Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

Bikes are one of the most sustainable ways of travel which use should be promoted by the University.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

“The more you regulate the banking sector, the bigger shadow banking will get.”

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

We are delighted to welcome Dr. Barrie Sander as Visiting Fellow of The Hague Program for Cyber Norms at Leiden University’s Institute of Security and Global Affairs from 27 September till 4 October 2017.

Efficient gene-targeting during meiosis

In this article, the authors explore how international criminal law is moving into a ‘post-critical’ phase and examine its potential for emancipatory reform.

The European Commission adopted a proposal regarding common rules promoting the right to repair for consumers.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

On 27 June 2019, Barry Bussey defended his thesis 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. The doctoral research was supervised by Prof. dr. P.B. Cliteur.

On 24 May 2017, the Hazelhoff Centre for Financial Law welcomed Shen Wei, Dean and Professor of law at Shandong University School of Law in China, for the 14th Hazelhoff Guest Lecture.

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

This edited publication aims at reflecting on the future of discussions on the applicability of international law to States’ use of ICTs in the context of highly politicised discussions at the multilateral level and offering practical suggestions for the European Union to pursue its objectives in this…

This volume edited by Jan Lucassen and Leo Lucassen aims to quantify and qualify cross-cultural global migrations and was published in the series 'Studies in Global Migration History'.

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How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

PhD defence

PhD defence

PhD defence

Wanted for the Re-pair study!

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)