Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

The two-years MSc programme spans the entire spectrum of Analytical BioSciences, Biopharmaceutics, Drug Delivery Technology, Medicinal Chemistry, Pharmacology and Toxicology.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Science, Leiden Institute of Physics (LION)

Science, Institute of Biology Leiden (IBL)

Leiden Journal of Pottery Studies 23, 2007

Leiden Journal of Pottery Studies 22, 2006

Leiden Journal of Pottery Studies 21, 2005

We are happy to announce the 4th annual LION Image Award!

We are happy to announce the 3rd annual LION Image Award!

Making the most vibration-free, cryogenic scanning tunneling microscope in the world. A bold mission, but one that PhD candidate Irene Battisti successfully executed together with the Fine Mechanical Department. The new microscope might shed light on how unconventional superconductivity works. PhD Defence…

Multidrug-resistant pathogens and worldwide pandemics are increasing, making infectious diseases more prevalent. To develop new treatments, deeper knowledge of the interaction between bacteria and human cells is required. Ariane Briegel recently became a Medical Delta professor and studies such path…

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

A new executive board has been installed at NeCEN, a state-of-the art facility that offers the most advanced cryo-electron microscopes worldwide. The new board members are full of excitement: what are their ideas for the future of the facility?

The Phase 3 clinical trial results of the promising Covid-19 vaccine of Johnson & Johnson are expected this month. The Dutch electron microscopy facility NeCEN helped develop the company’s vaccine, and they have now published their scientific findings in Nature Communications.

A passion for video games, visuals and science: it almost seems impossible to bring all of this together. Yet, scientific animator Vera Williams found that dream combination at NeCEN's microscopy lab. 'An image or animation can help clarify the content of complex research.'

Tussen de sterren is niet alleen leegte. Er zweven ook stoffen als methanol en koolstofdioxide. Chemische theorieën kunnen nog niet verklaren hoe die zijn ontstaan onder omstandigheden die dat juist onmogelijk zouden moeten maken. Fedor Goumans gaat met een Veni-beurs proberen die vraag te beantwoor…

Stacked layers of graphene can act like a mirror for beams of electrons. Physicists Daniël Geelen and colleagues discovered this using a new type of electron microscope. In an article in Physical Review Letters, they describe their results, which could lead to the development of optics for electron…

Physicist Milan Allan will build an instrument that will bring superconductivity research further. He has been awarded an ERC Consolidator Grant of 2 million euros over the next five years. With his PairNoise programme he aims to detect paired electrons as they occur just above the temperature at which…

The new project INFLANET will train young scientists in Europe to become experts in inflammation research. Professor Annemarie Meijer from the Institute of Biology Leiden coordinates the training.

Five projects with researchers from Leiden University have received a grant from the Dutch Research Council (NWO) to build or upgrade existing research facilities.

Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.

Last Monday April 18, Bram Koster (professor at the Institute of Biology Leiden (IBL), professor at the Leiden University Medical Center (LUMC)) and Ariane Briegel (professor at the IBL) gave a presentation to the mayor of Leiden, Henri Lenferink. The presentation took place at NeCEN, the open access…

The winner of the Paul & Tatiana Ehrenfest physics thesis prize 2020 is Koen Bastiaans. He carried out his PhD research in the group of Milan Allan and defended his thesis in December 2019 cum laude at Leiden University.

Cell-based medicinal products (CBMPs) belong to an innovative and heterogeneous group of medicines called advanced therapy medicinal products (ATMPs). The limited analytical toolbox for CBMP characterization and release testing is one of the reasons why CBMP development is so challenging.

Mapping of bacterial genomes to combat infectious diseases

In 2021 we will start with a weekly lunch time seminar series, online on Mondays from 12 noon onwards.

On Monday 21 September Annemarie Meijer, Professor of Immunobiology, presented her inaugural lecture on immunobiology and infectious disease.

The European FET-Horizon2020 LMCat project of Dr. Irene Groot has released a promotional video showing the role graphene could play in our daily lives, how LMCat's production technique works, and how the consortium is capable of taking graphene production to the next level.

On April 20, sixty participants will take part in LION’s triannual meeting for high school physics teachers, to deepen their knowledge of physics and astronomy and to explore new teaching methods. This edition marks a special occasion, as it is the last meeting organized by Bert van der Hoorn, who will…

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

Current research at the Skin Barrier and Vaccination group.

The doors of the new Gorlaeus Building are officially open! With an additional lab wing, new lecture halls and offices, a library, a brasserie, and spaces for student associations, the building offers a vibrant and inspiring environment for research, study, and social interaction. Explore on your…

The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.

Relevant publications of the CIGR participants.

Organ-on-chip technology is used in drug research and customized treatments for patients. Research Institutes and industry join forces within the Institute for human Organ and Disease Model Technologies (hDMT) that was officially launched on May 18. Combining facilities, people and expertise will allow…

The Dutch Research Council (NWO) has granted four grants to Leiden humanities scholars. They get to spend this money on research on a topic of their choice, without thematic preconditions.

Prof. Dr. Ir. Marin van Heel, Emeritus Professor at the Institute of Biology Leiden (NeCEN), is one of the winners of the “Wiley Prize in Biomedical Sciences 2017”. This annual award is presented to recognize contributions that have opened new fields of research or have advanced concepts in a particular…

Leiden Physicists have developed a new technique to visualize electrical conductance in sheet-like nano materials. It shows great promise for devices based on a new family of materials—the ‘Van der Waals materials’. The physicists, who won the 2015 Dutch Vacuum Society prize for their work, present…

The European Research Council (ERC) has awarded chemist Dr Alexander Kros a Starting Independent Researcher Grant of 1.4 million euro. He will be using the grant to study how molecules penetrate the natural barrier of a cell membrane. If his research is successful, it will in time bring about a revolution…

Eleven Leiden researchers have been awarded an 800,000 euro Vidi grant by the Dutch Research Council (NWO). This will enable them to develop their own innovative line of research and start their own research group.

As of 1 June, Leiden University has appointed Sense Jan van der Molen as Professor Physics of Condensed matter. He investigates the unique electronic properties that arise when atomic thin layers are stacked on top of each other into new materials.

Mysterious protein fibers show up in the brain cells of people suffering from Alzheimer’s' disease and other neurodegenerative disorders. Leiden physicist Louise Jawerth has been awarded a Vidi grant to find out how these fibers form in the first place.

The image of the Leiden microboat traveled all over the world, from the BBC up to Arab shipping blogs. But Daniela Kraft's research group has quite a few more different 3D printed microswimmers up their sleeves. Kraft receives a Vidi research grant for research into these variously shaped active par…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

He presented his PhD research entitled “Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling”. During his presentation, Rob highlighted the advancements he made in using zebrafish as model in system pharmacolog…

Why do some bacteria lose their protective cell wall under the influence of stress? Microbiologist Dennis Claessen of the Institute of Biology Leiden receives a Vici grant of 1.5 million euros from the Dutch Research Council (NWO) to investigate this paradoxical feature.

Mazène Hochane and Xueying Fan have won the fourth annual LION Image Award. They created a detailed colour image of a human kidney in development.

Leiden University has appointed John van Noort as Professor in Biophysics. He studies the way in which our DNA is folded and read out.