IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

Leiden researchers Arko Ghosh and Enea Ceolini analysed the usage data of hundreds of mobile phones and discovered that our body has rhythms ranging between 7 and 52 days. These cycles influence how we behave. Their research resulted in an article in npj Digital Medicine journal, a Nature Portfolio…

Jan de Vetten brengt zijn promotieonderzoek ook uit in boekvorm. ‘In de ban van goed en fout’ beschrijft voor het eerst - op basis van archiefonderzoek en interviews - op samenhangende wijze de bestrijding van de CP en CD, en ook de reactie daarop van die partijen. Waarom werden ze zo fel werden bestreden?…

When does it rain when air is oversaturated with moisture? How does an infection spread among the population? The problems that mathematician Professor Frank den Hollander tries to solve come from physics, chemistry and biology.

Emerging from the first wave relatively unscarred to an increase in infections. This research analyses the response from the Bulgarian government to Covid-19.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Linda Stuckrath Gottschalk defended her thesis on 6 April 2016.

Key publications of the Biologics Formulation group

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The rise and fall of Dutch Brazil (1624-1654) was a major news story in early modern Europe, and marked the emergence of a

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

Ilina Georgieva published an article in the journal Contemporary Security Policy on the norm-setting role of intelligence agencies.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon

The MicroSOS project is designed to bring together academic and industrial partners with different expertises to address challenges that agriculture is facing due to climate change and invests in the development of microbiome-based solutions towards more sustainable agricultural practices.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

A job thanks to COVID—something not many people can claim. But PhD candidate Vera Arntzen can. Over the past four years, she has mapped two crucial characteristics of SARS-CoV-2 infections. Thanks to her research, experts can now make well-informed decisions on matters like quarantine duration, which…

In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.

Researchers from Leiden University Medical Center (LUMC) have discovered how malaria parasites escape the immune system of mosquitoes. The so-called QC enzyme changes proteins on the outside of the malaria parasite such that the immune cells are unable to recognise the parasite. As a result, the parasite…

Career and apply for jobs

PhD defence

PhD defence

PhD defence

This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.

What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?

Tijmen Baarda defended his PhD thesis on 8 January 2020

This book examines the history of The Netherlands in a way that connects global processes to local developments.

Source: Eur J Med Chem (2015)

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Inspiring and relaxed – these are qualities that describe the Netherlands perfectly. At the same time, there is much more to say about the country. For instance, according to the 2018 UN Human Development Index, the Netherlands is ranked tenth among the best countries to live in.

On 18 April, Alexandre Tavadian defended the thesis 'The International Civil Service: Redefining Its Independence'. The doctoral research was supervised by Niels Blokker and Brian McGarry.

Promotores: H.A. Udo De Haes, P.M. Brakefield

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.