2,595 search results for “computer aided drug design” in the Public website
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Computational Network Science Lab
The Leiden Computational Network Science Lab (CNS Lab) researches methods for knowledge discovery from real-world network data.
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Computer Science & Economics (BSc)
Met de bachelorspecialisatie Informatica & Economie aan de Universiteit Leiden leer je waardevolle inzichten in de economie te combineren met (programmeer)vaardigheden en kennis uit de informatica.
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Research and design in secondary science education
Research and design are becoming more and more important in international science education. In The Netherlands, two recently introduced subjects focus on research and design activities in the classroom: O&O (research and design) and NLT (nature, life and technology). This research aims to look at what…
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Computer support group
The Computer Support group provides dedicated support for the computing infrastructure of Leiden Observatory
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Computability of the étale Euler-Poincaré characteristic
Promotor: S.J. Edixhoven, L.D.J. Taelman
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
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LED3 Lecture: Microbial Natural Products in Drug Discovery
Lecture
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Reconstruction and Computational Modelling for Inherited Metabolic Diseases
Accelerating the diagnosis and personalising the management of inherited metabolic diseases.
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GMP facility for innovative drugs (KFT-J10 / IGFL)
The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Advanced Computing and Systems (MSc)
The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.
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Computer Science and Education (MSc)
The master’s specialisation Computer Science and Education at Leiden University prepares students to teach the subject of biology to secondary school students. The programme comprises a one-year Computer Science component, followed by an education component in the second year.
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Data Science: Computer Science (MSc)
The master's specialisation Data Science: Computer Science at Leiden University provides students thorough knowledge and understanding of statistical and computational aspects of data analysis, including their application in databases, advances in data mining, networks, pattern recognition, and deep…
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Designing justice
Procedural administrative law in a constitutional comparative law perspective
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ALICE High Performance Computing facility
High Performance Computing (HPC) is becoming ever more important as a research tool in many research areas across all research domains. A University facility, providing serious computational capabilities, combined with easy and flexible local access, is a strong advantage for these research areas. It…
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television consumption and the attitudes toward people living with HIV/AIDS in Chile
We analyse the link between media consumption and the attitudes toward people living with HIV/AIDS in Chile. We used data from a sample of 1000 people, obtained in the 2011 wave of the World Values Survey (WVS). We use a logistic binary regression model by maximum likelihood. Our results suggest that…
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Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Large-scale Computing Infrastructure
Large-scale computing infrastructure, such as supercomputers, cluster, and clouds, are already pervasive, most members of our society interact with them daily: social networks, government services, media streaming services--all systems heavily interfacing with the members of our society--are powered…
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Under Construction. Cognitive and Computational Aspects of Extended Lexical Units
This dissertation investigates Extended Lexical Units (ELUs), elements that are bigger than just one word and which are stored in the Lexicon.
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Assistant Professor in Computational Biodiversity
Science, Leiden Institute of Advanced Computer Science (LIACS)
- Teaching Computer Science (MSc)
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Computer Science at Leiden University
Leiden Institute of Advanced Computer Science (LIACS)
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pandemics, and support: the role of political actors in Dutch state aid during COVID-19
How do governments distribute resources across economic sectors during a crisis? And why do some sectors receive more than others? The recent COVID-19 pandemic has highlighted the urgency of these questions. In this paper, we explore the extent to which a political economy…
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Designing Your Life
Welcome and great to see you are interested in Designing Your Life education! Whether you are a student or educator, this website has everything you need to get started.
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Quantum machine learning: on the design, trainability and noise-robustness of near-term algorithms
This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.
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Computational speedups and learning separations in quantum machine learning
This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…
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Security by behavioural design
In 2021, the National Cyber Security Centre (NCSC) asked Leiden University to conduct a rapid review of best practices and possibilities for follow-up research on the integration of behavioral sciences in security by design methodologies and projects. This academic field is called security by behavioral…
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New handbook “EU State Aids”
The Europa Instituut is pleased to announce that this week a new handbook “EU State Aids” (31 Chapters, 1500 pages) was published.
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Methods to simulate fermions on quantum computers with hardware limitations
This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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MODOMA: A computer-simulated laboratory-approach towards language acquisition
The goal of the MODOMA-project is to create a computer model of language acquisition.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Internationalisation in Fine Arts and Design Higher Education in Europe
This research intends to study the why, what, how and the possible outcome of internationalisation in higher education institutions of fine art and design.
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Origami metamaterials : design, symmetries, and combinatorics
In the first part of this thesis we study the geometry of folding patterns.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Bioinformatics Data analytics Computational Biology
LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.
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Monitoring drug-related homicides: An assessment of existing data sources and potential for future monitoring
This project’s aim is to critically assess current homicide data sources in order to develop a proposal for long-term EU-level monitoring of DRH.
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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namic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Joost Grootens
Faculty of Humanities
j.grootens@hum.leidenuniv.nl | +31 71 527 2727
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Joran Lammers
Science
j.a.lammers@cml.leidenuniv.nl | +31 71 527 2727
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Machine learning and computer vision for urban drainage inspections
Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.
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Computer Science and Science Communication & Society (MSc)
The master’s specialisation Computer Science and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in computer science with extensive training in science communication.
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Secure Multiparty Computation and Secret Sharing
The first book ever on information-theoretically secure multiparty computation