Business Park 2009. The jury particularly praised the fact that 25 years ago when the park was founded, the choice was made in favour of the biomedical life sciences, a specialisation still successful today.
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Psychology Elevator Pitch: How a better sleep pattern makes students mentally healthier
Do you often find yourself exhausted in the lecture hall or at your workplace? Not great for your mental well-being, as Laura Pape knows. She is investigating how an online self-help program can assist in addressing sleep issues and preventing mental health problems. Join her on this elevator pitch…
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LUF grant for Neeltje Blankenstein: 'I want to study online risk behaviour of young people in it's full depth'
Neeltje Blankenstein receives an LUF grant to conduct research on online risk behaviour among young people. What risks do young people take online and why? 'With this research, we not only want to help prevent serious risk behaviour, but also understand what drives young people to it.'
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Tiny, pain-free vaccinations: microneedles and nanoparticles
If it’s up to PhD student Guangsheng Du, patients don’t need to worry about big needles anymore. At the Leiden Academic Center for Drug Research (LACDR), he studied the use of microneedles and nanoparticles as a new vaccination system. ‘I want to create a more patient-friendly delivery method.’ He defends…
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Functional architecture of the brain revealed
An international partnership of brain researchers from 35 research centres - from the US to China - including the Leiden Institute for Brain and Cognition (LIBC), has collected resting-state functional MRI data from more than 1400 healthy volunteers and put the information online so that it is available…
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Young transgender people are able to decide about puberty blockers
Young transgender people are able to decide together with their parents on a reversible intervention with puberty blockers. These are the results of a study by LUMC Curium and Amsterdam UMC of 74 young people undergoing treatment. Ninety percent of the young people studied proved able to make an informed…
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Brains react differently to ADHD medication than expected
A tried and tested medication for treating ADHD works differently than expected in the brains of healthy individuals during rest: rather than stimulating brain activity, it suppresses it.
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‘The favourite candidate in the Mexican presidential election is another Trump.'
Mexico will be electing a new president on 1 July. No matter who wins, there will be little change in the deep political crisis affecting the country. This is the message given by José Carlos G. Aguiar, university lecturer in Latin American studies.
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Bio Science Park to become Bio Science Campus
The Leiden Bio Science Park (BSP) will become a real campus in the coming years, with more houses, and attractive places where scientists, students and entrepreneurs can meet to discuss their plans.
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Reedijk Symposium 2015 - Guest Lecturers: Prof. Bas de Bruin & Prof. Dame Carol Robinson
On Friday October 30th 2015 the sixth annual Jan Reedijk Symposium will be held. The main lectures of the day will be
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Frank Dikötter to receive honorary doctorate at Dies Natalis 2017
Historian Frank Dikötter will receive an honorary doctorate from Leiden University for his work on the history of the Chinese Republican period and the People's Republic of China under Mao. He will be awarded the honorary degree during the university's Dies Natalis celebrations on 8 February 2017.
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Pain relief without the high
Researchers at Leiden University led by Mario van der Stelt (Leiden Institute for Chemistry) have set ‘gold standards’ for developing new painkillers based on the medicinal effects of cannabis. Publication in Nature Communications.
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for the beauty of physics
Leiden Physics Poster
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The person behind the murderer
Are all murderers calculating psychopaths with an obscene predilection for bloody chainsaws? Yes, if Hollywood is to be believed, but in the real world they are generally everyday people with problematic backgrounds. Professor of Violence and Interventions Marieke Liem therefore calls for the demythologisation…
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Kiem project investigates link between violence and other health problems
‘Violence as a Population Health Problem’ is one of 33 interdisciplinary projects that have been launched thanks to a Kiem grant. The project team will analyse a large patient database to identify links between violence and other health problems. ‘Violence can also be an expression of other factors,’…
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King of Sweden visits Leiden University
Collaborating in drug discovery and health research was the goal of a visit to the Leiden Bio Science Park on 14 May by a Swedish delegation including His Majesty King Carl XVI Gustav of Sweden. The delegation visited Leiden University’s Faculty of Science.
- Dutch Missionaries and Deaf Education in Africa between 1960-1990
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Dominican Republic
To what extent is the image of the Taino settlements on Hispaniola representative for the whole island, or is it only related to a few large settlements of known caciques?
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About LUMAN
The Leiden University Medical Anthropology Network (LUMAN) brings medical anthropologists together with the aim of fostering interfaculty collaborations and creating common ground for working interdisciplinary on health-related themes in Leiden and beyond.
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Publications
Disclaimer: Manuscripts related to the Resilience Center are for academic purposes only and are not intended for mass distribution or copying. Please refer to applicable laws for fair use, including copyright holders' restrictions on publications.
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Publications
Here, you can browse the publications of the Navigation Lab Leiden:
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CrossRoads: European cultural diplomacy and Arab Christians in Palestine. A connected history (1920-1950)
This project aims to revisit the relationship between the European cultural agenda and the local identity formation process, and social and religious transformations of Arab Christian communities in Palestine, when the British ruled via the Mandate. What was the role of culture in European policies…
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Polymer‐ and Hybrid‐Based Biomaterials for delivering biotherapeutic molecules in bone and cartilage tissue
PhD defence