2,637 search results for “discovery of the yuan” in the Public website
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Ukraine
This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Screening enormous databases to find a cure for cancer
Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’
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Landscapes of Survival
The Archaeology and Epigraphy of Jordan’s North-Eastern Desert and Beyond
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Palaeolithic fieldschool Barnham UK 2016
This summer seven students from the Faculty of Archaeology crossed the North Sea to assist in the British Museum excavations at East Farm, Barnham, Suffolk, UK – a Middle Pleistocene site. Together with five students from the UK they went through many stages of fieldwork, from scooping the English weather…
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Woolly rhino site reveals ancient British temperature
Scientists, including our faculty colleague Dr. Mike Field, studying an exceptionally well-preserved woolly rhinoceros have revealed details of what Britain's environment was like 42,000 years ago. The beast's remains were discovered in Staffordshire in 2002, buried alongside other preserved organisms…
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Crossing the Intensity Frontier
In the hunt for new particles, physicists look at ever higher energy particle collisions, moving the energy frontier. Some particles however are elusive not due to their high energy, but because they rarely interact. This raises a new barrier: the intensity frontier.
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Video: Leiden archaeologists digging in Oss
Leiden archaeologists have been digging into the municipality of Oss’s past for 50 years now and students have gained their first experience of fieldwork there. What is the result of half a century of research and teaching? Archaeologist Richard Jansen and his students take us to the largest excavation…
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Leiden Academic Centre for Drug Research
Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…
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Quantitative Systems Pharmacology
This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Physicochemical analysis of allosteric binding pockets
Supervisor: Gerard van Westen
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Molecular Physiology
Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Bio-Pharmaceutical Sciences (MSc)
The master’s programme of Bio-Pharmaceutical Sciences at Leiden University examines the research area of bio-pharmaceutical sciences and drug research. It offers seven specialisations ranging from BioTherapeutics to Industrial Pharmacy.
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‘Rembrandt has come home’
Rembrandt Year is concluding with a major exhibition at Museum De Lakenhal. There are still numerous other activities such as lectures, the University Rembrandt Route and the screening of a critical documentary.
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New antibiotic named after Leiden
Increasing resistance and a lack of new antibiotics are a serious problem for public health. Against this background, Gilles van Wezel of the Institute of Biology Leiden is looking for new medicines. Together with former PhD student Changsheng Wu and colleagues he discovered the special antibiotic lugdunomycin,…
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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Doris Jacobs
Dr. Doris M. Jacobs, Lead Scientist at Unilever R&D, Wageningen, The Netherlands.
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Non-linear astrochemical kinetics: theory and applications
This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.
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Koenraad Schalm Group - String Theory and Experiment
Truth is stranger than fiction. In 1997 Juan Maldaceña discovered a remarkable dictionary that translates equation for equation the physics of black holes in string theory into the more conventional physics of quantum mechanics of interacting particles. The remarkable possibility exists that…
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Systems pharmacology-based translational drug pharmacokinetics
High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Strategy
The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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Alexander van Oudenhoven Discoverer of the year 2016
Environmental scientist Alexander van Oudenhoven has been chosen as Discoverer of the year of the Faculty of Science. Vice Rector Magnificus Hester Bijl announced this during the faculty’s New Year’s Reception on 10 January. Biologist Changsheng Wu won the prize for best dissertation of 2016. Computer…
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Better ligands for G Protein-Coupled Receptors
The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.
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Interdisciplinary research and teaching at Leiden University
Many of the challenges of our time are too complex to be resolved within the confines of a single discipline. Leiden University is a broad-based university where an incredible number of research fields converge. That makes us the ideal breeding ground for, and practitioners of, interdisciplinary research…
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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Colloquium night - November 29th
On Tuesday the 29th of November, the SBB Studentboard organized the third SBB Colloquium Night. Max, Guido, Niek, Yiyu and Dennis presented their internships, five topics covering many facets of the Science Based Business courses.
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Award for finding the most extreme stellar object in the Universe
Joseph Callingham from the Leiden Observatory receives the Louise Webster Prize for outstanding post-doctoral research. The prize is awarded by the Astronomical Society of Australia for Callingham’s search for the most extreme object in the Universe.
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Blog Post | Northern Cyprus and the Limitations of Science Diplomacy
Authors: Pierre-Bruno Ruffini and Olga Krasnyak
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‘Ironies of Solidarity’
Economic anthropologist Erik Bähre does research on the morality of insurance. In his latest ethnography ‘Ironies of Solidarity’ Bähre explores how the South African insurance market expanded.
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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Scientists discover the largest stellar black hole in the Milky Way
A European team of astronomers has discovered the largest stellar black hole in the Milky Way. It is more than thirty times as massive as our sun and is located in the constellation of Aquila, about two thousand light-years from Earth. The astronomers stumbled upon the black hole by chance while preparing…
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First measurement of isotopes in atmosphere of exoplanet
An international team of astronomers have become the first in the world to detect isotopes in the atmosphere of an exoplanet. It concerns different forms of carbon in the gaseous giant planet TYC 8998-760-1 b. The research will be published in the scientific journal Nature on Thursday.
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Habsburg family pulled strings to bring raiders of English North Cape expedition to justice
Richard Chancellor, the English Willem Barentsz, discovered the North Cape during the first English expedition to attempt to find a northeast passage. But the ship, the Edward Bonaventure, was ‘robbed by Flemings on its return in 1554.’ Historian Louis Sicking and legal expert Remco van Rhee found the…
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Longevity gene discovered in plants
Harvesting rice from the same field, without planting new rice plants? A discovery may bring this scenario closer. Leiden scientists have discovered a gene that allows annual plants to grow after flowering, instead of dying. Publication on 13 April in Nature Plants.
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Hypoxic Signalling and Tuberculosis
IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.
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Pre-Neanderthalers could handle complex techniques
An international team of researchers including Leiden archaeologists has produced convincing evidence that 300,000 years ago pre-Neanderthal people had a high level of cognitive complexity. New insights into early human capabilities and behaviour.
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Medieval waste matter found in Leiden University Library
Erik Kwakkel, researcher at the Faculty of Humanities, has found an extraordinary manuscript in the University Library’s extensive collection of medieval books. The book in question dates back to the first half of the eleventh century and is made entirely out of waste left over from the production of…
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Professor Ewa Snaar-Jagalska appointed professor in the field of cellular tumor biology
From the 11th of May Ewa Snaar-Jagalska has been appointed Professor in the field of cellular tumor biology within the Faculty of Science at the Institute of Biology Leiden. Her research focuses on the cellular tumor biology and human cancer modeling in zebrafish
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Interview with PhD student: Doris van Bergeijk
Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…
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‘Do something for the broader astronomy community as well’
As Director-General of the ESO for the past ten years, Leiden University astronomer Tim de Zeeuw had ‘the best astronomy job in the world’. Back at the Leiden Observatory, he is focusing on the first 3D map of the Milky Way.
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History is a matter of a longing for rifles and flat screen TVs
History can be found in utensils and in interviews with ordinary citizens. ‘With the reconstruction of everyday life, an anthropological approach works better,’ thinks historian Jan-Bart Gewald. Inaugural lecture on 6 June.
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ERC Synergy Grant to unlock sugar codes for health and a sustainable society
Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…
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Giant rings orbit wrong way around exoplanet
Researchers from Japan and the Netherlands who were previously involved in the discovery of an exoplanet with huge rings have now calculated that the giant rings may persist more than 100,000 years, as long as the rings orbit in the opposite direction to that of the planet around the star. Their findings…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Boest: Bronze Age at its best
Prof. David Fontijn’s Economies of Destruction team was invited by Museum Midtjylland to participate in this year’s excavation in Boest, Jutland (Denmark). The exceptional site of Boest includes burial mounds, an alignment and depositions, consisting of axes, spearheads and rings, dating to the Bronze…