Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.

In the summer of 2010, a special archaeological find resurfaced when plans to redevelop the Paardenmarkt, a parking lot in the historic city center of Alkmaar, began.

As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Taras Shevchenko National University of Kyiv.

For the first time, scientists have traced back a high-energy neutrino to its source in space. It was produced by a so-called blazar—a supermassive black hole. Researchers from neutrino detector IceCube report this in Science. ‘This is a milestone for neutrino science,’ says physicist Dorothea Samtleben…

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Biologist Freek Vonk had already appeared in the Time Warp programme, where he was shown milking a snake for its venom, which he needed for his doctoral research. On Friday 18 September, he explained his fascination for snakes to Matthijs van Nieuwkerk in ‘De wereld draait door’, a Dutch news and entertainment…

Universiteit Leiden in cooperation with Naturalis, the University of Amsterdam (UvA) and University Wageningen is foundig a center for biodiversity. They will receive 30 million euros from The Ministry of Education, Culture and Science (OCW).

How can zebrafish research help to understand and fight human cancer?

Supervisor: Andrea Martella

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

For her bachelor’s thesis, Molecular Science and Technology student Madouc Bergers synthesized her own molecule that can inhibit the breakdown of sugars. Although most students do not even manage to make one building block, Madouc made three. Partly because of this, she has been nominated for the Science…

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…

Key publications of the Predictive Pharmacology group.

Where exactly on the surface of a catalyst do the chemical reactions occur? Until now, it has always been a challenge to identify the exact locations of these ‘active sites’. In a new article in Nature, Leiden chemists helped their international colleagues reveal new insights into this issue. Their…

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

Many students receive their first job offer during or right after their Business Studies internship. After graduating you can also aim for a career in Bio-Pharmaceutical research.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

Supervisor: Gerard van Westen

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.

Promotor: B. van de Water

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years

It was her original Salterio from 1725, built by Michele Barbi, which Franziska Fleischanderl could coincidentally acquire in 2014 that ignited her passion for this special string instrument. Before, she was focussed on contemporary music with modern Hackbrett.

Drug use during pregnancy seems like a choice without any consequences. However, the Dutch Public Prosecution Service (OM) has decided to prosecute a mother for using alcohol and drugs during her pregnancy. Mariëlle Bruning, Professor of Child Law, tells current affairs programme ‘Nieuwsuur’ that she…

On Friday evening 17 September, Leiden astronomer Joe Callingham can be seen in a new series on Discovery channel. Killers of the Cosmos is about different deadly dangers lurking in the depths of space. Asteroids, cosmic debris, electromagnetic weapons… The show takes a film-noir approach to these threats,…

In a recent article published on PLOS, Drs. Briana Pobiner and Ryan McRae of the Smithsonian Institution National Museum of Natural History discuss the top 13 discoveries in human evolution in 2023.

Improving lives and fostering integration with Big Data

The IBL represents the core of modern biological research at Leiden and we interact closely with the other life science Partner Institutes in the faculty:

Supervisor: Xue Yang

The Lorentz Center is a melting pot that is visited by researchers from around the world. ‘Miracles happen’ during the five-day interactive workshops at the Center. And there is an extra reason to celebrate the center’s 25th anniversary. On 28 April, the Dutch Research Council (NWO) and Leiden University…

Gerard van Westen and his group, together with pharmaceutical company Galapagos, start on developing software that invents new effective molecules. They will receive an NWO LIFT grant of 280,000 euros, of which 63,000 euros will come from Galapagos. The company will also bring its expertise in biology,…

In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…

Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

On an excavation site in Oegstgeest Leiden University archaeologists discovered a very rare silver bowl from the first half of the seventh century. The bowl is decorated with gold-plated representations of animals and plants and inlaid with semi-precious stones. The discovery suggests the existence…