Overkleeft

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Recently Cambridge University Press published dr. Jan Osters monograph “Media Freedom as a Fundamental Right”.

What opportunities and threats flow from the existence of institutional and normative diversity in the area of fundamental rights for the effective protection of those rights in a pluralist world?

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

This collaborative project aims to explore the history of the concept “barbarism” in Europe from the 18th century to the present, with a particular emphasis on the role of literature and art in the concept’s shifting functions.

Why do we need fundamental science? For a lot of reasons, speakers showed at the Lustrum Symposium ‘Science Matters’. This symposium was held on 18 March 2016 to celebrate the 200th anniversary of the Faculty of Science.

Can the KLM reject an applicant for a job as a pilot or stewardess if they refuse to get vaccinated against Covid-19? Or put more broadly: can the employer of a new employee demand that they are vaccinated? Those questions were at the centre of court proceedings brought on Thursday by the Dutch Airline…

On 22 September, the Social Justice Expertise Center and the Dutch Association on Labor Rights (VVA) brought together eighty (Dutch) labor law lawyers to discuss the relationship between corporate social responsibility (CSR) and fundamental labor rights.

This dissertation provides an up to date description of the Indo European lexical stock of Armenian (ca. 500 entries) with systematic inclusion of unused data that are found in Armenian dialects.

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

Bringing together chemists and physicists to thoroughly investigate how electrochemical processes work on the smallest scale. That is the goal of the new Advanced Nano-electrochemistry Institute of the Netherlands, or ANION for short. The consortium receives a Gravitation funding of 23.6 million euros…

Fundamental rights protect citizens from the government, but they are not absolute. A crisis situation not only gives the government the opportunity to restrict freedoms, it also shows citizens how far it is willing to go in doing so. ‘In the [Dutch] cabinets led by Rutte, there seems to be less and…