PhD defence

Algorithm for Structural Variant Detection

• J. Lin

Date

Friday 24 June 2022

Time

10:00 - 10:45 hour

Address

Academy Building
Rapenburg 73
2311 GJ Leiden

Supervisor(s)

• Dr. W.A. Kosters
• Prof.dr. Kai Ye (Xi'an Jiaotong University)

Summary:

Structural variant (SV), the hidden architecture of human genome, are critical for us to understand disease, evolution, etc. In this thesis, we introduce novel algorithms to detect and validate complex events, and assess the reproducibility of current SV detection pipelines for clinical and research settings. Chapter 1 begins with the introduction of DNA, various types of SVs and sequencing technologies. Then fundamental techniques or algorithms from computer science related to the thesis are briefly described. Pattern mining, graph and deep learning are applied to detect and characterize different type of complex SVs (CSVs) and they are all from computer science.

PhD dissertations

Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.

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