1,696 search results for “drug safety” in the Public website
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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GTGC lunch seminar: Santino Regilme on Global Drug Wars
On the 6th of March 2023, Santino Regilme presented his work-in-progress titled 'Global Drug Wars: Contested Normative Orders of Peace, Security, and Human Rights'. If the battle against illegal drugs is construed as a war, how is victory in such a war defined and constructed? If the oppositional…
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Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Drug development: how can we make it more efficient?
It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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KNAW advisory report on social safety in Dutch academia
At the beginning of July, a committee appointed by the Royal Netherlands Academy of Arts and Sciences (KNAW) presented its report 'Social Safety in Dutch Academia. From Paper to Practice', to the Dutch Minister of Education, Culture and Science. The committee was chaired by Professor Naomi Ellemers…
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Jos Brosschot
Faculteit der Sociale Wetenschappen
brosschot@fsw.leidenuniv.nl | +31 71 527 2727
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The Muslim Brotherhood in Europe
Scholars have long debated the intentions of the Muslim Brotherhood in the Middle East. Some claim the organization supports terrorism, while others believe it is a positive force for democratization.
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Who Are They and Why Do They Go? The Radicalization and Preparatory Processes of Dutch Jihadist Foreign Fighters
How do European Muslim men and women become involved in a violent jihadist struggle abroad?
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Conspiracy, legitimacy and violence
Can conspiracy constructions explain for hatred of the system? And if so, should conspiracy constructions be considered to be a risk in terms of national security?
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
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Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?
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New publication ERC StG Safe & Sound: Safety and Exoskeletons
We are pleased to announce a groundbreaking research study delving into crucial aspects of safety and responsibility in the domain of personal care robots, explicitly focusing on robotic lower-limb exoskeletons.
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'Ministry withholding information on safety at Schiphol is serious business'
The Dutch Ministry of Infrastructure and Water Management is refusing to release documents on the safety of Schiphol Airport, despite a court ruling that they must be made public. The case has been running for four years and was brought by current affairs programme EenVandaag.
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Safety Survey: NVIC students feel very safe in Cairo
The safety of students is a priority and hence an ever recurring issue at the NVIC. NVIC not only attaches great importance to the safety of its students, but also that its students feel safe.
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Chemical firms in the Netherlands regularly break safety rules
The Dutch chemical industry is regularly in breach of safety legislation. These are the findings of longitudinal research by the Department of Criminology at Leiden University, in collaboration with the Department of Criminology at VU Amsterdam. Over the past ten years, the roughly 400 companies to…
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Accounting for diversity in robot design, testbeds, and safety standardisation
Eduard Fosch-Villaronga from eLaw - Center for Law and Digital Technologies, and Hadassah Drukarch, explored the role of intersectionality within (rehabilitation) robot design, testbed, and standards. Being oblivious to these considerations may give way to the development of robots that fall short of…
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Terrorism and Counterterrorism Studies
Terrorism has been one of the most important threats to peace, security and stability in many parts of the world. But what does this mean? What is the nature of this threat? What can be done about it and how can we at least limit the impact of terrorism?
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Digital Humanitarian Networks: Crisis Management as a Social System
Intelligence of the crowd, or in other words, intelligence of a large, random collective, exists mostly in social media platforms such as twitter. The collective does not comprise (at least not necessarily) experts on crises, just regular people mostly. Nevertheless, there is valuable intelligence to…
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Cyber Governance and National Security: Intervening in Ungoverned Spaces
The Netherlands Ministry of Defense and Ministry of Security and Justice have requested the Centre for Terrorism and Counterterrorism to complete a research project on cyber governance from a policy perspective. The results of this project will contribute to the deliverables of the fourth International…
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
- Application deadlines
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Mario van der Stelt
Science
m.van.der.stelt@chem.leidenuniv.nl | +31 71 527 4768
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Gerard van Westen
Science
gerard@lacdr.leidenuniv.nl | +31 71 527 3511
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Eline Dekeyster
Faculteit der Sociale Wetenschappen
e.a.g.dekeyster@fsw.leidenuniv.nl | +31 71 527 2727
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Roxanne Kieltyka
Science
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
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Madeline Kavanagh
Science
m.e.kavanagh@lic.leidenuniv.nl | +31 71 527 3527
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Inventorying and monitoring of laws and policies related to dealing with ‘jihadism’
An international comparative study of the Netherlands, Belgium, Denmark, France, Germany, the United Kingdom and the United States.
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The state of research on terrorism
During the 1980s and early 2000s, authors like Alex Schmid and Andrew Silke demonstrated the paucity of first-hand insights being used to study terrorism and the consequences this had for the reliability of the findings beings presented. But to what extent have these issues endured?
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Opinion: Global Safety Summit on AI avoids real issue
The first global safety summit on Artificial Intelligence is a fact. Prime Minister Sunak organised the conference because he believes that the issues related to AI can only be dealt with by governments. But the real issue with AI remained undiscussed at the summit, Reijer Passchier claims in Dutch…
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New book by Ruth Prins 'Mayors put to the test'
Book on Dutch mayors governing local order and public safety.
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Interdisciplinary research and teaching at Leiden University
Many of the challenges of our time are too complex to be resolved within the confines of a single discipline. Leiden University is a broad-based university where an incredible number of research fields converge. That makes us the ideal breeding ground for, and practitioners of, interdisciplinary research…
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Laura Heitman appointed as Professor of Molecular Pharmacology
As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…
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Becoming a European Homegrown Jihadist
The book addresses the question “How and why do people become involved in European homegrown jihadism?
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High-throughput screening for developmental and reproductive toxicity
Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Research
An overview of the research at the Biologics Formulation group