The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Many of the most acute problems we face today are global: they transcend national boundaries, they put the future of society and even humanity at peril, and they can only be addressed through international cooperation. However, what can international cooperation deliver? Find out in the minor Ecology,…

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…

When we think of politics, we tend to think of adversary, antagonism, polarisation, a struggle for power. But politics should serve positive purposes, as well. Political psychologist and meditation teacher Femke Bakker (Leiden University) thinks that positive politics is first and foremost about tolerance.…

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

This new article by Monica Kaminska is part of a special issue for Journal of Cybersecurity, based on a selection of contributions from THe Hague Program for Cyber Norms' 2019 Conference.

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

The idea that modern humans displaced Neanderthals because they were better protected against toxic smoke components is now under fire. An earlier study that put forward this suggestion has now been refuted by genetic research by scientists from Leiden and Wageningen. This new research was published…

Bastiaan Rijpkema has been appointed Professor by special appointment of the new chair Tolerance at the Faculty of Humanities with effect from 1 July 2021. The chair was established by Stichting Leerstoel Uytenbogaert.

Fijs van Leeuwen, Professor of Radiology, Molecular Imaging and Image-Guided Therapy, advocates an open and respectful academic culture that always puts the patient first. He delivered his inaugural lecture on 13 November.

The Upper and Lower Houses of the Dutch Parliament are struggling with how tolerance should best be interpreted. As a result, the freedom in the Netherlands for people who hold alternative views is diminishing. This is Floris Mansvelt Beck’s conclusion on the basis of his PhD research. Defence on 2…

PhD candidate Demy Jongkind and Associate Professor Annemarie Drahmann – both part of the Department of Constitutional and Administrative Law – have been interviewed by the Kenniscentrum Europa Decentraal (KED) on the Dutch Services Act (DW) and cannabis tolerance policy.

Soil salinity is affecting large areas in the world and millions of farmers are faced with decreasing yields and many are even forced to migrate . Dutch scientists (Prof Dr. Gerrit van Straten (Wageningen University), Prof. Dr. Peter van Bodegom (Leiden University), Prof. Dr. Jelte Rozema (VU University…

The Salt Farm Texel, supported by a number of professors from various Dutch universities, offered a report on saline agriculture to the Minister for Agriculture van Dam on Wednesday 22nd of February. The researchers report that a number of important crops are much more tolerant to salt than assumed…

The English edition of Rijpkema’s Weerbare democratie is published in Routledge’s Extremism and Democracy series, one of the leading series in the field, edited by Roger Eatwell and Matthew Goodwin.

For a certain period the municipality of The Hague collaborated with the Salafist Quba mosque. The reason for the collaboration was to keep an eye on for radicalised youngsters. But as the collaboration progressed, the mosque became a breeding ground for Jihadists.

This year marks the 450th anniversary of the Capture of Brielle by the Watergeuzen (lit. ‘Sea Beggars’) and therefore the birth of the Netherlands. Student Johan Visser is contributing to no fewer than three books about the extraordinary year of 1572.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Everything you need to know about the minor Ecology, Migration and Tolerance: Limits to Cooperation.

Manon van der Heijden and Leo Lucassen, and Maarten Mous will receive NWO Open Competition funding. This funding amounts to a maximum of 750,000 euros and is intended to carry out research into a subject of their your own choice, without thematic preconditions.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

This study describes religion in Java.

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Due to its economic prosperity, its policy of (relative) religious tolerance, and its large numbers of migrants, the Dutch Republic has long had a reputation of being the prime example of ‘tolerance’, especially during the seventeenth century. Although the great variety of newcomers in the Dutch Republic…

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…

Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…