1,542 search results for “high throughput screening and microscopy” in the Public website
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: J.N. Kok, Co-promotor: F.J. Verbeek
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formation and growth by nanoparticle tracking analysis and flow imaging microscopy
The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Joost Willemse
Science
jwillemse@biology.leidenuniv.nl | +31 71 527 4986
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Serkan Aslan
Science
s.aslan@lacdr.leidenuniv.nl | +31 71 527 5919
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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17 mln subsidy to develop electron microscopy in the Netherlands
The Netherlands Organisation for Scientific Research (NWO) has made a subsidy of 17 million euros available to further develop a Netherlands network for electron microscopy (NEMI). The network comprises five UMCs and eight universities, with Utrecht in the coordinating role. From Leiden, the Institute…
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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Microcoil MRI of Plants and Algae at Ultra-High Field: An exploration of metabolic imaging
This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).
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Facilities
Our facilities cover:
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Research Facilities
Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Joining hands to advance Dutch microscopy
Advanced microscopy to understand life and fight disease: that’s the goal of the new NL-BioImaging network that will develop and integrate state-of-the-art microscopy technologies and services. Researchers from all Dutch universities, including Leiden University and the Leiden University Medical Centre,…
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Xuesong Wang
Science
x.wang@lacdr.leidenuniv.nl | +31 71 527 6225
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Discovery of metastasis promoting candidate drug targets
Discovery of metastasis promoting candidate drug targets
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Crystal Cave
X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.
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Tailored care for children at high risk for problem behaviour
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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What is behind the screen? Object Individuation by 10 months old infants
Making sense of the world around us depends on the fundamental ability to parse the world into distinct objects and keep track of them. This process is defined as object individuation. Research indicates that it is not always easy for infants.
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NL-BioImaging AM
NL-BioImaging AM is a distributed research infrastructure aimed at promoting progress in the most cutting edge microscopy technologies and providing open access to these technologies to a broad community of academic and industrial users. All Netherlands bio(medical) microscopy centers participate.
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Empirical Bayes applications in biomedical high-dimensional prediction
The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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High-Contrast Imaging of Protoplanetary Disks
To study how planetary systems come into existence we study much younger systems still in formation.
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High-contrast spectroscopy of exoplanet atmospheres
More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.
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From Pixels to Patterns: AI-Driven Image Analysis in Multiple Domains
PhD defence
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High performance computing
A high performance computer or supercomputer owes its massive processing capacity to the fact that it chops a single overarching task into a whole series of smaller tasks. It simultaneously tackles each of those smaller problems.
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'Oqlanmagan – The Unexonerated': Film Screening and Discussion
Debate, Film Screening and Discussion
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Drug safety Sciences
Our research in the area of safety sciences aims to increase the mechanistic understanding of cellular toxicity of drugs and, in a broader sense, chemicals.
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Ikat from Timor and its outer islands: insular and interwoven
This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.
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Learning together about electron microscopy
Chinese and Leiden scientists came together in Leiden to study the intricacies of modern visual techniques.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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It's just a phase: High-contrast imaging with patterned liquid-crystal phase plates to facilitate characterization of exoplanets
This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.
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ALICE High Performance Computing facility
High Performance Computing (HPC) is becoming ever more important as a research tool in many research areas across all research domains. A University facility, providing serious computational capabilities, combined with easy and flexible local access, is a strong advantage for these research areas. It…
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A yeast screening method to decipher the interaction between the adenosine A2B receptor and the C-terminus of different G protein α-subunits
Source: Purinergic Signal., Volume 10, Issue 3, pp. 441-53 (2014)
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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Target Discovery
The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…
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Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
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Zebrafish Delivery
Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?
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Bob van de Water
Science
water_b@lacdr.leidenuniv.nl | +31 71 527 6223
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Joanne Mouthaan
Faculteit der Sociale Wetenschappen
j.mouthaan@fsw.leidenuniv.nl | +31 71 527 6781
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Dominik Sieh
Faculteit der Sociale Wetenschappen
d.s.sieh@fsw.leidenuniv.nl | +31 71 527 7332
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Probing molecular layers with low-energy electrons
Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…
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Subsidies for high-grade research facilities
Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…