In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

PhD defence

Professor Tom Huizinga (LUMC) specialises in rheumatoid arthritis. He joined forces with alumni and the Natuurwetenschappelijk Gezelschap Leiden, a society that aims to share knowledge of the natural sciences and medicine, to explore the symptoms of the disease. With this form of arthritis the fluid…

Professor of rheumatology Annette van der Helm focuses her research on the earliest possible detection of inflammatory joint rheumatism to prevent symptoms from becoming chronic.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Four researchers from Leiden University will receive funding from arthritis foundation ReumaNederland over the next five years. This should facilitate long-term research into arthritis.

PhD defence

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

PhD defence

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

PhD defence

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Overkleeft

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PhD defence

Leiden researchers Arjen Doelman, Tom Huizinga and Manfred Wuhrer have been awarded ERC Synergy Grants worth millions of euros for their research on preventing tipping points being reached in ecosystems and helping eradicate rheumatism.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Supervisor: Natalia Ortiz Zacarías

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

From painful joints to intense fatigue: a third of rheumatism patients suffer serious effects from this chronic condition and rely long-term on medication. Leiden psychologists are to receive a subsidy from the Netherlands Arthritis Foundation to investigate whether placebo techniques can help patients…

Early treatment benefits patients who have not fully developed rheumatoid arthritis but are in the preliminary stages of the disease. This is what researchers from the Leiden University Medical Centre (LUMC) have reported in The Lancet. Patients in the pre-arthritis stage who were temporarily prescribed…

More attention should be paid to juvenile idiopathic arthritis. An early diagnosis and robust treatment can prevent irreversible damage. This is what paediatric rheumatologist Rebecca ten Cate said in her inaugural lecture on Friday 22 November 2019.

Leiden chemists have developed a new technique with which they can determine the role of kinases – a group of proteins – in a living cell. This technique makes it easier to find new drug targets for diseases such as cancer and rheumatoid arthritis. The team published the findings in the journal Nature…

Unraveling the immune-suppressive actions of drugs like prednisone.

The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…

Light makes us flourish – in this respect we humans are just like a rose or an azalea. Light can also be used to treat people who are ill. In Leiden, Sylvestre Bonnet and Esther Habers are working – each in their own discipline – on new applications of light in a clinical context.

Since itch and pain can be very burdensome, especially when individuals suffer from (either of) these symptoms chronically, it is important to know the factors by which these sensations are influenced. It becomes more and more clear that psychological factors play an important role in the experience…

A novel in vivo model system for studies on glucocorticoid resistance

From malaria parasites as a vaccine to how top-level bureaucrats reach their decisions: seven researchers from Leiden University have received a Vidi grant from the Dutch Research Council (NWO). This 800,000-euro grant will enable them to develop their own innovative line of research over the next five…

Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…

In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.

An impressive 12 researchers from Leiden University have been awarded an 800,000-euro grant by the Dutch Research Council (NWO). This will enable them to develop their own line of research over the next five years.

Four Leiden researchers have each been awarded a consolidator grant of up to 2 million euros by the European Research Council (ERC). They carry out research on a diverse range of subjects, from gender stereotyping in the field of science to making sugar molecules.

Personalised healthcare could be the answer to insufficient treatment of chronically ill people. Therefore, PhD Junzeng Fu tries to predict the response of a patient to a drug. Strikingly, she combines western medicine with Chinese medicine diagnosis. Promotion Tuesday 21 February.

The Leiden Academic Centre for Drug Research (LACDR) received no less than three awards during the Figon Dutch Medicine Days. Bas Goulooze won the PhD Prize for best PhD candidate, Natalia Ortiz Zacarías and Huub Sijben both received a poster prize. ‘Scientists must be able to communicate their research…

PhD defence

In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Nineteen researchers who have recently been awarded their PhD are to receive a Veni grant of up to 250,000 euros. Science funding agency NWO has awarded a total of 158 Venis in this round; Leiden University's share of the awards is 12 percent.

PhD defence