493 search results for “induced pluripotent system cell” in the Staff website
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Call: collaboration between humanities and regenerative medicine
Research
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Veni grant for ten Leiden researchers
Ten Leiden researchers have been awarded a Veni grant by the Dutch Research Council (NWO). The grant, of up to 280,000 euros, will enable them to elaborate their ideas over a period of three years.
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Superselective bonds light up
Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researchers first caught this phenomenon using spheres or colloids, and published…
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700,000 euros for the fight against aggressive breast cancer
To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…
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Flu stops when you block the enzyme that cleaves off virus particles
A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.
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Can we live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
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WCN research prize for Marie Depuydt
During the 36th Scientific CardioVascular Congress, which was held last November in Amsterdam, Marie Depuydt from the BioTherapeutics division received the 2nd prize in the WCN research competition for her work (Vereniging Werkgroep Cardiologische centra Nederland (WCN)).
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ERA4Health grants for Bram Slütter, Amanda Foks and Ilze Bot
Recently, Bram Slütter, Amanda Foks and Ilze Bot all individually obtained an ERA4Health research grant from the CARDINNOV 2023 program. In this program, which is co-funded by the EU and in the Netherlands by ZonMW, 17 consortia consisting of 3-5 European academic partners were selected for funding…
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Leiden University celebrates curiosity at 449th Dies Natalis
How has evolution shaped our curiosity? And how does that curiosity ensure that we now have the technological ability to discover whether we are alone in the universe? This was all covered during the celebration of Leiden University’s 449th Dies Natalis.
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Key for effective application of a new revolutionary cholesterol lowering drug resides in a 30 year old Leiden Patent
‘’ And then the world changed forever ,welcome to the future’’. These are the words that Kausik Ray (President of the European Atherosclerosis Society) spoke when the worldwide first dose of inclisiran, a novel SiRNA based cholesterol lowering agent, was administered at the Cardiology lipid clinic at…
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Just Public Algorithmic Systems – What does it take?
Lecture
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Maria Berghuis in EditieNL about PhD thesis: 'Prison visits are form of social control'
Prisoners who have little or no contact with the outside world are more prone to reoffend. What makes visits so important?
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How to make an old antibiotic a hundred times more potent
Nathaniel Martin, Professor of Biological chemistry, wondered what would happen if you take an antibiotic that has been known for 70 years and try to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant…
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Funding for four Leiden studies in the fight against arthritis
Four researchers from Leiden University will receive funding from arthritis foundation ReumaNederland over the next five years. This should facilitate long-term research into arthritis.
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Lingling Weng aims to improve clinical practice with placebo and nocebo effects
The placebo effect was completely new to her when Lingling Weng began the PhD project in Leiden. She is now a postdoc in China. 'It would be great to investigate the underlying mechanisms of placebo and nocebo effects with my current knowledge of EEG and fMRI.' PhD defence on 17 October.
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Scientists discover the largest stellar black hole in the Milky Way
A European team of astronomers has discovered the largest stellar black hole in the Milky Way. It is more than thirty times as massive as our sun and is located in the constellation of Aquila, about two thousand light-years from Earth. The astronomers stumbled upon the black hole by chance while preparing…
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Selective cannabinoid CB2 receptor activation in Nature Communications
This March, Jara Bouma, Cas van der Horst and Laura Heitman from the Division of Drug Discovery and Safety and Laura de Paus, Richard van den Berg, Anthe Janssen and Mario van der Stelt from the LIC joined forces to determine how some drugs can specifically target the cannabinoid CB2 receptor (CB2R)…
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In memoriam professor Jo Hermans
On Tuesday evening 22 August, our very dear colleague Jo Hermans passed away. Jo had been ill for some time, but continued to enjoy life in good spirits until the very end. He meant a great deal to Leiden University and will be remembered with fond memories by many.
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Liveable planet lunch meeting - Learning from Ancient Water Systems
Lecture
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Improving the treatment of pathogenic fungi. ‘The process is working, but not that well…’
Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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This is how physicists contribute to the energy transition
Studying surfaces of solid materials: it may not seem relevant to energy consumption, but it is. Marcel Rost studies how platinum electrodes wear out. Those electrodes are a crucial component in the fuel cells of hydrogen-powered cars. ‘We need to make the switch from fossil fuel energy to hydrogen.…
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Four Leiden consortia awarded large NWO grants
No less than four Leiden research teams have been awarded a grant by NWO. On 27 July NWO honoured 21 applications in the Open Competition ENW-XL. NWO awards the grants to consortia in the exact and natural sciences who are doing unconnected fundamental research that is 'driven by curiosity'.
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Is a cancer pill a matter of time?
A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.
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Not wrapping but folding: Bacteria also organise their DNA (but they do it a bit differently)
Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…
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Biological Origami at molecular level: folding a single protein
Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…
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From lab discovery to a new drug: the Venture Challenge makes it possible
A breakthrough from the PhD research of medical chemist Elmer Maurits may help patients with autoimmune diseases and blood cancer in the future. But bringing a discovery from the lab to the clinic is not so easily done. Thanks to NWO's Venture Challenge, Maurits and his team will receive ten weeks of…
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Interaction with Sound for Participatory Systems and Data Sonification
PhD defence
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‘Cancer treatment should be a six-week life event’
When internist Christian Blank made his very first discovery, his field of immunotherapy was the underdog of cancer research. Now, over 20 years later, Blank has been appointed Professor By Special Appointment of Internal Medicine for his clinical research into immunotherapy and will give his inaugural…
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Bioengineering and Biophysics of Viral Hemorrhagic Fever
PhD defence
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PhD research: 'Visits to prisoners reduces risk of reoffending'
Prisoners who are visited regularly by family or friends are less likely to be reconvicted in the short term than inmates who rarely or never receive visits. Visits should therefore be encouraged and facilitated, according to PhD candidate Maria Berghuis, who will defend her doctoral thesis on 23 June…
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The Netherlands and China work together to improve their wastewater management
Netherlands and China can learn from each other to handle household and livestock wastewater more sensibly. In the FOREWARD project, scientists from Leiden, Wageningen, and China are working together with local partners on feasible solutions that advance the environment, health, and economy.
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Producing all our food nationally: is it even possible?
According to a new study, for half of the world population the answer would be yes. For the other half: maybe? Leiden environmental researcher and head author Nicolas Navarre explains: ‘With improvements to crop yields, reductions in food waste, and changes in consumption patterns, 90% of people could…
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Hoe meer tijd, hoe beter de nier
Donororganen zijn er nooit genoeg. De organen die wel beschikbaar zijn, moeten vliegensvlug getransplanteerd worden. De geneeskunde zet daarom volop in op het langer goedhouden van organen. Marlon de Haan (24) onderzoekt hoe je nieren buiten het lichaam in leven kunt houden.
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Arteriosclerosis and drug discovery: two young researchers win Krijn Rietveld Award for innovative research
One discovered that arteriosclerosis resembles an autoimmune disease, while the other developed a system to aid in the search for new medications. For these achievements, Marie Depuydt and Jurren de Groot were awarded the Krijn Rietveld Memorial Innovation Award on the evening of Tuesday 4 June.
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Leideners and researchers learn from each other at the Science Market
3 October University has become something of a tradition: a bit of science among the Leidens Ontzet celebrations. During the new and improved edition, the WetenschapsWarenMarkt (Science Market), visitors spoke to researchers about the nitrogen problem, making organs and the city’s connections with A…
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Boosting the host immune system to fight tuberculosis
PhD defence
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Nano-scale Electronic Structure of Strongly Correlated Electron Systems
PhD defence
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scanning tunneling microscopy experiments into correlated electron systems
PhD defence
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Synthesis of chemical tools to study the immune system
PhD defence
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
PhD defence
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Medical Delta AI for Computational Life Sciences
The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?
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Why you should publish negative data
As a bachelor student of Bio-Pharmaceutical Sciences, Femke Vlaswinkel wrote a research proposal she was allowed to carry out in her master’s BPS. Femke subsequently graduated with honors. Her research was published in the journal Scientific Reports, she won an award from the Dutch Pharmacy Society…
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Interdisciplinary Collaboration Explores Substance P in Health and Disease
A team of LACDR scientists from three different divisions (SPP, BT, MC) contributed to a book on "Substance P in Health and Disease," which will be published by Elsevier. The project was a collaboration with Hannover Medical School (Germany) and was coordinated by Alireza Mashaghi. Master students Ehsan…
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Silicon pore optics for high-energy optical systems
PhD defence
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What does it actually say? Linguist launches video series on wall poems
The city centre of Leiden is covered in them: wall poems. When roaming around, you come across poetry written in the Latin alphabet, but also in scripts that might be more difficult to understand for the average person living in Leiden. In a new series of videos, Tijmen Pronk talks more about this.
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Veni grants for 21 researchers from Leiden University
An impressive 21 research projects by Leiden researchers have been awarded Veni funding from the Dutch Research Council (NWO).
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What rights do donors have?
Collaboration is worthwhile. A joint LUMC and Leiden Law School project has received €142,500 from the Dutch Research Council (NWO). This grant will advance research into the law and ethics of regenerative medicine.
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Organ failure caused by viruses, how does it work? Now there are methods to find out
Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…