52 search results for “metabolism” in the Staff website
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Review paper on the potential impact drug-metabolizing enzymes on brain exposure
PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.
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What makes us ill?
Genes predict whether you have a propensity for an illness but environmental factors often have the last word: nutrition, air pollution, lifestyle, stress. The exposome as both culprit and chance. Large-scale research is being carried out into this at Leiden. Thomas Hankemeier, Professor of Analytical…
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Alexa Schrickel
Faculteit der Sociale Wetenschappen
a.schrickel@fsw.leidenuniv.nl | +31 71 527 2727
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Hans Aerts
Science
j.m.f.g.aerts@lic.leidenuniv.nl | +31 71 527 4771
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Lennart Schada von Borzyskowski
Science
l.schada.von.borzyskowski@biology.leidenuniv.nl | +31 71 527 4278
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Miranda van Eck
Science
eck_m@lacdr.leidenuniv.nl | +31 71 527 6238
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Aleksandrina Skvortsova
Faculteit der Sociale Wetenschappen
a.skvortsova@fsw.leidenuniv.nl | +31 71 527 2727
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Eline Dekeyster
Faculteit der Sociale Wetenschappen
e.a.g.dekeyster@fsw.leidenuniv.nl | +31 71 527 2727
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Ecology and genomics of Actinobacteria and their specialised metabolism
PhD defence
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Studies on molecular basics of metabolic syndrome in zebrafish
PhD defence
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Sandra Irmisch
Science
s.irmisch@biology.leidenuniv.nl | +31 71 527 2727
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EUniWell Open Lecture Series | Metabolic trajectories before the diagnosis of type 2 diabetes
Lecture, Lecture part of a series
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integration with genome-scale modelling of dopaminergic neuronal metabolism
PhD defence
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
PhD defence
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The development of molecular tools for investigating NAD+ metabolism and signalling
PhD defence
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
PhD defence
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Quantitative and miniaturised assays for structure-resolved lipidomics in metabolic disease
PhD defence
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Tomer Fishman
Science
t.fishman@cml.leidenuniv.nl | +31 71 527 2727
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Robert Verpoorte
Science
verpoort@chem.leidenuniv.nl | +31 71 527 4528
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Shiza Aslam
Science
s.aslam@cml.leidenuniv.nl | +31 71 527 2727
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Nutrition and fasting for the brain: why the Keto diet shows promise
Autism, Alzheimer’s, and bipolar disorder: can the development of these mental health conditions be influenced by the ketogenic diet? Increasingly, research suggests it might. 'For those it helps, it can be life-changing,' says neuroscientist Eline Dekeyster.
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Chao Du
Science
c.du@biology.leidenuniv.nl | +31 71 527 4947
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A high protein diet may accelerate atherosclerosis
A widely publicized research article in Nature Metabolism by scientist from the University of Pittsburgh, suggests a high protein diet which is popular among for instance fitness enthusiasts, may be harmful to the cardiovascular system. National media outlets such as NRC Handelsdagblad and NPO 1 Radio…
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‘Sleep should play a greater role in lifestyle research’
Sleep disorders have a significant influence on our physical and emotional health. Sleep should therefore receive more attention within lifestyle medicine, says Professor Gert Jan Lammers. He will give his inaugural lecture on Friday 20 May entitled: ‘Getting to sleep’.
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Maaike van der Lee wins the national PhD competition 2021 at the FIGON Dutch Medicine Days
We are congratulating Maaike van der Lee, PhD candidate at LUMC-KFT, for winning the national PhD competition 2021 at the FIGON Dutch Medicine Days. During this national competition, 8 researchers from the major university cities in the Netherlands present their work in the field of innovative medicine…
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Nature Communications paper on therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression
Cancer immunotherapy represents a significant breakthrough in cancer treatment. However, tumors have numerous mechanisms by which they evade destruction by the immune system. It is therefore necessary to decipher and reverse these mechanisms in order to improve immunotherapies.
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Can we make bioplastics with artificial photosynthesis?
Mimicking photosynthesis to produce bioplastics sustainably and efficiently. Researchers from the Institute of Biology Leiden (IBL) and the Leiden Institute of Chemistry (LIC) will assess this new approach. ‘An exciting opportunity to explore a new, appealing research topic in a collaboration between…
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Miranda van Eck new Scientific Director of the LACDR institute
As of 1 September Miranda van Eck will be the new Scientific Director of the Leiden Academic Centre for Drug Research. She succeeds Hubertus Irth, who led the institute since 2016. Van Eck has been appointed for a period of four years.
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Organ failure caused by viruses, how does it work? Now there are methods to find out
Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…
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Major international study links genes to brain structural changes over time
There seem to be genes that influence how our brains develop over time. A large international consortium has discovered this with an extensive study. The results of the study were recently published in Nature Neuroscience.
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LUMC professor Maria Yazdanbakhsh receives Spinoza Prize
Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…
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300 million euros for new international stem cell consortium
The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…
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Hard chews: why mastication played a crucial role in evolution
We do it every day but barely give it a thought: chewing our food. But the ‘simple’ process of masticating food may have played a crucial role in the evolution of our jaws, facial muscles and teeth.
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Exploration of the endocannabinoid system using metabolomics
PhD defence
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
PhD defence
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Regulation of signal transduction pathways by hypoxia in breast cancer subtypes
PhD defence
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LUMC will administer first Dutch stem cell gene therapy to patients
Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…
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Using low sample volumes to better understand brain diseases
Marlien van Mever delved into the analysis of tiny samples, cerebrospinal fluid from transgenic mouse models for example. She validated methods that can now be used to study brain diseases such as migraine and epilepsy. Van Mever will receive her PhD on 14 June.
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Difficult message for policymakers from two Leiden reports on circular economy
You should start working now, and the positive results will only be seen long after your term has expired. That is just about the worst thing you can say to politicians and policymakers. Yet that is exactly the message of two recent reports on sustainable resource use from the Centre for Environmental…
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Seven Leiden professors elected new members of KNAW
Seven Leiden professors have been elected as members of the Royal Netherlands Academy of Arts and Sciences (KNAW). In total 23 new members will be inaugurated on Monday 13 September.
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How colleagues save energy: using the stairs and cleaning up your mailbox
Turning down the heating is good for the climate and the energy bills. But there are also a lot more ways of saving energy. In October, the University put out a call to staff and students, asking them for their golden energy-saving tips. The best entries have now been rewarded with a warm snuggle hoodie…
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‘Ask scientists how to build the circular economy’
Some governments and companies are pursuing a more circular economy, but what is the best way to get there? An international group of industrial ecology researchers wrote a report that stresses the importance of including the scientific side into policies and practices. ‘We feel an obligation to support…
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Making better use of our natural resources
The availability of natural resources, the energy transition, the importance of circularity and our dependence on China. This and more is what Professor of Industrial Ecology René Kleijn's inaugural lecture is about.
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Webb detects icy ingredients for making potential habitable worlds
An international team of astronomers, led by Will Rocha of Leiden Observatory, using the NASA/ESA/CSA James Webb Space Telescope have discovered that the key ingredients for making potentially habitable worlds are present in early-stage protostars, where planets have not yet formed.
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Hoe meer tijd, hoe beter de nier
Donororganen zijn er nooit genoeg. De organen die wel beschikbaar zijn, moeten vliegensvlug getransplanteerd worden. De geneeskunde zet daarom volop in op het langer goedhouden van organen. Marlon de Haan (24) onderzoekt hoe je nieren buiten het lichaam in leven kunt houden.
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Leiden research projects awarded NWO Open Competition grants
Six researchers from Leiden University have been awarded NWO Open Competition funding.
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Stiffness and viscosity of cells differ in cancer and other diseases
During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.
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Staff symposium on student well-being – A shared path to well-being: students and staff
Conference
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Bioengineering and Biophysics of Viral Hemorrhagic Fever
PhD defence
- Urban Health Programme