1,937 search results for “cell chemistry” in the Public website
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Measurement of the average mass of proteins adsorbed to a nanoparticle by using a suspended microchannel resonator
SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.
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Astronomer Danna Qasim wins two prizes for dissertation on methane ice
Former Leiden Observatory PhD candidate Danna Qasim has won no less than two prestigious prizes with her thesis, titled 'Dark ice chemistry in interstellar clouds'. Qasim received the IAU PhD Prize from the IAU. The Astrochemistry Subdivision of the American Chemical Society (ACS) honoured her work…
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3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
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Research
An overview of the research at the Cancer Dug Target Discovery group.
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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CCLS Past Events
On this page you can find information about previous CCLS events.
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Metals in Catalysis, Biomimetics & Inorganic Materials
Coordination chemistry is the chemistry of metal atoms
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Vidi Grant for Stefan Semrau: how does bioelectricity shape embryonic development?
Leiden biophysicist Stefan Semrau was granted an NWO Vidi earlier this month. He will use the grant to study the role of electricity in embryonic development and tissue regeneration.
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Therapeutic intervention to enhance atherosclerotic plaque stability-projects
For more information regarding ongoing research projects, please contact Dr. Ilze Bot.
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Bio-Pharmaceutical Sciences and Education (MSc)
The master’s specialisation Bio-Pharmaceutical Sciences and Education at Leiden University combines fundamental chemistry research with an excellent education in becoming a Chemistry teacher.
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Chat with a student
Do you have a question about studying at Leiden University or student life in Leiden? Do you want more information about the Chemistry programme? Chat with a current student for answers to your questions!
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Contact
Division contact information & address
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Cardiovascular Pharmacology
The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Programme structure
In the MSc Chemistry programme you will focus your studies on one of LIC's two main research areas, Chemical Biology or Energy & Sustainability, and one specialisation.
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Blood vessels on a chip make the cause of dementia visible
New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Optimization of quantum algorithms for near-term quantum computers
This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Sylvestre Bonnet
Science
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Erik van Geest
Science
e.p.van.geest@lic.leidenuniv.nl | +31 71 527 2727
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Thomas Hankemeier
Science
hankemeier@lacdr.leidenuniv.nl | +31 71 527 4226
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Therapeutic intervention to enhance atherosclerotic plaque stability
Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…
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The role of auxin in somatic embryogenesis
What is the role of auxin in the initiation and process of somatic embryogenesis?
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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Contact
Contact Biophysical Structural Chemistry
- About this minor
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Admission requirements
To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.
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Immune Activation and Tolerance
The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Development & Disease in Microbial Sciences
Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.
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Development of organ-on-a-chip systems for translational and personalized medicine
We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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Tissue culture
This is a facility where research groups or small companies can apply for space if they need to culture human or animal cells.
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Equipment (Microscopes)
The cell observatory equipment is hosted by several institutes. Each of the institutes maintain their own instruments A detailed list of equipment can be found below per institute
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Physics implications of shape on biological function
Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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LDE Joint Minor Sustainable Chemistry and Biotechnology
Study information
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Biomedical Microscale Analytics
The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Exo-planets, star and planet formation
At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars, which are called exo-planets. They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems.…